Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Robyn S Klein"'
Autor:
Priya Pal, Amanda E Balaban, Michael S Diamond, Photini Sinnis, Robyn S Klein, Daniel E Goldberg
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177142 (2017)
A devastating complication of Plasmodium falciparum infection is cerebral malaria, in which vascular leakage and cerebral swelling lead to coma and often death. P. falciparum produces a protein called histidine-rich protein II (HRPII) that accumulate
Externí odkaz:
https://doaj.org/article/ff2d3ea5855f4630979120aeed0c8582
Autor:
Brian P Daniels, Robyn S Klein
Publikováno v:
PLoS Pathogens, Vol 11, Iss 9, p e1005096 (2015)
Externí odkaz:
https://doaj.org/article/ca14fddb13394b65bfab62edd229b880
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
In the adult central nervous system (CNS), chemokines and their receptors are involved in developmental, physiological and pathological processes. Although most lines of investigation focus on their ability to induce the migration of cells, recent st
Externí odkaz:
https://doaj.org/article/41703e64da064824ac9cae92b266af00
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e64647 (2014)
Globoid-cell Leukodystrophy (GLD; Krabbe's disease) is a rapidly progressing inherited demyelinating disease caused by a deficiency of the lysosomal enzyme Galactosylceramidase (GALC). Deficiency of GALC leads to altered catabolism of galactosylceram
Externí odkaz:
https://doaj.org/article/b6d54ba5f817454e85535cf206aefb9f
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96442 (2014)
Lymphocytic choriomeningitis virus (LCMV) can be transmitted through congenital infection, leading to persistent infection of numerous organ systems including the central nervous system (CNS). Adult mice persistently infected with LCMV (LCMV-cgPi mic
Externí odkaz:
https://doaj.org/article/6ecd374666fe4199bd61f78e3a736b3f
Autor:
Matthew D. Cain, N. Rubin Klein, Xiaoping Jiang, Hamid Salimi, Qingping Wu, Mark J. Miller, William B. Klimstra, Robyn S. Klein
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Venezuelan Equine Encephalitis virus (VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that originate in the nasal cavity after intranasal exposure. While it is known that VEEV has evolved se
Externí odkaz:
https://doaj.org/article/05a07a3010704277b2efd1dcf91ec07d
Autor:
Kristy J Szretter, Brian P Daniels, Hyelim Cho, Maria D Gainey, Wayne M Yokoyama, Michael Gale, Herbert W Virgin, Robyn S Klein, Ganes C Sen, Michael S Diamond
Publikováno v:
PLoS Pathogens, Vol 8, Iss 5, p e1002698 (2012)
Prior studies have shown that 2'-O methyltransferase activity of flaviviruses, coronaviruses, and poxviruses promotes viral evasion of Ifit1, an interferon-stimulated innate immune effector protein. Viruses lacking 2'-O methyltransferase activity exh
Externí odkaz:
https://doaj.org/article/791cda7ce65d4052bb76e27b424652f6
Autor:
Artem Arutyunov, Violeta Durán-Laforet, Shenjian Ai, Loris Ferrari, Robert Murphy, Dorothy P. Schafer, Robyn S. Klein
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 808 (2024)
Microglia, the resident macrophages of the central nervous system, exhibit altered gene expression in response to various neurological conditions. This study investigates the relationship between West Nile Virus infection and microglial senescence, f
Externí odkaz:
https://doaj.org/article/f3f5f49756aa49bab2010450111a43fe
Autor:
Natasha M. Kafai, Hana Janova, Matthew D. Cain, Yael Alippe, Stefanie Muraro, Alan Sariol, Michelle Elam-Noll, Robyn S. Klein, Michael S. Diamond
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112946- (2023)
Summary: Venezuelan equine encephalitis virus (VEEV) is an encephalitic alphavirus responsible for epidemics of neurological disease across the Americas. Low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3) is a recently reported en
Externí odkaz:
https://doaj.org/article/128a62baae2949b18c6c14e4e103cc19
Autor:
Heather E. Whitson, Carol Colton, Joseph El Khoury, David Gate, Alison Goate, Michael T. Heneka, Rima Kaddurah-Daouk, Robyn S. Klein, Mari L. Shinohara, Sangram Sisodia, Serena S. Spudich, Beth Stevens, Rudolph Tanzi, Jenny P. Ting, Gwenn Garden, Alison Aiello, Ornit Chiba-Falek, Joseph Heitman, Kim G. Johnson, Micah Luftig, Ashley Moseman, Jonathan Rawls, Ronald Swanstrom, Niccolo Terrando
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 22, Iss , Pp 100462- (2022)
Neuroinflammation has been recognized as a component of Alzheimer's Disease (AD) pathology since the original descriptions by Alois Alzheimer and a role for infections in AD pathogenesis has long been hypothesized. More recently, this hypothesis has
Externí odkaz:
https://doaj.org/article/122264f3ba1c453b82785df1ba723c52