Maraviroc prevents hcc development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model

Autor: Joaquín Fernández-Irigoyen, Sarah B. McSpadden, Luke A. Diepeveen, Janina E.E. Tirnitz-Parker, Alfredo Martínez, Bernard A. Callus, Weihao Zhao, Enrique Santamaría, Caryn L. Elsegood, Hyerin Park, Ken H. Woo, Andy Chevigné, Adam M. Passman, Laura Ochoa-Callejero, Roslyn London, George C.T. Yeoh, José Ramón Blanco, Martyna Szpakowska, Robyn P. Strauss, Laura Medina-Ruiz, Megan Finch-Edmondson, Rodrigo Carlessi, Murray V. Baker, Neil Andrewartha

Publikováno v: RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
Cancers, Vol 13, Iss 4935, p 4935 (2021)
Cancers
Volume 13
Issue 19
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra

Maraviroc (MVC), a CCR5 antagonist, reduces liver fibrosis, injury and tumour burden in mice fed a hepatocarcinogenic diet, suggesting it has potential as a cancer therapeutic. We investigated the effect of MVC on liver progenitor cells (LPCs) and ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba21101ccb47614a9abb1a1143a5339
https://hdl.handle.net/2454/42707

Loss of ARF/INK4A Promotes Liver Progenitor Cell Transformation Toward Tumorigenicity Supporting Their Role in Hepatocarcinogenesis

Autor: Joanne H. van Vuuren, Robyn P. Strauss, Bernard A. Callus, Megan Finch-Edmondson, Katherine M. Audsley, Adam M. Passman, George C.T. Yeoh

Publikováno v: Gene Expr

Liver progenitor cells (LPCs) contribute to liver regeneration during chronic damage and are implicated as cells of origin for liver cancers including hepatocellular carcinoma (HCC). The CDKN2A locus, which encodes the tumor suppressors alternate rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1799c929cdd02db15481fbf8b52740
https://europepmc.org/articles/PMC7284103/

Epigenetic Modulators Enhance Constitutive and Liver-Specific Reporter Expression in Murine Liver Progenitor Cell Lines

Autor: Sarah B. McSpadden, George C.T. Yeoh, Michel Elyse Watson, Robyn P. Strauss, Bernard A. Callus, Luke A. Diepeveen

Publikováno v: Tissue Engineering Part C: Methods. 21:1080-1087

Stem cells expressing reporter constructs are extremely useful for their tracking in vivo or for determining cell lineage fate in vivo and in vitro. We generated liver progenitor cell (LPC) lines from actin-EGFP and TAT-GRE-lacZ mice. LPCs from the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e648943d0e58d171b556b6f758f2c959
https://doi.org/10.1089/ten.tec.2015.0131

A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice

Autor: Roslyn London, Megan Finch-Edmondson, Adam M. Passman, Ken H. Woo, Sarah B. McSpadden, Luke A. Diepeveen, George C.T. Yeoh, Robyn P. Strauss, Bernard A. Callus

Publikováno v: Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 8, Iss 12, Pp 1635-1641 (2015)

The choline-deficient, ethionine-supplemented (CDE) dietary model induces chronic liver damage, and stimulates liver progenitor cell (LPC)-mediated repair. Long-term CDE administration leads to hepatocellular carcinoma in rodents and lineage-tracing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60dff429c0aa1c18df3a609a9a98a48
https://pubmed.ncbi.nlm.nih.gov/26496771

Sub-cellular localisation studies may spuriously detect the Yes-associated protein, YAP, in nucleoli leading to potentially invalid conclusions of its function.

Autor: Megan L Finch, Adam M Passman, Robyn P Strauss, George C Yeoh, Bernard A Callus

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0114813 (2015)

The Yes-associated protein (YAP) is a potent transcriptional co-activator that functions as a nuclear effector of the Hippo signaling pathway. YAP is oncogenic and its activity is linked to its cellular abundance and nuclear localisation. Activation

Externí odkaz: https://doaj.org/article/a18ed646f0b24c7bb5871055161104fd