Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rocío Alfaro-Ruíz"'
Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease
Autor:
Ana Toledano-Zaragoza, Violeta Enriquez-Zarralanga, Sara Naya-Forcano, Víctor Briz, Rocío Alfaro-Ruíz, Miguel Parra-Martínez, Daniel N. Mitroi, Rafael Luján, José A. Esteban, María Dolores Ledesma
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-13 (2024)
Abstract Niemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to psychiatric alterations. Using an NPC mouse model (Npc1nmf164) we show aberrant
Externí odkaz:
https://doaj.org/article/a29dff6528f64981ad437746890a57a7
Autor:
Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruíz, Makoto Itakura, Ana Esther Moreno-Martínez, Luis de la Ossa, Elek Molnár, Yugo Fukazawa, Rafael Luján
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Synapse loss occurs early in Alzheimer’s disease (AD) patients and animal models. Alterations at synaptic level are a major morphological correlate of the memory deficits and related symptoms of AD. Given the predominant roles of synaptic AMPA rece
Externí odkaz:
https://doaj.org/article/88985e5042a54c9aba45bb1318adb97c
Autor:
Rocío Alfaro-Ruíz, Carolina Aguado, Alejandro Martín-Belmonte, Ana Esther Moreno-Martínez, Rafael Luján
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6403 (2020)
The K+ channel interacting proteins (KChIPs) are a family of cytosolic proteins that interact with Kv4 channels, leading to higher current density, modulation of channel inactivation and faster recovery from inactivation. Using immunohistochemical te
Externí odkaz:
https://doaj.org/article/eecba4dbc68448f4a72728a3fad929ea
Autor:
Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruíz, Ana Esther Moreno-Martínez, Luis de la Ossa, José Martínez-Hernández, Alain Buisson, Ryuichi Shigemoto, Yugo Fukazawa, Rafael Luján
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2459 (2020)
Metabotropic γ-aminobutyric acid (GABAB) receptors contribute to the control of network activity and information processing in hippocampal circuits by regulating neuronal excitability and synaptic transmission. The dysfunction in the dentate gyrus (
Externí odkaz:
https://doaj.org/article/6aede5481e954390a09c4e40bdee7df7
Autor:
Rocío Alfaro-Ruíz, Carolina Aguado, Alejandro Martín-Belmonte, Ana Esther Moreno-Martínez, Rafael Luján
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 2, p 246 (2019)
The Kv4 family of voltage-gated K+ channels underlie the fast transient (A-type) outward K+ current. Although A-type currents are critical to determine somato-dendritic integration in central neurons, relatively little is known about the precise subc
Externí odkaz:
https://doaj.org/article/2644fb86aecf491da63e9a68ea1f4eec
Autor:
Rocio Alfaro-Ruiz, Alejandro Martín-Belmonte, Carolina Aguado, Ana Esther Moreno-Martínez, Yugo Fukazawa, Rafael Luján
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-16 (2024)
Abstract Synaptic dysfunction is an early feature in Alzheimer’s disease (AD) pathogenesis and a major morphological correlate of memory deficits. Given the main synaptic location of N-methyl-D-aspartate receptors (NMDARs), their dysregulation has
Externí odkaz:
https://doaj.org/article/dc5e597fa919457eaabb9d675def2f90
Autor:
Carolina Aguado, Sara Badesso, José Martínez-Hernández, Alejandro Martín-Belmonte, Rocío Alfaro-Ruiz, Miriam Fernández, Ana Esther Moreno-Martínez, Mar Cuadrado-Tejedor, Ana García-Osta, Rafael Luján
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 9, Pp 2068-2074 (2024)
[INLINE:1] Plaques of amyloid-β (Aβ) and neurofibrillary tangles are the main pathological characteristics of Alzheimer's disease (AD). However, some older adult people with AD pathological hallmarks can retain cognitive function. Unraveling the fa
Externí odkaz:
https://doaj.org/article/cb89811a5f93417db9ab17bae6510143
Autor:
Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Luis de la Ossa, Ester Aso, Laura Gómez-Acero, Ryuichi Shigemoto, Yugo Fukazawa, Francisco Ciruela, Rafael Luján
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Alzheimer’s disease (AD) is characterized by a reorganization of brain activity determining network hyperexcitability and loss of synaptic plasticity. Precisely, a dysfunction in metabotropic GABAB receptor signalling through G protein-gat
Externí odkaz:
https://doaj.org/article/ad403bc9036e48249c0c8a940b3435b4
Autor:
Syong H. Nam-Cha, Elena Domínguez-Jurado, Selena L. Tinoco-Valencia, Ramón Pérez-Tanoira, Noelia Morata-Moreno, Rocío Alfaro-Ruiza, Agustín Lara-Sánchez, Jaime Esteban, Rafael Luján, Carlos Alonso-Moreno, Pedro Seguí, Alberto Ocaña, Ángel López Gónzalez, John J. Aguilera-Correa, Francisco C. Pérez-Martínez, Milagros Molina Alarcón
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Staphylococcus aureus is one of the species with the greatest clinical importance and greatest impact on public health. In fact, methicillin-resistant S. aureus (MRSA) is considered a pandemic pathogen, being essential to develop effective medicines
Externí odkaz:
https://doaj.org/article/d4a2875e0d204087b3f8db161c84d89f
Autor:
Rafael Luján, Angel Merchán-Pérez, Joaquim Soriano, Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Javier DeFelipe
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2021)
Small-conductance calcium-activated potassium (SK) channels are crucial for learning and memory. However, many aspects of their spatial organization in neurons are still unknown. In this study, we have taken a novel approach to answering these questi
Externí odkaz:
https://doaj.org/article/7945b7e7126e487da50eb878cedfe96b