A Mycobacterium leprae Hsp65 mutant as a candidate for mitigating lupus aggravation in mice.

Autor: Eliana B Marengo, Luciana V de Moraes, Robson L Melo, Andrea Balan, Beatriz L Fernandes, Denise V Tambourgi, Luiz Vicente Rizzo, Osvaldo Augusto Sant'Anna

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24093 (2011)

Hsp60 is an abundant and highly conserved family of intracellular molecules. Increased levels of this family of proteins have been observed in the extracellular compartment in chronic inflammation. Administration of M. leprae Hsp65 [WT] in [NZBxNZW]F

Externí odkaz: https://doaj.org/article/25da004a57d446339e61d6956b98e5cb

A Lipocalin-Derived Peptide Modulating Fibroblasts and Extracellular Matrix Proteins

Autor: Linda Christian Carrijo-Carvalho, Durvanei A. Maria, Janaina S. Ventura, Kátia L. P. Morais, Robson L. Melo, Consuelo Junqueira Rodrigues, Ana Marisa Chudzinski-Tavassi

Publikováno v: Journal of Toxicology, Vol 2012 (2012)

Lipocalin family members have been implicated in development, regeneration, and pathological processes, but their roles are unclear. Interestingly, these proteins are found abundant in the venom of the Lonomia obliqua caterpillar. Lipocalins are β-b

Externí odkaz: https://doaj.org/article/caacfd716c8f444fbede69b9017ac1f4

Proline rich-oligopeptides: Diverse mechanisms for antihypertensive action

Autor: Danielle Ianzer, Juliano R. Guerreiro, Robson A.S. Santos, Katia L.P. Morais, Henning Ulrich, Claudiana Lameu, Robson L. Melo, José Rodolfo R. Miranda

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Bradykinin-potentiating peptides from Bothrops jararaca (Bj) discovered in the early 1960s, were the first natural inhibitors of the angiotensin-converting enzyme (ACE). These peptides belong to a large family of snake venom proline-rich oligopeptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7648e320e2cebdf832d2ce712b4bae75
https://doi.org/10.1016/j.peptides.2013.07.016

Longipin: An Amyloid Antimicrobial Peptide from the Harvestman Acutisoma longipes (Arachnida: Opiliones) with Preferential Affinity for Anionic Vesicles

Autor: Raphael S. R. Sayegh, Isabel de Fátima Correia Batista, Karin A. Riske, Pedro Ismael da Silva Junior, Sirlei Daffre, Robson L. Melo, Guillermo G. Montich

Publikováno v: Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
PLoS ONE
PLoS ONE, Vol 11, Iss 12, p e0167953 (2016)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

In contrast to vertebrate immune systems, invertebrates lack an adaptive response and rely solely on innate immunity in which antimicrobial peptides (AMPs) play an essential role. Most of them are membrane active molecules that are typically unstruct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dc119282a56ae8c1c188878879c619
https://repositorio.unifesp.br/handle/11600/56541

Bradykinin-related peptides in the venom of the solitary wasp Cyphononyx fulvognathus

Autor: Yara Cury, Mirian A. F. Hayashi, Maurício F.M. Machado, I M Conceição, Robson L. Melo, Analue B. Moura, Miki Hisada, Gisele Picolo, Maria Teresa R. Lima-Landman, Juliana Mozer Sciani, Katsuhiro Konno, Vitor Oliveira

Publikováno v: Biochemical Pharmacology. 79:478-486

Bradykinin (BK) and its related peptides are widely distributed in venomous animals, including wasps. In fact, we have previously purified a novel BK-related peptide (BRP) named Cd -146 and the threonine 6 -bradykinin (Thr 6 -BK) from the venom of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b1d2352697bd6cdc067e4d2c6abb60
https://doi.org/10.1016/j.bcp.2009.08.020