Výsledky vyhledávání - "Rocío Cejudo-Marín"

Akademický článek

Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents

Autor: Alberto Pla-López, Raquel Castillo, Rocío Cejudo-Marín, Olaya García-Pedrero, Mariam Bakir-Laso, Eva Falomir, Miguel Carda

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 13, p 7049 (2022)

Twenty-six triazole-based derivatives were designed for targeting both PD-L1 (programmed death receptor ligand 1) and VEGFR-2 (vascular endothelial growth factor receptor 2). These compounds were synthetized and biologically evaluated as multitarget

Externí odkaz: https://doaj.org/article/b1b67c01a80b41a5aaa6c96833773a71

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Monitoring the evolution of SARS-CoV-2 on a Spanish university campus through wastewater analysis: A pilot project for the reopening strategy

Autor: Rosa de Llanos, Rocío Cejudo-Marín, Manuela Barneo, Alba Pérez-Cataluña, María Barberá-Riera, Marisa Rebagliato, Juan Bellido-Blasco, Gloria Sánchez, Félix Hernández, Lubertus Bijlsma

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Wastewater surveillance is a fast and cost-effective tool that enables tracing of both symptomatic and asymptomatic transmission of SARS-CoV-2. In this paper, a pilot program carried out at the University Jaume I for monitoring the trends of the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef433f76215c067801b61eed920fa060
http://hdl.handle.net/10261/280566

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Caspase-3 Cleavage of DUSP6/MKP3 at the Interdomain Region Generates Active MKP3 Fragments That Regulate ERK1/2 Subcellular Localization and Function

Autor: Céline Tárrega, Caroline E. Nunes-Xavier, Rafael Pulido, Rocío Cejudo-Marín

Publikováno v: JOURNAL OF MOLECULAR BIOLOGY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

MAPK (MAP kinase) phosphatase 3 (DUSP6/MKP3) is a cytosolic MKP (MAPK phosphatase) that regulates negatively ERK1/2 downstream to growth factor or apoptotic signaling. Transcription of DUSP6 gene is activated through the ERK1/2 pathway, which constit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1576a55aa2d1236ee84c26918924d708
https://doi.org/10.1016/j.jmb.2012.04.004

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ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1

Autor: Rafael Pulido, Wiljan Hendriks, Rocío Cejudo-Marín, Carmen Blanco-Aparicio, Jan Schepens, Lydia Tabernero, Lieke C. J. van den Berk, Pablo Rios, Céline Tárrega

Publikováno v: Journal of Biological Chemistry, 280, 37885-94
Journal of Biological Chemistry, 280, 45, pp. 37885-94

Contains fulltext : 48764.pdf (Publisher’s version ) (Open Access) The two regulatory residues that control the enzymatic activity of the mitogen-activated protein (MAP) kinase ERK2 are phosphorylated by the unique MAP kinase kinases MEK1/2 and dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3791f74110fef88dfcff539fa001cc8
https://doi.org/10.1074/jbc.M504366200

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Inhibition of VEGF expression in cancer cells and endothelial cell differentiation by synthetic stilbene derivatives

Autor: Miguel Carda, Eva Falomir, Juan Murga, Rocío Cejudo-Marín, J. Alberto Marco, Rosa Martí-Centelles

Publikováno v: Bioorganicmedicinal chemistry. 21(11)

We here report the synthesis of several stilbene derivatives. They show a measurable inhibitory effect on angiogenesis, some of them to a higher degree than resveratrol. Test methods included cell proliferation and tube formation assays using bovine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be42a4f2215ce74d203624fc2c786b0d
https://pubmed.ncbi.nlm.nih.gov/23623255

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Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways

Autor: Andres Alonso, Rafael Pulido, Stephen M. Keyse, Antonio García Trinidad, Laurent Delavaine, Mark P. Didmon, Christopher J. Staples, Robin J. Dickinson, Rocío Cejudo-Marín, Graeme Stewart

Publikováno v: JOURNAL OF BIOLOGICAL CHEMISTRY
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
The Journal of Biological Chemistry
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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Digital.CSIC. Repositorio Institucional del CSIC

MAP kinase phosphatase 4 (DUSP9/MKP-4) plays an essential role during placental development and is one of a subfamily of three closely related cytoplasmic dual-specificity MAPK phosphatases, which includes the ERK-specific enzymes DUSP6/MKP-3 and DUS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66c2ca6deb2c7df65a81472bc0320c8
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2453

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Studying the regulation of MAP kinase by MAP kinase phosphatases in vitro and in cell systems

Autor: Rafael Pulido, Rocío Cejudo-Marín, Caroline E. Nunes-Xavier, Jorge Martín-Pérez, Céline Tárrega

Publikováno v: MAP Kinase Signaling Protocols ISBN: 9781607617945
Digital.CSIC. Repositorio Institucional del CSIC
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Signaling through MAPK pathways involves a network of activating kinases and inactivating phosphatases. While single MAPK kinases account for specific activation of the distinct MAPKs, inactivation of MAPKs by phosphatases involves a wider spectrum o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3030ad5ca11fa94eb63729240d6a15f9
http://hdl.handle.net/10261/77929

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Differential Up-regulation of MAP Kinase Phosphatases MKP3/DUSP6 and DUSP5 by Ets2 and c-Jun Converge in the Control of the Growth Arrest Versus Proliferation Response of MCF-7 Breast Cancer Cells to Phorbol Ester

Autor: Jeroen Frijhoff, Åsa Sandin, Céline Tárrega, Rafael Pulido, Arne Östman, Rocío Cejudo-Marín, Caroline E. Nunes-Xavier

Publikováno v: JOURNAL OF BIOLOGICAL CHEMISTRY
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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Different levels of regulation account for the inactivation of MAP kinases by MAPK phosphatases (MKPs), in a cell type- and stimuli-dependent manner. MCF-7 human breast carcinoma cells treated with the phorbol 12-myristate 13-acetate (PMA) suffer gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8419a64cf8d1c1d8c2b55feab138ad87
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2685

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Dual-specificity MAP kinase phosphatases as targets of cancer treatment

Autor: Pablo Rios, Céline Tárrega, Rocío Cejudo-Marín, Rafael Pulido, Carlos Romá-Mateo, Caroline E. Nunes-Xavier, Lydia Tabernero

Publikováno v: Scopus-Elsevier
Anti-Cancer Agents in Medicinal Chemistry
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
University of Manchester-PURE
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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The protein tyrosine phosphatase family (PTP) contains a group of dual-specificity phosphatases (DUSPs) that regulate the activivity of MAP kinases (MAPKs), which are key effectors in the control of cell growth and survival in physiological and patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc083c38c972deb467ce723c959f5d7d
http://www.scopus.com/inward/record.url?eid=2-s2.0-79953018680&partnerID=MN8TOARS

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