The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice

Autor: Léa J. Becker, Clémentine Fillinger, Robin Waegaert, Sarah H. Journée, Pierre Hener, Beyza Ayazgok, Muris Humo, Meltem Karatas, Maxime Thouaye, Mithil Gaikwad, Laetitia Degiorgis, Marie des Neiges Santin, Mary Mondino, Michel Barrot, El Chérif Ibrahim, Gustavo Turecki, Raoul Belzeaux, Pierre Veinante, Laura A. Harsan, Sylvain Hugel, Pierre-Eric Lutz, Ipek Yalcin

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)

Abstract While depression and chronic pain are frequently comorbid, underlying neuronal circuits and their psychopathological relevance remain poorly defined. Here we show in mice that hyperactivity of the neuronal pathway linking the basolateral amy

Externí odkaz: https://doaj.org/article/79edb28876214399bf2915cb6fdcd98c

Longitudinal transcriptomic analysis of altered pathways in a CHMP2Bintron5-based model of ALS-FTD

Autor: Robin Waegaert, Sylvie Dirrig-Grosch, Florian Parisot, Céline Keime, Alexandre Henriques, Jean-Philippe Loeffler, Frédérique René

Publikováno v: Neurobiology of Disease, Vol 136, Iss , Pp 104710- (2020)

Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative diseases with currently no cure. These two diseases share a clinical continuum with overlapping genetic causes. Mutations in the CHMP2B gene are found in patients wit

Externí odkaz: https://doaj.org/article/889466d7b8d340a2a6458e0cb99c65fb

Alteration of the Neuromuscular Junction and Modifications of Muscle Metabolism in Response to Neuron-Restricted Expression of the CHMP2B

Autor: Robin, Waegaert, Sylvie, Dirrig-Grosch, Haoyi, Liu, Marion, Boutry, Ping, Luan, Jean-Philippe, Loeffler, Frédérique, René

Publikováno v: Biomolecules. 12(4)

CHMP2B is a protein that coordinates membrane scission events as a core component of the ESCRT machinery. Mutations in CHMP2B are an uncommon cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two neurodegenerative diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d568f78163d9b2a90ae89dcfc92eadc
https://pubmed.ncbi.nlm.nih.gov/35454086

A transgenic mouse expressing CHMP2Bintron5mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia

Autor: Frédérique René, Aurelia Vernay, Thiebault Lequeu, Robin Waegaert, Béatrice Blot, François Sellal, Jean-Philippe Loeffler, Rémy Sadoul, Valerie Risson, Sylvie Dirrig-Grosch, Ludivine Therreau, Laurent Schaeffer

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, 2016, 25 (15), pp.3341-3360. ⟨10.1093/hmg/ddw182⟩
Human Molecular Genetics, Oxford University Press (OUP), 2016, 25 (15), pp.3341-3360. ⟨10.1093/hmg/ddw182⟩

International audience; Mutations in the charged multivesicular body protein 2B (CHMP2B) are associated with frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and with a mixed ALS-FTD syndrome. To model this syndrome, we generated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3b5d36195b81030584c56d35a074bb
https://doi.org/10.1093/hmg/ddw182