Výsledky vyhledávání - "Robyn K. Chiswell"

A sensitive and specific assay for glutathione with potential application to glutathione disulphide, using high-performance liquid chromatography–tandem mass spectrometry

Autor: Ross Norris, Michael R. Moore, Alan A. Seawright, Glen R. Shaw, Robyn K. Chiswell, Geoffrey K. Eaglesham, M. J. Smith

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 762:17-23

We have utilised the combination of sensitivity and specificity afforded by coupling high-performance liquid chromatography (HPLC) to a tandem mass spectrometer (MS-MS) to produce an assay which is suitable for assaying glutathione (GSH) concentratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9cfea51aa53f38d217993d7b9cb6d3b
https://doi.org/10.1016/s0378-4347(01)00304-8

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Extraction and purification of the zwitterions cylindrospermopsin and deoxycylindrospermopsin fromCylindrospermopsis raciborskii

Autor: P. Senogles, Michael R. Moore, Ross Norris, B. Davis, M. J. Smith, Robyn K. Chiswell, Geoff Eaglesham, A. A. Seawright, Glendon Reginald Shaw

Publikováno v: Environmental Toxicology. 16:391-396

The hepatotoxin cylindrospermopsin (CYN) has been isolated from the cyanobacterium Cylindrospermopsis raciborskii (C. raci.). Efforts to study this toxin have been hampered by the time-consuming requirement to extract it from cultures of the organism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150a8f3c8256d8d8dc8465503db3ff5a
https://doi.org/10.1002/tox.1048

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Distribution of14C cylindrospermopsinin vivo in the mouse

Autor: Michael R. Moore, R.G.L. Norris, Robyn K. Chiswell, M. J. Smith, Glendon Reginald Shaw, A. A. Seawright

Publikováno v: Environmental Toxicology. 16:498-505

Radiolabelled C-14 cylindrospermopsin (CYN) has been prepared and used to investigate the distribution and excretion of CYN in vivo in male Quackenbush mice. At a dose of 0.2 mg/kg (i.e., approx. median lethal dose) the following mean (SID) urinary a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8ea1c2ef9128c52ff5698d3753c139d
https://doi.org/10.1002/tox.10008

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Degradation of the cyanobacterial toxin cylindrospermopsin, from Cylindrospermopsis raciborskii, by chlorination

Autor: Glendon Reginald Shaw, Ross Norris, M. J. Smith, P. Senogles, Ross Sadler, Jochen F. Mueller, Robyn K. Chiswell, Geoff Eaglesham

Publikováno v: Toxicon. 38:1203-1213

Cylindrospermopsin, a potent cyanobacterial toxin produced by Cylindrospermopsis raciborskii and other cyanobacteria, is regularly found in water supplies of Queensland, Australia. This study focussed on the effectiveness of chlorination as a water t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa87de3c2ae33d55007b8fce72c0ae5
https://doi.org/10.1016/s0041-0101(99)00210-x

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Stability of cylindrospermopsin, the toxin from the cyanobacterium,Cylindrospermopsis raciborskii: Effect of pH, temperature, and sunlight on decomposition

Autor: Michael R. Moore, Alan A. Seawright, M. J. Smith, Ross Norris, Glen R. Shaw, Robyn K. Chiswell, Geoff Eaglesham

Publikováno v: Environmental Toxicology. 14:155-161

Cylindrospermopsin is a powerful hepatotoxin produced by the cyanobacterium Cylindrospermopsis raciborskii. It is considered a potential threat to livestock, wildlife, and humans, and is the suspected cause of an outbreak of hepatoenteritis on Palm I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::242af2d60719abc0d94ace0445b66f89
https://doi.org/10.1002/(sici)1522-7278(199902)14:1<155::aid-tox20>3.0.co

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Blooms of the cylindrospermopsin containing cyanobacterium,Aphanizomenon ovalisporum (Forti), in newly constructed lakes, Queensland, Australia

Autor: M. J. Smith, Glen R. Shaw, Geoffrey K. Eaglesham, Robyn K. Chiswell, Ross Norris, Assaf Sukenik, Michael R. Moore, Alan A. Seawright, Adi Livne

Publikováno v: Environmental Toxicology. 14:167-177

The cyanobacterium, Aphanizomenon ovalisporum (Forti) is reported herein for the first time in Australia. Its distribution appears to be restricted to an isolated subtropical region which has distinctive water quality parameters including ready avail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::669ebaec0613727ce3e6c161e951ed72
https://doi.org/10.1002/(sici)1522-7278(199902)14:1<167::aid-tox22>3.0.co

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The oral toxicity for mice of the tropical cyanobacteriumCylindrospermopsis raciborskii (Woloszynska)

Autor: M. J. Smith, Glen R. Shaw, Alan A. Seawright, Ross Norris, Robyn K. Chiswell, Christopher C. Nolan, Michael R. Moore

Publikováno v: Environmental Toxicology. 14:135-142

Exposure of humans and domestic animals to Cylindrospermopsis raciborskii and its associated toxin cylindrospermopsin in their drinking water will normally be by ingestion. Studies of the cyanobacterium to date have involved dosing mice by the intrap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad98a3a34de117835bdbe5674bdd81bc
https://doi.org/10.1002/(sici)1522-7278(199902)14:1<135::aid-tox17>3.0.co

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Use of HPLC-MS/MS to monitor cylindrospermopsin, a blue-green algal toxin, for public health purposes

Autor: Ross Norris, Michael R. Moore, Bradley C. Davis, Alan A. Seawright, Robyn K. Chiswell, M. J. Smith, Geoffrey K. Eaglesham, Glen R. Shaw, Gerard Neville

Publikováno v: Environmental Toxicology. 14:151-154

Increasing reports of blooms of the blue-green alga Cylindrospermopsis raciborskii (C. raciborskii), which contains the hepatotoxic alkaloid cylindrospermopsin (CYN), have led to public health concerns in Australia. The toxicology of CYN appears comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aef733ebc7dc7a7d795feb3d4f3f9a66
https://doi.org/10.1002/(sici)1522-7278(199902)14:1<151::aid-tox19>3.0.co

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Deoxycylindrospermopsin, an analog of cylindrospermopsin fromCylindrospermopsis raciborskii

Autor: M. J. Smith, Glen R. Shaw, Michael R. Moore, Alan A. Seawright, Greg Pierens, Ross Norris, Geoffrey K. Eaglesham, Robyn K. Chiswell

Publikováno v: Environmental Toxicology. 14:163-165

Cylindrospermopsin (CYN) is a hepatotoxic alkaloid found in the blue-green alga Cylindrospermopsis raciborskii (C. raciborskii). Data indicating CYN alone does not account for the toxicity of freeze dried cultures of C. raciborskii have been presente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e373364eed996153742b52c8b97620e
https://doi.org/10.1002/(sici)1522-7278(199902)14:1<163::aid-tox21>3.0.co

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Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse

Autor: A. A. Seawright, M. J. Smith, Glendon Reginald Shaw, Robyn K. Chiswell, Geoff Eaglesham, Michael R. Moore, Ross Norris, P. Senogles

Publikováno v: Toxicon : official journal of the International Society on Toxinology. 40(4)

Cylindrospermopsin (CYN) is a hepatotoxin isolated from the blue-green alga Cylindrospermopsis raciborskii. The role of both glutathione (GSH) and the cytochrome P450 enzyme system (P450) in the mechanism of toxicity of CYN has been previously invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471c59a30caa522e65c9681071377e91
https://pubmed.ncbi.nlm.nih.gov/11738241

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