Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Robyn D Moir"'
Publikováno v:
eLife, Vol 13 (2024)
Pathogenic variants in subunits of RNA polymerase (Pol) III cause a spectrum of Polr3-related neurodegenerative diseases including 4H leukodystrophy. Disease onset occurs from infancy to early adulthood and is associated with a variable range and sev
Externí odkaz:
https://doaj.org/article/575c21036b004d00959ad667c2e61ab8
Autor:
Sayani Dasgupta, Ciyu Yang, Leandro M Castro, Alexandre K Tashima, Emer S Ferro, Robyn D Moir, Ian M Willis, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163312 (2016)
Peptides function as signaling molecules in species as diverse as humans and yeast. Mass spectrometry-based peptidomics techniques provide a relatively unbiased method to assess the peptidome of biological samples. In the present study, we used a qua
Externí odkaz:
https://doaj.org/article/963777c8a9844402ae8af96bb042329c
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127225 (2015)
The production of ribosomes and tRNAs for protein synthesis has a high energetic cost and is under tight transcriptional control to ensure that the level of RNA synthesis is balanced with nutrient availability and the prevailing environmental conditi
Externí odkaz:
https://doaj.org/article/d7c45c741b0346118bbb16843227fa66
Autor:
Robyn D Moir, Ian M Willis
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004896 (2015)
Externí odkaz:
https://doaj.org/article/a4dfa40caa58460db4501dbdc08e8e75
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002890 (2012)
The ability to store nutrients in lipid droplets (LDs) is an ancient function that provides the primary source of metabolic energy during periods of nutrient insufficiency and between meals. The Fat storage-Inducing Transmembrane (FIT) proteins are c
Externí odkaz:
https://doaj.org/article/260f43f426b1432e853c22de734f1067
Autor:
Ian M Willis, Gordon Chua, Amy H Tong, Renee L Brost, Timothy R Hughes, Charles Boone, Robyn D Moir
Publikováno v:
PLoS Genetics, Vol 4, Iss 7, p e1000112 (2008)
Transcriptional repression of ribosomal components and tRNAs is coordinately regulated in response to a wide variety of environmental stresses. Part of this response involves the convergence of different nutritional and stress signaling pathways on M
Externí odkaz:
https://doaj.org/article/7513e11ca92043a9a8bdb75e8f8376b3
Autor:
Robyn D. Moir, Catherine Moret, Gilles Willemin, Nouria Hernandez, François Mange, Ian M. Willis, Nicolas Bonhoure, Viviane Praz
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific reports, vol. 10, no. 1, pp. 11956
Scientific Reports
Scientific reports, vol. 10, no. 1, pp. 11956
Maf1−/− mice are lean, obesity-resistant and metabolically inefficient. Their increased energy expenditure is thought to be driven by a futile RNA cycle that reprograms metabolism to meet an increased demand for nucleotides stemming from the dere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ec619a3d3924318fe2bedcd2e87051
http://link.springer.com/article/10.1038/s41598-020-68665-0
http://link.springer.com/article/10.1038/s41598-020-68665-0
Autor:
Christoph W. Müller, Wim J. H. Hagen, Rene Wetzel, Robyn D. Moir, Matthias K. Vorländer, Florence Baudin, Ian M. Willis
Publikováno v:
Nature structural & molecular biology
Maf1 is a conserved inhibitor of RNA polymerase III (Pol III) that influences phenotypes ranging from metabolic efficiency to lifespan. Here, we present a 3.3-A-resolution cryo-EM structure of yeast Maf1 bound to Pol III, establishing that Maf1 seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ba72c81430b9b3ddf1d58920615822
http://europepmc.org/articles/PMC7104376
http://europepmc.org/articles/PMC7104376
Autor:
Claudia L. Kleinman, Bernard Brais, Marie Josée Dicaire, Maxime Pinard, Marie-Soleil Gauthier, Roxanne Larivière, Christian Poitras, Karine Choquet, Nicolas Sgarioto, Sharon Yang, Ian M. Willis, Benoit Coulombe, Robyn D. Moir
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-10 (2019)
Molecular Brain
Molecular Brain
Recessive mutations in the ubiquitously expressed POLR3A and POLR3B genes are the most common cause of POLR3-related hypomyelinating leukodystrophy (POLR3-HLD), a rare childhood-onset disorder characterized by deficient cerebral myelin formation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a45b70d5c7930b6d296dd5488e49890
http://link.springer.com/article/10.1186/s13041-019-0479-7
http://link.springer.com/article/10.1186/s13041-019-0479-7
Autor:
Bridget Shafit-Zagardo, Min Hui Cui, Emilio Merheb, Robyn D. Moir, Maria Gulinello, Ian M. Willis, Juwen C. DuBois, Craig A. Branch
Publikováno v:
Proc Natl Acad Sci U S A
RNA polymerase (Pol) III synthesizes abundant short non-coding RNAs that have essential functions in protein synthesis, secretion and other processes. Despite the ubiquitous functions of these RNAs, mutations in Pol III subunits cause Pol III-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e517ac91029ad804c2282c83957af67a
https://doi.org/10.1101/2020.12.09.418657
https://doi.org/10.1101/2020.12.09.418657
