Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Robyn M, Slattery"'
Publikováno v:
Frontiers in Immunology
Many pathogens, including the malaria parasite Plasmodium falciparum, display high levels of polymorphism within T-cell epitope regions of proteins associated with protective immunity. The T-cell epitope variants are often non-cross-reactive. Herein,
Autor:
Kate L, Graham, Balasubramanian, Krishnamurthy, Stacey, Fynch, Rochelle, Ayala-Perez, Robyn M, Slattery, Pere, Santamaria, Helen E, Thomas, Thomas W H, Kay
Publikováno v:
European journal of immunology. 42(7)
Infiltration of pancreatic islets by immune cells, termed insulitis, increases progressively once it begins and leads to clinical type 1 diabetes. But even after diagnosis some islets remain unaffected and infiltration is patchy rather than uniform.
Publikováno v:
Immunological Reviews. 118:21-35
Self-tolerance is generally induced by intrathymic clonal deletion of T cells with reactivity directed to antigens synthesized within the thymus (Kappler et al. 1987, Kisielow et al. 1988). It may also be induced in peripheral T cells when these enco
The association of major histocompatibility complex genes with autoimmune diseases is firmly established, but the mechanisms by which these genes confer resistance or susceptibility remain controversial. The controversy extends to the nonobese diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01524fa601ab9ec268e64b79a3201340
https://europepmc.org/articles/PMC47867/
https://europepmc.org/articles/PMC47867/
Autor:
Thomas E. Mandel, Jacques F. A. P. Miller, Brett Charlton, Janette Allison, Robyn M. Slattery, Lars Kjer-Nielsen
Publikováno v:
Nature. 345(6277)
The non-obese diabetic (NOD) mouse develops insulin-dependent diabetes mellitus (IDDM) with mononuclear cell infiltration of the islets of Langerhans and selective destruction of the insulin-producing beta-cells, as in humans. Most infiltrating cells