Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Robin Temming"'
Autor:
Thorunn A. Olafsdottir, Gudmar Thorleifsson, Aitzkoa Lopez de Lapuente Portilla, Stefan Jonsson, Lilja Stefansdottir, Abhishek Niroula, Aslaug Jonasdottir, Hannes P. Eggertsson, Gisli H. Halldorsson, Gudny E. Thorlacius, Asgeir O. Arnthorsson, Unnur S. Bjornsdottir, Folkert W. Asselbergs, Arthur E. H. Bentlage, Gudmundur I. Eyjolfsson, Steinunn Gudmundsdottir, Kristbjorg Gunnarsdottir, Bjarni V. Halldorsson, Hilma Holm, Bjorn R. Ludviksson, Pall Melsted, Gudmundur L. Norddahl, Isleifur Olafsson, Saedis Saevarsdottir, Olof Sigurdardottir, Asgeir Sigurdsson, Robin Temming, Pall T. Önundarson, Unnur Thorsteinsdottir, Gestur Vidarsson, Patrick Sulem, Daniel F. Gudbjartsson, Ingileif Jonsdottir, Björn Nilsson, Kari Stefansson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association
Externí odkaz:
https://doaj.org/article/355943621ae84500945b3eafee4e0e12
Autor:
Zoltán Szittner, Arthur E. H. Bentlage, A. Robin Temming, David E. Schmidt, Remco Visser, Suzanne Lissenberg-Thunnissen, Juk Yee Mok, Wim J. E. van Esch, Myrthe E. Sonneveld, Erik L. de Graaf, Manfred Wuhrer, Leendert Porcelijn, Masja de Haas, C. Ellen van der Schoot, Gestur Vidarsson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate. However, the disease manifests itself in only a fraction of pregnancies, mo
Externí odkaz:
https://doaj.org/article/91e5bf2c71b7454b8cb27f5857ceb701
Autor:
Cristina Di Carluccio, Pablo Soriano-Maldonado, Francesca Berni, Carla J. C. de Haas, A. Robin Temming, Astrid Hendriks, Sara Ali, Antonio Molinaro, Alba Silipo, Nina M. van Sorge, Mark J. van Raaij, Jeroen D. C. Codee, Roberta Marchetti
Publikováno v:
ACS central science, 8(10), 1383-1392. American Chemical Society
ACS Central Science, 8(10), 1383-1392. AMER CHEMICAL SOC
ACS Central Science, 8(10), 1383-1392. AMER CHEMICAL SOC
Wall teichoic acids (WTAs) are glycopolymers decorating the surface of Gram-positive bacteria and potential targets for antibody-mediated treatments against Staphylococcus aureus, including methicillin-resistant (MRSA) strains. Through a combination
Autor:
A. Robin Temming, Matthias Tammes Buirs, Arthur E. H. Bentlage, Louise W. Treffers, Hannah Feringa, Steven W. de Taeye, Taco W. Kuijpers, Sietse Q. Nagelkerke, Giso Brasser, Juk Yee Mok, Wim J. E. van Esch, Timo K. van den Berg, Theo Rispens, C. Ellen van der Schoot, Gestur Vidarsson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Antibody-mediated blood disorders ensue after auto- or alloimmunization against blood cell antigens, resulting in cytopenia. Although the mechanisms of cell destruction are the same as in immunotherapies targeting tumor cells, many factors are still
Externí odkaz:
https://doaj.org/article/a051437a3dee48c7afce6b02bcb366cb
Autor:
Marieke H. Heineke, Paula J. Winter, Niels Heemskerk, Suzanne N. Lissenberg-Thunnissen, Marco de Donatis, Dennis Y. Gout, A. Robin Temming, Cornelis W. Tuk, Thies Rösner, Marijn Bögels, Tessa Hellingman, Mandy Gruijs, Marjolein van Egmond, Jantine E. Bakema, Arthur E. H. Bentlage, Gestur Vidarsson, Thomas Valerius
Publikováno v:
Journal of Clinical Investigation, 131(6), 1. The American Society for Clinical Investigation
J Clin Invest
Heemskerk, N, Gruijs, M, Temming, A R, Heineke, M H, Gout, D Y, Hellingman, T, Tuk, C W, Winter, P J, Lissenberg-Thunnissen, S, Bentlage, A E, de Donatis, M, Bögels, M, Rösner, T, Valerius, T, Bakema, J E, Vidarsson, G & van Egmond, M 2021, ' Augmented antibody-based anticancer therapeutics boost neutrophil cytotoxicity ', Journal of Clinical Investigation, vol. 131, no. 6, e134680 . https://doi.org/10.1172/JCI134680
Journal of Clinical Investigation, 131(6):e134680. The American Society for Clinical Investigation
Journal of clinical investigation, 131(6):e134680. The American Society for Clinical Investigation
J Clin Invest
Heemskerk, N, Gruijs, M, Temming, A R, Heineke, M H, Gout, D Y, Hellingman, T, Tuk, C W, Winter, P J, Lissenberg-Thunnissen, S, Bentlage, A E, de Donatis, M, Bögels, M, Rösner, T, Valerius, T, Bakema, J E, Vidarsson, G & van Egmond, M 2021, ' Augmented antibody-based anticancer therapeutics boost neutrophil cytotoxicity ', Journal of Clinical Investigation, vol. 131, no. 6, e134680 . https://doi.org/10.1172/JCI134680
