Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Robin van Schendel"'
Autor:
Longjun Pu, Jing Wang, Qiongxuan Lu, Lars Nilsson, Alison Philbrook, Anjali Pandey, Lina Zhao, Robin van Schendel, Alan Koh, Tanara V. Peres, Weheliye H. Hashi, Si Lhyam Myint, Chloe Williams, Jonathan D. Gilthorpe, Sun Nyunt Wai, Andre Brown, Marcel Tijsterman, Piali Sengupta, Johan Henriksson, Changchun Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract G protein-coupled receptors (GPCRs) mediate responses to various extracellular and intracellular cues. However, the large number of GPCR genes and their substantial functional redundancy make it challenging to systematically dissect GPCR fun
Externí odkaz:
https://doaj.org/article/24e1b9e01e0d43e0a19e2412288d53fd
Autor:
Joost Schimmel, Núria Muñoz-Subirana, Hanneke Kool, Robin van Schendel, Sven van der Vlies, Juliette A. Kamp, Femke de Vrij, Steven A. Kushner, Graeme C.M. Smith, Simon J. Boulton, Marcel Tijsterman
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112019- (2023)
Summary: Gene editing through repair of CRISPR-Cas9-induced chromosomal breaks offers a means to correct a wide range of genetic defects. Directing repair to produce desirable outcomes by modulating DNA repair pathways holds considerable promise to i
Externí odkaz:
https://doaj.org/article/2cda6fc70a1649d382e75e95931d82e5
Autor:
Ida Höijer, Anastasia Emmanouilidou, Rebecka Östlund, Robin van Schendel, Selma Bozorgpana, Marcel Tijsterman, Lars Feuk, Ulf Gyllensten, Marcel den Hoed, Adam Ameur
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
CRISPR-Cas9 can introduce unintended off-target effects. Here authors show that unintended mutations produced by in vivo of zebrafish can be inherited by their off-spring.
Externí odkaz:
https://doaj.org/article/c9926fdc297c499ead1e48efd9227591
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Error-prone repair of DNA double-strand breaks have been implied to cause cancer-associated genome alterations, but the mechanism of their formation remains unclear. Here the authors find that DNA polymerase α primase plays part in tandem duplicatio
Externí odkaz:
https://doaj.org/article/3e3f130d195f4ae0b99ff4a7f386fe74
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008759 (2020)
Bases within DNA are frequently damaged, producing obstacles to efficient and accurate DNA replication by replicative polymerases. Translesion synthesis (TLS) polymerases, via their ability to catalyze nucleotide additions to growing DNA chains acros
Externí odkaz:
https://doaj.org/article/634c56af96b14396b33b416a616607b6
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006368 (2016)
For more than half a century, genotoxic agents have been used to induce mutations in the genome of model organisms to establish genotype-phenotype relationships. While inaccurate replication across damaged bases can explain the formation of single nu
Externí odkaz:
https://doaj.org/article/7ab5f38631294058a7176debe29523fa
Autor:
Lejon E. M. Kralemann, Sylvia de Pater, Hexi Shen, Susan L. Kloet, Robin van Schendel, Paul J. J. Hooykaas, Marcel Tijsterman
Publikováno v:
Nature Plants, 8(5), 526-534
Nature Plants, 8(5), 526-+. NATURE PORTFOLIO
Nature Plants, 8(5), 526-+. NATURE PORTFOLIO
Agrobacterium tumefaciens, a pathogenic bacterium capable of transforming plants through horizontal gene transfer, is nowadays the preferred vector for plant genetic engineering. The vehicle for transfer is the T-strand, a single-stranded DNA molecul
Autor:
Niels van Tol, Robin van Schendel, Paul J. J. Hooykaas, Marcel Tijsterman, Alex Bos, Sylvia de Pater, Maartje van Kregten
Publikováno v:
The Plant Journal, 109(1), 112-125
The Plant Journal, 109(1), 112-125. WILEY
The Plant Journal, 109(1), 112-125. WILEY
Agrobacterium tumefaciens-mediated transformation has been for decades the preferred tool to generate transgenic plants. During this process, a T-DNA carrying transgenes is transferred from the bacterium to plant cells, where it randomly integrates i
Publikováno v:
NAR Genomics and Bioinformatics, 4(3). OXFORD UNIV PRESS
Establishing mutational outcomes after genome editing is of increasing importance with the advent of highly efficient genome-targeting tools. Next-generation sequencing (NGS) has become a vital method to investigate the extent of mutagenesis at speci
Autor:
Silvère M. van der Maarel, Mark T. Rogers, Nicol C. Voermans, Robin van Schendel, M. Jeanpierre, Meena Upadhyaya, Pascal Laforêt, David San Leon Granado, Sabrina Sacconi, Rabi Tawil, Nienke van der Stoep, Marianne de Visser, Patrick J. van der Vliet, Baziel G.M. van Engelen, Henk P. J. Buermans, Joost Schimmel, Rudy Van Coster, Richard J.L.F. Lemmers
Publikováno v:
Human Molecular Genetics, 31, 748-760
Human Molecular Genetics, 31(5), 748-760. OXFORD UNIV PRESS
Hum Mol Genet
Human Molecular Genetics, 31, 5, pp. 748-760
Human molecular genetics, 31(5), 748-760. Oxford University Press
Human Molecular Genetics, 31(5), 748-760. OXFORD UNIV PRESS
Hum Mol Genet
Human Molecular Genetics, 31, 5, pp. 748-760
Human molecular genetics, 31(5), 748-760. Oxford University Press
Contains fulltext : 248862.pdf (Publisher’s version ) (Closed access) Facioscapulohumeral muscular dystrophy (FSHD) is an inherited myopathy clinically characterized by weakness in the facial, shoulder girdle and upper a muscles. FSHD is caused by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d238fc435cb03345cb58f5fab0546aa
http://hdl.handle.net/2066/248862
http://hdl.handle.net/2066/248862