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Does lung function change in the months after an asthma exacerbation in children?

Autor: Françoise Vermeulen, Stephen Turner, Joanne Martin, Anne B. Chang, Marielle W. Pijnenburg, Helen L. Petsky, Graham Roberts, Stanley J. Szefler, Peter J. Gergen, Katharine C. Pike, Robin Vael

Publikováno v: Pediatric allergy and immunology
Pediatric Allergy and Immunology, 32(6), 1208-1216. Blackwell Publishing

Background: There are limited data describing lung function changes in children after an asthma exacerbation. Our hypothesis was that lung function does not fully recover in children in the months following an asthma exacerbation. Methods: We used a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98853dea3270cc8a84cf1cf5ce175ae2
https://doi.org/10.1111/pai.13503

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What is a clinically meaningful change in exhaled nitric oxide for children with asthma?

Autor: Shona Fielding, Françoise Vermeulen, Steve Turner, Johan C. de Jongste, Katherine Pike, Peter J. Gergen, Thomas Frischer, Robin Vael, Graham Roberts, Maria Fritsch, Stanley J. Szefler, Mariëlle W. Pijnenburg, Anne B. Chang, Helen L. Petsky

Publikováno v: Pediatric Pulmonology, 55(3), 599-606. Wiley-Liss Inc.
Pediatric pulmonology

Introduction: Fractional exhaled nitric oxide (F ENO) may be a useful objective measurement to guide asthma treatment. What remains uncertain is what change in F ENO is clinically significant. Methods: An individual patient data analysis was performe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e43fa0128f94ed41663e906c0040f5
https://pure.eur.nl/en/publications/490cf289-ecca-44e9-a586-ac4a48f29979

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By how much can exhaled nitric oxide vary over three months in children with stable asthma?

Autor: Helen L. Petsky, Shona Fielding, Graham Roberts, Stanley J. Szefler, Anne B. Chang, Stephen Turner, Peter J. Gergen, Maria Fritsch, Robin Vael, Françoise Vermeulen, Katy Pike, Marielle W. Pijnenburg, Johan C. de Jongste, Thomas Frischer

Publikováno v: Paediatric asthma and allergy.

Introduction: Repeated measurements of fractional exhaled nitric oxide (FeNO) may be useful objective measurements in the management of asthma. There is uncertainty in what merits a clinically-relevant change in FeNO. Methods: Individual participant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88ea19a0703f57076ef60d62dc38d961
https://doi.org/10.1183/13993003.congress-2019.pa5419

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Does treatment guided by exhaled nitric oxide fraction improve outcomes in subgroups of children with asthma?

Autor: Katherine Pike, Peter J. Gergen, Mariëlle W. Pijnenburg, Johan C. de Jongste, Helen L. Petsky, Françoise Vermeulen, Shona S. Fielding, Maria Fritsch, Thomas Frischer, Robin Vael, Steve S. Turner, Graham Roberts, Stanley J. Szefler, Anne B. Chang

Publikováno v: The European respiratory journal, 55(5). European Respiratory Society
The European respiratory journal

IntroductionExhaled nitric oxide fraction (FENO), a biomarker of eosinophilic airway inflammation, may be useful to guide asthma treatment. FENO-guided treatment may be more effective in certain subgroups for improving asthma outcomes compared to sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0b2ce4057ecb5766eeac2cbd58fdfb
https://doi.org/10.1183/13993003.01879-2019

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Change in FEV(1) and Feno Measurements as Predictors of Future Asthma Outcomes in Children

Autor: Mariëlle W. Pijnenburg, Thomas Frischer, Shona Fielding, Helen L. Petsky, Steve Turner, Johan C. de Jongste, Françoise Vermeulen, Graham Roberts, Stanley J. Szefler, Katharine C. Pike, Robin Vael, Anne A.B. Chang, Maria Fritsch, Peter J. Gergen

Publikováno v: Chest
Chest, 155(2), 331-341. American College of Chest Physicians

Background: repeated measurements of spirometry and fractional exhaled nitric oxide (FeNO) are recommended as part of the management of childhood asthma, but the evidence base for such recommendations is small. We tested the hypothesis that reducing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f03c8953f90cb8c7fbc059f5589603
https://europepmc.org/articles/PMC6688975/

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Do changes in spirometric indices and FeNO predict asthma outcomes in children? An individual patient data analysis using results from seven FeNO trials

Autor: Stan Szefler, Thomas Frischer, Helen L. Petsky, Shona Fielding, Katy Pike, Maria Fritsch, Françoise Vermeulen, Johan C. de Jongste, Stephen Turner, Robin Vael, Peter J. Gergen, Anne B. Chang, Marielle W. Pijnenburg, Graham Roberts

Publikováno v: Paediatric respiratory epidemiology.

Introduction: Guidelines recommend spirometry and/or fractional exhaled nitric oxide (FeNO) as objective measurements to guide asthma management. Our hypothesis was that falling FEV1, FEV1/FVC ratio or FEF25-75 or rising FeNO measurements are associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cab435fbb167f0a17523ad8a52691731
https://doi.org/10.1183/13993003.congress-2018.pa5011

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Response

Autor: Mariëlle W. Pijnenburg, Maria Fritsch, Shona Fielding, Johan C. de Jongste, Thomas Frischer, Françoise Vermeulen, Graham Roberts, Katharine C. Pike, Stanley J. Szefler, Steve Turner, Helen L. Petsky, Robin Vael, Peter J. Gergen, Anne B. Chang

Publikováno v: Chest. 155:1313-1314

To the Editor: We thank Drs Yawn and Kaplan for their interest and comments on our article in which we describe a secondary analysis of data from seven published trials where fractional exhaled nitric oxide (Feno) was used to guide asthma treatment i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67eb2eb995aa9043cd47cceed185882
https://doi.org/10.1016/j.chest.2019.03.016

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S58 Fev1 and feno as predictors of asthma outcomes in children? an individual patient data analysis using data from six feno trials

Autor: Shona Fielding, Maria Fritsch, Stan Szefler, Helen L. Petsky, Anne B. Chang, S Turner, Thomas Frischer, J. C. de Jongste, Peter J. Gergen, Katy Pike, Robin Vael, Françoise Vermeulen, Marielle W. Pijnenburg, Graham Roberts

Publikováno v: Paediatric asthma: big and real world data.

Introduction Some guidelines advocate using FEV1 and/or fractional exhaled nitric oxide (FeNO) in the management of childhood asthma, but evidence supporting these recommendations is generally unsupportive. Our hypothesis was that reduced FEV1 and/or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cb139c8c040ca1acf5f48e093cc2fc5
https://doi.org/10.1136/thoraxjnl-2017-210983.64

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By how much can exhaled nitric oxide vary without a change in clinical status?

Autor: Shona Fielding, Pike Katy, Robin Vael, Anne B. Chang, Thomas Frischer, Françoise Vermeulen, Maria Fritsch, Stephen Turner, Peter J. Gergen, Marielle W. Pijnenburg, Helen L. Petsky, Johan C. de Jongste, Graham Roberts, Stanley J. Szefler

Publikováno v: Paediatric Asthma and Allergy.

Background: Fractional exhaled nitric oxide (FeNO) may be a useful biomarker to guide asthma treatment. A study in children without asthma and with mild asthma suggested that FeNO may vary by up to 100% over 2 months. The aim of this study was to des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbcd4aaed51035ff71a8f68b9f67cd3d
https://doi.org/10.1183/1393003.congress-2017.pa4497

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