Journal of Clinical Investigation, 131(6):e134680. The American Society for Clinical Investigation
Journal of clinical investigation, 131(6):e134680. The American Society for Clinical Investigation
Most clinically used anticancer mAbs are of the IgG isotype, which can eliminate tumor cells through NK cell-mediated antibody-dependent cellular cytotoxicity and macrophage-mediated antibody-dependent phagocytosis. IgG, however, ineffectively recrui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253c7d45fb6c5b38d74a0986dbf8bca1
https://dspace.library.uu.nl/handle/1874/425229
https://dspace.library.uu.nl/handle/1874/425229
Autor:
Wim J E van Esch, Juk Yee Mok, Ruben G J Douwes, Theo Rispens, Giso Brasser, Peter C. Ligthart, Hans de Haard, Matthias Tammes Buirs, Gestur Vidarsson, Arthur E. H. Bentlage, Steven W. de Taeye, Maximilian Brinkhaus, Jorrit Gerritsen, Peter Verheesen, A. Robin Temming
Publikováno v:
Journal of immunology (Baltimore, Md., 205(12), 3456-3467. American Association of Immunologists
Abs of the IgG isotype mediate effector functions like Ab-dependent cellular cytotoxicity and Ab-dependent cellular phagocytosis by Fc interactions with FcγRs and complement-dependent cytotoxicity upon IgG-Fc binding to C1q. In this study, we descri
Autor:
Gillian Dekkers, Sietse Q. Nagelkerke, James C. Zimring, Peter C. Ligthart, Louise A. de Neef, Manfred Wuhrer, Jana Koers, Christine W. Bruggeman, Erik L. de Graaf, Theo Rispens, Taco W. Kuijpers, Gestur Vidarsson, A. Robin Temming, Steven W. de Taeye
Publikováno v:
Journal of Immunology, 203(12), 3126-3135
Journal of immunology (Baltimore, Md., 203(12), 3126-3135. American Association of Immunologists
Journal of immunology (Baltimore, Md., 203(12), 3126-3135. American Association of Immunologists
Ab-dependent cellular cytotoxicity (ADCC) is one of the most important effector mechanisms of tumor-targeting Abs in current immunotherapies. In ADCC and other Ab-dependent activation of myeloid effector cells, close cell–cell contact (between effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8530629ee5fb74a4d4b1897ff701ba8b
http://hdl.handle.net/1887/121321
http://hdl.handle.net/1887/121321
Autor:
A. Robin Temming, Gillian Dekkers, Zoltan Szittner, Arthur E. H. Bentlage, Manfred Wuhrer, Fleur S. van de Bovenkamp, Gestur Vidarsson, Theo Rispens, H. Rosina Plomp, Ninotska I. L. Derksen
Publikováno v:
Scientific Reports
Scientific reports, 9(1):9995. Nature Publishing Group
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific reports, 9(1):9995. Nature Publishing Group
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
The precise mechanisms underlying anti-inflammatory effects of intravenous immunoglobulin (IVIg) therapies remain elusive. The sialylated IgG fraction within IVIg has been shown to be therapeutically more active in mouse models. Functionally, it has
Autor:
Mariëlle J P Maas, C. Ellen van der Schoot, Maximilian Brinkhaus, Gestur Vidarsson, Wim J E van Esch, Juk Yee Mok, Arthur E. H. Bentlage, Steven W. de Taeye, A. Robin Temming, Lorna M. Williamson, Giso Brasser, Kathryn L. Armour, Mike Clark, Nigel M. Stapleton
Publikováno v:
Scientific reports, 9(1):7363. Nature Publishing Group
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8c490c504a73253465b55c5839610f
https://pure.amc.nl/en/publications/reduced-fcrnmediated-transcytosis-of-igg2-due-to-a-missing-glycine-in-its-lower-hinge(f84fbefd-a845-47a2-9e43-d541e9e077d0).html
https://pure.amc.nl/en/publications/reduced-fcrnmediated-transcytosis-of-igg2-due-to-a-missing-glycine-in-its-lower-hinge(f84fbefd-a845-47a2-9e43-d541e9e077d0).html
Autor:
A. Robin Temming, Gillian Dekkers, Ninotska I. L. Derksen, Fleur S. van de Bovenkamp, Theo Rispens, H. Rosina Plomp, Manfred Wuhrer, Gestur Vidarsson, Arthur E. H. Bentlage, Zoltan Szittner
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
The original version of this Article contained errors in the Reference list. Reference 26 was incorrectly listed as reference 48, and reference 27 was incorrectly listed as reference 31. As a result, the original references 26–30 are now listed as