High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4+ T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19

Autor: Leon Cords, Maximilian Knapp, Robin Woost, Sophia Schulte, Silke Kummer, Christin Ackermann, Claudia Beisel, Sven Peine, Alexandra Märta Johansson, William Wai-Hung Kwok, Thomas Günther, Nicole Fischer, Melanie Wittner, Marylyn Martina Addo, Samuel Huber, Julian Schulze zur Wiesch

Publikováno v: Viruses, Vol 14, Iss 6, p 1265 (2022)

Here, we longitudinally assessed the ex vivo frequency and phenotype of SARS-CoV-2 membrane protein (aa145–164) epitope-specific CD4+ T-cells of an anti-CD20-treated patient with prolonged viral positivity in direct comparison to an immunocompetent

Externí odkaz: https://doaj.org/article/1e8ef9c65a904696a4ab4d1c8c5d6aa1

Analysis of Co-inhibitory Receptor Expression in COVID-19 Infection Compared to Acute Plasmodium falciparum Malaria: LAG-3 and TIM-3 Correlate With T Cell Activation and Course of Disease

Autor: Marissa Herrmann, Sophia Schulte, Nils H. Wildner, Melanie Wittner, Thomas Theo Brehm, Michael Ramharter, Robin Woost, Ansgar W. Lohse, Thomas Jacobs, Julian Schulze zur Wiesch

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Coronavirus disease 2019 (COVID-19) which is caused by the novel SARS-CoV-2 virus is a severe flu-like illness which is associated with hyperinflammation and immune dysfunction. The virus induces a strong T and B cell response but little is known abo

Externí odkaz: https://doaj.org/article/b6901bc682c24a4b9ef75a609f010189

Frequency of IRF5+ dendritic cells is associated with the TLR7-induced inflammatory cytokine response in SARS-CoV-2 infection

Autor: Leon Cords, Robin Woost, Silke Kummer, Thomas T. Brehm, Stefan Kluge, Stefan Schmiedel, Sabine Jordan, Ansgar W. Lohse, Marcus Altfeld, Marylyn M. Addo, Julian Schulze zur Wiesch, Claudia Beisel

Publikováno v: Cytokine. 162:156109

The SARS-CoV-2 infection leads to enhanced inflammation driven by innate immune responses. Upon TLR7 stimulation, dendritic cells (DC) mediate the production of inflammatory cytokines, and in particular of type I interferons (IFN). Especially in DCs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de1bce5c8d1cd1ab8267a72df018d35
https://doi.org/10.1016/j.cyto.2022.156109

Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML

Autor: Nils H. Wildner, Gabi Vohwinkel, Walter Fiedler, Jasmin Wellbrock, Robin Woost, Eva Tolosa, Franziska Brauneck, Christin Ackermann, Anne Rissiek, J Schulze zur Wiesch, Carsten Bokemeyer, Friedrich Haag

Publikováno v: Oncoimmunology
article-version (VoR) Version of Record
OncoImmunology, Vol 10, Iss 1 (2021)

The inhibitory receptor TIGIT, as well as theectonucleotidases CD39 and CD73 constitute potential exhaustion markers for T cells. Detailed analysis of these markers can shed light into dysregulation of the T-cell response in acute myeloid leukemia (A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368293799549aaf9d1c41ac2aad3331a
http://europepmc.org/articles/PMC8218695

Preclinical toxicity analyses of lentiviral vectors expressing the HIV-1 LTR-specific designer-recombinase Brec1.

Autor: Beschorner, Niklas^1,2,3 (AUTHOR), Künzle, Paul^1,2 (AUTHOR), Voges, Maike^1,3 (AUTHOR), Hauber, Ilona^1,3 (AUTHOR), Indenbirken, Daniela^1,2 (AUTHOR), Nakel, Jacqueline^1,2 (AUTHOR), Virdi, Sanamjeet^1,2 (AUTHOR), Bradtke, Peter⁴ (AUTHOR), Lory, Niels Christian⁴ (AUTHOR), Rothe, Michael⁵ (AUTHOR), Paszkowski-Rogacz, Maciej⁶ (AUTHOR), Buchholz, Frank^3,6 (AUTHOR), Grundhoff, Adam^1,2 (AUTHOR), Schambach, Axel⁵ (AUTHOR), Thirion, Christian⁷ (AUTHOR), Mittrücker, Hans-Willi^4,8 (AUTHOR), Schulze zur Wiesch, Julian^2,9 (AUTHOR), Hauber, Joachim^1,2,3 (AUTHOR), Chemnitz, Jan^1,2,3 (AUTHOR) jan.chemnitz@provirex.de

Publikováno v: PLoS ONE. 3/8/2024, Vol. 19 Issue 3, p1-31. 31p.