Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Robin Verhaar"'
Autor:
Robin Verhaar, Benjamin Drukarch, John G.J.M. Bol, Cornelis A.M. Jongenelen, René J.P. Musters, Micha M.M. Wilhelmus
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 839-850 (2012)
Parkinson's disease (PD) is characterized by accumulation of α-synuclein aggregates and degeneration of melanized, catecholaminergic neurons. The tissue transglutaminase (tTG) enzyme catalyzes molecular protein cross-linking. In PD, tTG levels are i
Externí odkaz:
https://doaj.org/article/0cd4b15073ca419cbb57cf9a598aba4d
Autor:
Patrick Cras, Jeroen J.M. Hoozemans, Ling Shan, Benjamin Drukarch, Gerda Andringa, Micha M.M. Wilhelmus, John G.J.M. Bol, Robin Verhaar
Publikováno v:
Brain Pathology. 21:130-139
Parkinson's disease (PD) is characterized by the accumulation of α-synuclein aggregates and degeneration of melanized neurons. The tissue transglutaminase (tTG) enzyme catalyzes molecular protein cross-linking. In PD brain, tTG-induced cross-links h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1729db7daf03d65166c61c43111b600
https://doi.org/10.1111/j.1750-3639.2010.00429.x
https://doi.org/10.1111/j.1750-3639.2010.00429.x
Autor:
Dirk de Korte, Mark H. Ginsberg, David W. C. Dekkers, Robin Verhaar, Arthur J. Verhoeven, Iris M. De Cuyper
Publikováno v:
Blood, 112(13), 4935-4939. American Society of Hematology
UV-C irradiation has been shown to be effective for pathogen reduction in platelet concentrates, but preliminary work indicated that UV-C irradiation of platelets can induce platelet aggregation. In this study, the mechanism underlying this phenomeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da8bae21b198868d4052c075610308c
https://doi.org/10.1182/blood-2008-04-151043
https://doi.org/10.1182/blood-2008-04-151043
Publikováno v:
Infection and Immunity, 70(3), 1319-1325
Infection and Immunity 70 (2002) 3
Infection and Immunity 70 (2002) 3
In the present study we investigated the role of the fibronectin (FN)- and fibrinogen (FGN)-binding protein (FBPS) in the pathogenesis of Streptococcus suis serotype 2 in piglets. The complete gene encoding FBPS from S. suis serotype 2 was cloned in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ccafd531cdb9a6188b268bce6a28c2
https://doi.org/10.1128/iai.70.3.1319-1325.2002
https://doi.org/10.1128/iai.70.3.1319-1325.2002
Autor:
John G.J.M. Bol, Robin Verhaar, Benjamin Drukarch, Cornelis A.M. Jongenelen, Micha M.M. Wilhelmus
Publikováno v:
Neurochemistry International, 62(4), 486-491. Elsevier Limited
Verhaar, R, Drukarch, B, Bol, J G J M, Jongenelen, C A M & Wilhelmus, M M M 2013, ' Tissue transglutaminase cross-links beclin 1 and regulates autophagy in MPP+-treated human SH-SY5Y cells ', Neurochemistry International, vol. 62, no. 4, pp. 486-491 . https://doi.org/10.1016/j.neuint.2013.01.024
Verhaar, R, Drukarch, B, Bol, J G J M, Jongenelen, C A M & Wilhelmus, M M M 2013, ' Tissue transglutaminase cross-links beclin 1 and regulates autophagy in MPP+-treated human SH-SY5Y cells ', Neurochemistry International, vol. 62, no. 4, pp. 486-491 . https://doi.org/10.1016/j.neuint.2013.01.024
Tissue transglutaminase (tTG) is a cross-linking enzyme involved in protein aggregation during Parkinson's disease (PD) pathogenesis. Autophagy is inhibited by tTG activation via a mechanism in which cross-linking of beclin 1, an autophagy initiator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fd3577c4788f525bb2374aaa00c242
https://research.vumc.nl/en/publications/a7f62d0e-3ee6-41c8-b5f3-6251eb71a782
https://research.vumc.nl/en/publications/a7f62d0e-3ee6-41c8-b5f3-6251eb71a782
Autor:
Anne-Marie van Dam, Robin Verhaar, Melanie Gérard, Micha M.M. Wilhelmus, Veerle Baekelandt, Cornelis A.M. Jongenelen, Benjamin Drukarch
Publikováno v:
