Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Robyn L. Rairigh"'
NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulation
Autor:
Laurent Storme, Thomas A. Parker, John Kinsella, Robyn L. Rairigh, Steven H. Abman, Theresa R. Grover, Jeanne Zenge
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 281:L1157-L1163
Nitric oxide (NO) and prostacyclin (PGI2) are potent fetal pulmonary vasodilators, but their relative roles and interactions in the regulation of the perinatal pulmonary circulation are poorly understood. We compared the separate and combined effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77345d03e3aacedb53dae557030a29f4
https://doi.org/10.1152/ajplung.2001.281.5.l1157
https://doi.org/10.1152/ajplung.2001.281.5.l1157
Publikováno v:
Circulation Research. 88:721-726
Abstract —To determine whether type II nitric oxide synthase (NOS II) contributes to the NO-mediated fall in pulmonary vascular resistance (PVR) at birth, we studied the effects of selective NOS II antagonists N -(3-aminomethyl) benzylacetamidine d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510d6daceba0e53fdf4e43e8f9af099c
https://doi.org/10.1161/hh0701.088683
https://doi.org/10.1161/hh0701.088683
Autor:
Thomas A. Parker, Timothy D. Le Cras, Laurent Storme, Robyn L. Rairigh, John Kinsella, Steven H. Abman, Malathi Jakkula
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 276:L513-L521
Recent studies have suggested that type II (inducible) nitric oxide (NO) synthase (NOS II) is present in the fetal lung, but its physiological roles are uncertain. Whether NOS II activity contributes to the NO-mediated fall in pulmonary vascular resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57e0508e3143ace2656cb65c8ad293a
https://doi.org/10.1152/ajplung.1999.276.3.l513
https://doi.org/10.1152/ajplung.1999.276.3.l513
Publikováno v:
Pediatric Research. 45:425-431
In vitro studies have suggested that pulmonary arteries can exhibit a myogenic response and that this myogenic response may be potent during the perinatal period. However, whether a myogenic response can be demonstrated to exist in vivo and the poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d2a9088d38f0b69cd25283986131aa
https://doi.org/10.1203/00006450-199903000-00022
https://doi.org/10.1203/00006450-199903000-00022
Autor:
John Kinsella, I D Fan, T. D. Le Cras, Robyn L. Rairigh, D. Dunbar Ivy, Marilee P Horan, Gresham T. Richter, Steven H. Abman
Publikováno v:
Journal of Clinical Investigation. 101:15-21
Nitric oxide (NO) produced by NO synthase (NOS) modulates fetal pulmonary vascular tone and contributes to the fall in pulmonary vascular resistance (PVR) at birth. Although the inducible (type II) NOS isoform is present in human and rat fetal lungs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10258b5c86d835f0c5322fc8a27ca6c3
https://doi.org/10.1172/jci1228
https://doi.org/10.1172/jci1228
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 282(1)
We hypothesized that altered vasoreactivity in perinatal pulmonary hypertension (PH) is characterized by abnormal responses to hemodynamic stress, including the loss of flow-induced vasodilation and an augmented myogenic response. Therefore, we studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f567e13366abb11729ac24268baefd0
https://pubmed.ncbi.nlm.nih.gov/11741816
https://pubmed.ncbi.nlm.nih.gov/11741816
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 278(4)
As observed with nitric oxide (NO), carbon monoxide (CO) binds and may activate soluble guanylate cyclase and increase cGMP levels in smooth muscle cells in vitro. Because inhaled NO (INO) causes potent and sustained pulmonary vasodilation, we hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0b67791d80fe2b6a4b7f1df6a1f2d3
https://pubmed.ncbi.nlm.nih.gov/10749755
https://pubmed.ncbi.nlm.nih.gov/10749755
Autor:
M. Jakkula, Laurent Storme, T. D. Le Cras, Robyn L. Rairigh, Thomas A. Parker, Neil E. Markham, Steven H. Abman
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 278(1)
Nitric oxide (NO) is produced by NO synthase (NOS) and contributes to the regulation of vascular tone in the perinatal lung. Although the neuronal or type I NOS (NOS I) isoform has been identified in the fetal lung, it is not known whether NO produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4714c411fa2b37b1fdae0ddc83f012ba
https://pubmed.ncbi.nlm.nih.gov/10645897
https://pubmed.ncbi.nlm.nih.gov/10645897
Autor:
Laurent Storme, Robyn L. Rairigh, David N. Cornfield, John Kinsella, Steven H. Abman, Thomas A. Parker
Publikováno v:
The American journal of physiology. 276(2)
To determine whether K+-channel activation mediates shear stress-induced pulmonary vasodilation in the fetus, we studied the hemodynamic effects of K+-channel blockers on basal pulmonary vascular resistance and on the pulmonary vascular response to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3dd6aadde82a03f41acba90ffdaddf
https://pubmed.ncbi.nlm.nih.gov/9950883
https://pubmed.ncbi.nlm.nih.gov/9950883
Publikováno v:
Pediatric Research. 45:69A-69A
Aminoguanidine, a Selective Type II (Inducible) Nitric Oxide Synthase Antagonist, Attenuates Vasodilation to Birth-Related Stimuli in the Ovine Lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb44d95d305a20dcee63a5f5908f76b9
https://doi.org/10.1203/00006450-199904020-00414
https://doi.org/10.1203/00006450-199904020-00414