Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robyn L Oldfield"'
Autor:
Amy M Smith, E Scott Graham, Sheryl Xia Feng, Robyn L Oldfield, Peter M Bergin, Edward W Mee, Richard L M Faull, Maurice A Curtis, Mike Dragunow
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80463 (2013)
The chemokine Interferon gamma-induced protein 10 (IP-10) and human leukocyte antigen (HLA) are widely used indicators of glial activation and neuroinflammation and are up-regulated in many brain disorders. These inflammatory mediators have been wide
Externí odkaz:
https://doaj.org/article/6016b7af75b44d3d813a101fd060d30e
Autor:
Amy M. Smith, Thomas In-Hyeup Park, Miranda Aalderink, Robyn L. Oldfield, Peter S. Bergin, Edward W. Mee, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The study of microglia isolated from adult human brain tissue provides unique insight into the physiology of these brain immune cells and their role in adult human brain disorders. Reports of microglia in post-mortem adult human brain tissue show reg
Externí odkaz:
https://doaj.org/article/c5eff623830540a29eefa250fa8e6004
Autor:
Leon Smyth, Richard L.M. Faull, Emma L. Scotter, Zoe Woolf, Mike Dragunow, Edward W. Mee, Patrick Schweder, Molly E. V. Swanson, Peter Heppner, Maurice A. Curtis, Clinton Turner, Bernard J H Kim, Robyn L. Oldfield, Thomas I. H. Park
Publikováno v:
Neuro-oncology Advances
Background Microglia and tumor-associated macrophages (TAMs) constitute up to half of the total tumor mass of glioblastomas. Despite these myeloid populations being ontogenetically distinct, they have been largely conflated. Recent single-cell transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f09641363ce7a16a7ec2261967e0c3f
https://doi.org/10.1093/noajnl/vdab031
https://doi.org/10.1093/noajnl/vdab031
Publikováno v:
Journal of Medical Imaging and Radiation Oncology. 60:194-198
Introduction Ductal carcinoma in situ (DCIS) of the breast is commonly treated surgically. The intent of this study was to evaluate whether preoperative MRI could add to mammography in predicting the extent of the disease. Methods A series of patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b77428080bbf66232e47ff56bbb892f6
https://doi.org/10.1111/1754-9485.12430
https://doi.org/10.1111/1754-9485.12430
Autor:
Mike Dragunow, Peter Bergin, Amy M. Smith, Hannah M. Gibbons, Edward W. Mee, Richard L.M. Faull, Robyn L. Oldfield
Publikováno v:
Glia. 61:929-942
Microglia are the predominant resident immune cells of the brain and can assume a range of phenotypes. They are critical for normal brain development and function but can also contribute to many disease processes. Although they are widely studied, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f51e4209194f72efe8137c131054543a
https://doi.org/10.1002/glia.22486
https://doi.org/10.1002/glia.22486
Autor:
Robyn L. Oldfield, Amy M. Smith, Mike Dragunow, Maurice A. Curtis, Hannah M. Gibbons, Edward W. Mee, Richard L.M. Faull, Peter Bergin
Publikováno v:
Journal of Neuroinflammation
Background Microglia are the primary immune cells of the brain whose phenotype largely depends on their surrounding micro-environment. Microglia respond to a multitude of soluble molecules produced by a variety of brain cells. Macrophage colony-stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5da76673b2ba6dd82087fb748ebded2
https://ora.ox.ac.uk/objects/uuid:f8da31ff-c9a2-45dc-a008-52fa42b98c6c
https://ora.ox.ac.uk/objects/uuid:f8da31ff-c9a2-45dc-a008-52fa42b98c6c
Autor:
Mike Dragunow, Leon Smyth, Justin Rustenhoven, Deidre Jansson, Natacha Coppieters, Emma L. Scotter, Richard L.M. Faull, Edward W. Mee, Robyn L. Oldfield, E. Scott Graham, Peter S. Bergin
Publikováno v:
Journal of Neuroinflammation
Background Neuroinflammation and blood-brain barrier (BBB) disruption are common features of many brain disorders, including Alzheimer’s disease, epilepsy, and motor neuron disease. Inflammation is thought to be a driver of BBB breakdown, but the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9eca0e9b40c4babcd82c33c771c1e3
https://pubmed.ncbi.nlm.nih.gov/27654972
https://pubmed.ncbi.nlm.nih.gov/27654972
Autor:
Richard L.M. Faull, Thomas I. H. Park, P. Rod Dunbar, Justin Rustenhoven, Anna E. S. Brooks, Mike Dragunow, Sheryl Feng, Edward W. Mee, Maurice A. Curtis, Hector J. Monzo, Robyn L. Oldfield, Vaughan Feisst, E. Scott Graham, Peter S. Bergin
Publikováno v:
Scientific Reports
The human brain is a highly vascular organ in which the blood-brain barrier (BBB) tightly regulates molecules entering the brain. Pericytes are an integral cell type of the BBB, regulating vascular integrity, neuroinflammation, angiogenesis and wound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3c4f02754cce2df2609c3acb602b14
http://europepmc.org/articles/PMC4877602
http://europepmc.org/articles/PMC4877602
Autor:
Edward W. Mee, Hannah M. Gibbons, John Scotter, Justin Rustenhoven, Richard L.M. Faull, Jason Correia, Thomas I. H. Park, Patrick Schweder, Robyn L. Oldfield, Mike Dragunow, Peter S. Bergin, E. Scott Graham, Amy M. Smith, Maurice A. Curtis
Publikováno v:
Scientific Reports
Microglia, the resident macrophages of the central nervous system play vital roles in brain homeostasis through clearance of pathogenic material. Microglia are also implicated in neurological disorders through uncontrolled activation and inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8581ed2fce6d87997f18d31d46471cd8
Autor:
Dan T. Kho, Mike Dragunow, Maurice A. Curtis, Deidre Jansson, Edward W. Mee, Emma L. Scotter, Thomas I. H. Park, Peter S. Bergin, Justin Rustenhoven, Scott E. Graham, Robyn L. Oldfield, Richard L.M. Faull
Publikováno v:
Scientific Reports
Neuroinflammation contributes to the pathogenesis of several neurological disorders and pericytes are implicated in brain inflammatory processes. Cellular inflammatory responses are orchestrated by transcription factors but information on transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544a42cc9e2d3604c1134a45e127b2ed