Neurochemistry International, 58(7), 785-793. Elsevier Limited
Verhaar, R, Jongenelen, C A M, Gerard, M, Baekelandt, V, Van Dam, A-M, Wilhelmus, M M M & Drukarch, B 2011, ' Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease ', Neurochemistry International, vol. 58, no. 7, pp. 785-793 . https://doi.org/10.1016/j.neuint.2011.03.004
Verhaar, R, Jongenelen, C A M, Gerard, M, Baekelandt, V, Van Dam, A-M, Wilhelmus, M M M & Drukarch, B 2011, ' Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease ', Neurochemistry International, vol. 58, no. 7, pp. 785-793 . https://doi.org/10.1016/j.neuint.2011.03.004
Transamidation of α-synuclein by the Ca(2+)-dependent enzyme tissue transglutaminase (tTG, EC 2.3.2.13) is implicated in Parkinson's disease (PD). tTG may therefore offer a novel therapeutic target to intervene in PD. Here we first evaluated the pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc908c73228d09c6d213814642b5015
https://research.vumc.nl/en/publications/9feb5088-2790-4d71-8db5-2477c4e36df0
https://research.vumc.nl/en/publications/9feb5088-2790-4d71-8db5-2477c4e36df0
Autor:
Annemieke J.M. Rozemuller, Robin Verhaar, Anne-Marie van Dam, John G.J.M. Bol, Jeroen J.M. Hoozemans, Benjamin Drukarch, Micha M.M. Wilhelmus
Publikováno v:
Wilhelmus, M M M, Verhaar, R, Bol, J G J M, van Dam, A-M, Hoozemans, J J M, Rozemuller, A J M & Drukarch, B 2011, ' Novel role of transglutaminase 1 in corpora amylacea formation? ', Neurobiology of Aging, vol. 32, no. 5, pp. 845-856 . https://doi.org/10.1016/j.neurobiolaging.2009.04.019
Neurobiology of Aging, 32(5), 845-856. Elsevier Inc.
Neurobiology of Aging, 32(5), 845-856. Elsevier Inc.
Corpora amylacea (CA) are both age and neurodegeneration-related spherical bodies, consisting of polymerized proteins, often thought to be involved in sequestration of hazardous products of cellular metabolism in brain. Although CA formation is assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7e1f1b57c257094e04aeaa5f354d88
https://research.vumc.nl/en/publications/614aebef-57d7-405b-af71-8079dff209ba
https://research.vumc.nl/en/publications/614aebef-57d7-405b-af71-8079dff209ba
Autor:
Micha M M, Wilhelmus, Robin, Verhaar, Gerda, Andringa, John G J M, Bol, Patrick, Cras, Ling, Shan, Jeroen J M, Hoozemans, Benjamin, Drukarch
Publikováno v:
Brain Pathol
Parkinson's disease (PD) is characterized by the accumulation of α‐synuclein aggregates and degeneration of melanized neurons. The tissue transglutaminase (tTG) enzyme catalyzes molecular protein cross‐linking. In PD brain, tTG‐induced cross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::859d9b0b6bc451a4714cf5d173b6ca34
https://pubmed.ncbi.nlm.nih.gov/20731657
https://pubmed.ncbi.nlm.nih.gov/20731657
Publikováno v:
Transfusion, 45(1), 82-89. Wiley-Blackwell
BACKGROUND: Deterioration of platelet (PLT) quality during storage is accompanied by an increase in lactate production, indicating a decrease in mitochondrial function. In this study, the optimal conditions under which the fluorescent dye JC-1 can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf95a63ce2521d4b2f38a366850baadd
https://pubmed.ncbi.nlm.nih.gov/15647022
https://pubmed.ncbi.nlm.nih.gov/15647022
Autor:
C. W. N. Gouwerok, Nicolaas J.H. Raat, Arthur J. Verhoeven, Robin Verhaar, Egbert G. Mik, Dirk de Korte, Can Ince, Peter Goedhart
Publikováno v:
Critical care medicine, 33(1), 39-45. Lippincott Williams and Wilkins
OBJECTIVE To determine whether the storage time of human leukodepleted red blood cell concentrates compromises intestinal microvascular oxygen concentration oxygen (muPo(2)) during isovolemic exchange transfusion at low hematocrit. DESIGN Prospective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7eb84623b5b6e2b7ed47e90aca5cbd0
https://pubmed.ncbi.nlm.nih.gov/15644680
https://pubmed.ncbi.nlm.nih.gov/15644680