Výsledky vyhledávání - "Robson Q Monteiro"

Akademický článek

In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus.

Autor: Teresa C Assumpção, Dongying Ma, Daniella M Mizurini, R Manjunatha Kini, José M C Ribeiro, Michail Kotsyfakis, Robson Q Monteiro, Ivo M B Francischetti

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004298 (2016)

BACKGROUND:Hematophagous mosquitos and ticks avoid host hemostatic system through expression of enzyme inhibitors targeting proteolytic reactions of the coagulation and complement cascades. While most inhibitors characterized to date were found in th

Externí odkaz: https://doaj.org/article/ba3e1106f28645379f8830423cbc6335

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Akademický článek

Identification and Mechanistic Analysis of a Novel Tick-Derived Inhibitor of Thrombin.

Autor: Willy Jablonka, Michalis Kotsyfakis, Daniella M Mizurini, Robson Q Monteiro, Jan Lukszo, Steven K Drake, José M C Ribeiro, John F Andersen

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0133991 (2015)

A group of peptides from the salivary gland of the tick Hyalomma marginatum rufipes, a vector of Crimean Congo hemorrhagic fever show weak similarity to the madanins, a group of thrombin-inhibitory peptides from a second tick species, Haemaphysalis l

Externí odkaz: https://doaj.org/article/97b66389596c49fbb9ad46d643a9742b

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Akademický článek

Salivary Thromboxane A2-Binding Proteins from Triatomine Vectors of Chagas Disease Inhibit Platelet-Mediated Neutrophil Extracellular Traps (NETs) Formation and Arterial Thrombosis.

Autor: Daniella M Mizurini, Jorgeane S Aslan, Tainá Gomes, Dongying Ma, Ivo M B Francischetti, Robson Q Monteiro

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003869 (2015)

BACKGROUND:The saliva of blood-feeding arthropods contains a notable diversity of molecules that target the hemostatic and immune systems of the host. Dipetalodipin and triplatin are triatomine salivary proteins that exhibit high affinity binding to

Externí odkaz: https://doaj.org/article/92ab2eff538c485f8e66df5c687d7ad0

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Akademický článek

Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis.

Autor: Michael Waisberg, Alvaro Molina-Cruz, Daniella M Mizurini, Nidhi Gera, Beatriz C Sousa, Dongying Ma, Ana C Leal, Tainá Gomes, Michalis Kotsyfakis, José M C Ribeiro, Jan Lukszo, Karine Reiter, Stephen F Porcella, Carlo J Oliveira, Robson Q Monteiro, Carolina Barillas-Mury, Susan K Pierce, Ivo M B Francischetti

Publikováno v: PLoS Pathogens, Vol 10, Iss 9, p e1004338 (2014)

Invasion of mosquito salivary glands (SGs) by Plasmodium falciparum sporozoites is an essential step in the malaria life cycle. How infection modulates gene expression, and affects hematophagy remains unclear.Using Affimetrix chip microarray, we foun

Externí odkaz: https://doaj.org/article/e7d7fadfcbb4447a92fa54705013a1c9

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Akademický článek

Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi.

Autor: Felipe Gazos-Lopes, Mauricio M Oliveira, Lucas V B Hoelz, Danielle P Vieira, Alexandre F Marques, Ernesto S Nakayasu, Marta T Gomes, Nasim G Salloum, Pedro G Pascutti, Thaïs Souto-Padrón, Robson Q Monteiro, Angela H Lopes, Igor C Almeida

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e3077 (2014)

Trypanosoma cruzi is the causative agent of the life-threatening Chagas disease, in which increased platelet aggregation related to myocarditis is observed. Platelet-activating factor (PAF) is a potent intercellular lipid mediator and second messenge

Externí odkaz: https://doaj.org/article/8162a50a9a61444f93aab6e03d3cba54

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Akademický článek

Platelet activating factor blocks interkinetic nuclear migration in retinal progenitors through an arrest of the cell cycle at the S/G2 transition.

Autor: Lucianne Fragel-Madeira, Tamara Meletti, Rafael M Mariante, Robson Q Monteiro, Marcelo Einicker-Lamas, Robson R Bernardo, Angela H Lopes, Rafael Linden

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16058 (2011)

Nuclear migration is regulated by the LIS1 protein, which is the regulatory subunit of platelet activating factor (PAF) acetyl-hydrolase, an enzyme complex that inactivates the lipid mediator PAF. Among other functions, PAF modulates cell proliferati

Externí odkaz: https://doaj.org/article/c8e57629ea3647638014adfd18172837

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Akademický článek

Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies.

Autor: Vivian de Almeira Silva, Maria Thereza Cargnelutti, Guilherme M Giesel, Leonardo C Palmieri, Robson Q Monteiro, Hugo Verli, Luis Mauricio T R Lima

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24735 (2011)

Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study, we address the effects of ligand site recognition by alpha-thrombin on conformation and energetics in solution. Active site occupation induces large changes

Externí odkaz: https://doaj.org/article/5f9f52ec22f549279de271b49b449387

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