Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Robyn, Miller"'
Autor:
Shailendra Kumar Verma, Fernanda Ana-Sosa-Batiz, Julia Timis, Norazizah Shafee, Erin Maule, Paolla Beatriz Almeida Pinto, Chris Conner, Kristen M. Valentine, Dale O. Cowley, Robyn Miller, Annie Elong Ngono, Linda Tran, Krithik Varghese, Rúbens Prince Dos Santos Alves, Kathryn M. Hastie, Erica Ollmann Saphire, David R. Webb, Kurt Jarnagin, Kenneth Kim, Sujan Shresta
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105361- (2024)
Summary: Background: Mouse models that recapitulate key features of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are important tools for understanding complex interactions between host genetics, immune responses, and SARS-Co
Externí odkaz:
https://doaj.org/article/04220e5ef32e4419879fefba16782ce9
Autor:
Xiaodi Yu, Rosalie E. Matico, Robyn Miller, Dhruv Chauhan, Bertrand Van Schoubroeck, Karolien Grauwen, Javier Suarez, Beth Pietrak, Nandan Haloi, Yanting Yin, Gary John Tresadern, Laura Perez-Benito, Erik Lindahl, Astrid Bottelbergs, Daniel Oehlrich, Nina Van Opdenbosch, Sujata Sharma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The NACHT-, leucine-rich-repeat-, and pyrin domain-containing protein 3 (NLRP3) is a critical intracellular inflammasome sensor and an important clinical target against inflammation-driven human diseases. Recent studies have elucidated its t
Externí odkaz:
https://doaj.org/article/7f229443efb44bc9b6f041484b3699ef
Autor:
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael P. Maher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants of gating modulation by d
Externí odkaz:
https://doaj.org/article/7532453b22314d01ada9b275f434a0b8
Autor:
Rúbens Prince dos Santos Alves, Julia Timis, Robyn Miller, Kristen Valentine, Paolla Beatriz Almeida Pinto, Andrew Gonzalez, Jose Angel Regla-Nava, Erin Maule, Michael N. Nguyen, Norazizah Shafee, Sara Landeras-Bueno, Eduardo Olmedillas, Brett Laffey, Katarzyna Dobaczewska, Zbigniew Mikulski, Sara McArdle, Sarah R. Leist, Kenneth Kim, Ralph S. Baric, Erica Ollmann Saphire, Annie Elong Ngono, Sujan Shresta
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract SARS-CoV-2-reactive T cells are detected in some healthy unexposed individuals. Human studies indicate these T cells could be elicited by the common cold coronavirus OC43. To directly test this assumption and define the role of OC43-elicited
Externí odkaz:
https://doaj.org/article/9ae5cf7c26864a23845ea55a62b14b62
Autor:
Xiaodi Yu, Pravien Abeywickrema, Brecht Bonneux, Ishani Behera, Brandon Anson, Edgar Jacoby, Amy Fung, Suraj Adhikary, Anusarka Bhaumik, Rodrigo J. Carbajo, Suzanne De Bruyn, Robyn Miller, Aaron Patrick, Quyen Pham, Madison Piassek, Nick Verheyen, Afzaal Shareef, Priscila Sutto-Ortiz, Nina Ysebaert, Herman Van Vlijmen, Tim H. M. Jonckers, Florence Herschke, Jason S. McLellan, Etienne Decroly, Rachel Fearns, Sandrine Grosse, Dirk Roymans, Sujata Sharma, Peter Rigaux, Zhinan Jin
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract The respiratory syncytial virus polymerase complex, consisting of the polymerase (L) and phosphoprotein (P), catalyzes nucleotide polymerization, cap addition, and cap methylation via the RNA dependent RNA polymerase, capping, and Methyltran
Externí odkaz:
https://doaj.org/article/155faab50b5b48fe954bff5b07e1b8ac
Autor:
Kathryn M. Hastie, Xiaoying Yu, Fernanda Ana-Sosa-Batiz, Dawid S. Zyla, Stephanie S. Harkins, Chitra Hariharan, Hal Wasserman, Michelle A. Zandonatti, Robyn Miller, Erin Maule, Kenneth Kim, Kristen M. Valentine, Sujan Shresta, Erica Ollmann Saphire
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112421- (2023)
Summary: Therapeutic antibodies are an important tool in the arsenal against coronavirus infection. However, most antibodies developed early in the pandemic have lost most or all efficacy against newly emergent strains of severe acute respiratory syn
Externí odkaz:
https://doaj.org/article/05a63022e4b143f984c77e5eae90c9db
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionResting-state functional magnetic resonance imaging (rs-fMRI) is a powerful tool for assessing functional brain connectivity. Recent studies have focused on shorter-term connectivity and dynamics in the resting state. However, most of the
Externí odkaz:
https://doaj.org/article/2d4fa8b3d3e14772ba48d308c6929391
Autor:
Victor M. Vergara, Martin Norgaard, Robyn Miller, Roger E. Beaty, Kiran Dhakal, Mukesh Dhamala, Vince D. Calhoun
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract One of the most complex forms of creativity is musical improvisation where new music is produced in real time. Brain behavior during music production has several dimensions depending on the conditions of the performance. The expression of cr
Externí odkaz:
https://doaj.org/article/8f23d51019ca448d9958935970478b6f
Autor:
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, David Lin, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael Maher
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Liu et al study the molecular and structural mechanism of the modulation of ASIC1 channel gating using functional, crystallographic, computational and mutational approaches. They identify small molecules that allosterically stabilize the closed state
Externí odkaz:
https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
Autor:
Zening Fu, Armin Iraji, Jessica A. Turner, Jing Sui, Robyn Miller, Godfrey D. Pearlson, Vince D. Calhoun
Publikováno v:
NeuroImage, Vol 224, Iss , Pp 117385- (2021)
The human brain is a dynamic system that incorporates the evolution of local activities and the reconfiguration of brain interactions. Reoccurring brain patterns, regarded as “brain states”, have revealed new insights into the pathophysiology of
Externí odkaz:
https://doaj.org/article/713c286d331942c288553c036d29521b