Výsledky vyhledávání - "Robyn Lukeis"

CD30 and ALK combination therapy has high therapeutic potency in RANBP2-ALK-rearranged epithelioid inflammatory myofibroblastic sarcoma

Autor: Toby Trahair, Carol Wadham, Zara Ali, Glenn M. Marshall, Emily Mould, Lisa T. Morgan, Mitali Fadia, Jinhan Xie, Jamie I. Fletcher, Lei Zhai, Ashleigh M. Fordham, Andrew J. Gifford, Karen L. MacKenzie, Robyn Lukeis, Hassina Massudi

Publikováno v: British Journal of Cancer

BackgroundEpithelioid inflammatory myofibroblastic sarcoma (eIMS) is characterised by perinuclear ALK localisation, CD30 expression and early relapse despite crizotinib treatment. We aimed to identify therapies to prevent and/or treat ALK inhibitor r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5753200f48d082550ba357982e322763
https://doi.org/10.1038/s41416-020-0996-2

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Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase

Autor: Robyn Lukeis, Duo Wang, Robert Max Conway, Sharron Liang, Svetlana Cherepanoff, Li-Anne Lim, Michael Giblin, David Van Ly, Luke B. Hesson

Publikováno v: Ocul Oncol Pathol

Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad387ee307b8f0f8aed8a87116d7f60
https://europepmc.org/articles/PMC7772867/

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Rare MYC-amplified Neuroblastoma With Large Cell Histology

Autor: Hiroyuki Shimada, Robyn Lukeis, Junming Fang, Shahab Asgharzadeh, Araz Marachelian, Ryosuke Matsuno, Tohru Sugimoto, Toby Trahair, John M. Maris, Naohiko Ikegaki, Mikako Warren, Andrew J. Gifford

Publikováno v: Pediatr Dev Pathol

Background Although MYCN (aka N-myc) amplification is reported in ∼20% of neuroblastomas, MYC (aka C-myc) amplification appears to be a rare event in this disease. As of today, only 2 MYC-amplified neuroblastomas have been briefly mentioned in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d473dabcfdf3b90731b693944755b00
https://doi.org/10.1177/1093526617749670

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Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy

Autor: Michelle Haber, Andrew J. Gifford, Jinhan Xie, Nancy Li, Roxanne Cadiz, Toby Trahair, Chelsea Mayoh, Jamie I. Fletcher, Alvin Kamili, Shu Oi Chow, Geoffrey McCowage, Georgina L. Eden, Timothy W. Failes, Robyn Lukeis, Murray D. Norris, Greg M. Arndt

Publikováno v: British Journal of Cancer

BackgroundPredictive preclinical models play an important role in the assessment of new treatment strategies and as avatar models for personalised medicine; however, reliable and timely model generation is challenging. We investigated the feasibility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e476a3885f5995663615134bdde09d
https://pubmed.ncbi.nlm.nih.gov/31919403

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Crizotinib and Surgery for Long-Term Disease Control in Children and Adolescents With ALK-Positive Inflammatory Myofibroblastic Tumors

Autor: Chelsea Mayoh, Mitali Fadia, James Blackburn, Roderick Walker, Ashleigh M. Fordham, Draga Barbaric, Santosh Valvi, Toby Trahair, Andrew C. Wood, Glenn M. Marshall, Tim R. Mercer, Karen L. MacKenzie, Robyn Lukeis, Erin E. Heyer, Andrew J. Gifford

Publikováno v: JCO Precision Oncology

PURPOSE Before anaplastic lymphoma kinase (ALK) inhibitors, treatment options for ALK-positive inflammatory myofibroblastic tumors (AP-IMTs) were unsatisfactory. We retrospectively analyzed the outcome of patients with AP-IMT treated with crizotinib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a4ca90769acf0f6a3bc996b6f296ff
http://europepmc.org/articles/PMC7446396

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Abstract 2884: Establishment of patient-derived xenograft models for high-risk neuroblastoma

Autor: Nancy Li, Jamie I. Fletcher, Murray D. Norris, Jinhan Xie, Geoffrey McCowage, Georgina L. Eden, Andrew J. Gifford, Alvin Kamili, Chelsea Mayoh, Robyn Lukeis, Michelle Haber, Toby Trahair

Publikováno v: Cancer Research. 79:2884-2884

Background: High-risk neuroblastoma (HR-NB) accounts for 15% of all pediatric oncology deaths, with long-term survival approximately 50%. Predictive preclinical models play an important role in the assessment of new treatment strategies and as avatar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2b81bc1c1bfa27ec6b9b8081e449f9f
https://doi.org/10.1158/1538-7445.am2019-2884

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Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases

Publikováno v: Cold Spring Harbor Molecular Case Studies

Adrenocortical carcinoma is a rare malignancy with a poor prognosis and few treatment options. Molecular characterization of this cancer remains limited. We present a case of an adrenocortical carcinoma (ACC) in a 37-yr-old female, with dual lung met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d600d49eb767fe4128c2dfac5a82eb8e
https://doi.org/10.1101/mcs.a003764

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