Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Robin S Bon"'
Autor:
Christian Tiede, Robert Bedford, Sophie J Heseltine, Gina Smith, Imeshi Wijetunga, Rebecca Ross, Danah AlQallaf, Ashley PE Roberts, Alexander Balls, Alistair Curd, Ruth E Hughes, Heather Martin, Sarah R Needham, Laura C Zanetti-Domingues, Yashar Sadigh, Thomas P Peacock, Anna A Tang, Naomi Gibson, Hannah Kyle, Geoffrey W Platt, Nicola Ingram, Thomas Taylor, Louise P Coletta, Iain Manfield, Margaret Knowles, Sandra Bell, Filomena Esteves, Azhar Maqbool, Raj K Prasad, Mark Drinkhill, Robin S Bon, Vikesh Patel, Sarah A Goodchild, Marisa Martin-Fernandez, Ray J Owens, Joanne E Nettleship, Michael E Webb, Michael Harrison, Jonathan D Lippiat, Sreenivasan Ponnambalam, Michelle Peckham, Alastair Smith, Paul Ko Ferrigno, Matt Johnson, Michael J McPherson, Darren Charles Tomlinson
Publikováno v:
eLife, Vol 6 (2017)
Molecular recognition reagents are key tools for understanding biological processes and are used universally by scientists to study protein expression, localisation and interactions. Antibodies remain the most widely used of such reagents and many sh
Externí odkaz:
https://doaj.org/article/703d31dbc0f14e0190b7ae2c2e80be55
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115672- (2023)
In intestinal smooth muscle cells, receptor-operated TRPC4 are responsible for the majority of muscarinic receptor cation current (mICAT), which initiates cholinergic excitation-contraction coupling. Our aim was to examine the effects of the TRPC4 in
Externí odkaz:
https://doaj.org/article/96d674eac48e42afbf777a4d68942345
Autor:
Eulashini Chuntharpursat-Bon, Oleksandr V. Povstyan, Melanie J. Ludlow, David J. Carrier, Marjolaine Debant, Jian Shi, Hannah J. Gaunt, Claudia C. Bauer, Alistair Curd, T. Simon Futers, Paul D. Baxter, Michelle Peckham, Stephen P. Muench, Antony Adamson, Neil Humphreys, Sarka Tumova, Robin S. Bon, Richard Cubbon, Laeticia Lichtenstein, David J. Beech
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
The PIEZO1 channel and the PECAM1 cell adhesion molecule interact and PIEZO1 cooperates with PECAM1 and CDH5 cell junctions during mechanical stress.
Externí odkaz:
https://doaj.org/article/ec77feaa25314fbeac8b7a91697307ac
Autor:
Faye L. Styles, Moza M. Al-Owais, Jason L. Scragg, Eulashini Chuntharpursat-Bon, Nishani T. Hettiarachchi, Jonathan D. Lippiat, Aisling Minard, Robin S. Bon, Karen Porter, Piruthivi Sukumar, Chris Peers, Lee D. Roberts
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract Cellular energy metabolism is fundamental for all biological functions. Cellular proliferation requires extensive metabolic reprogramming and has a high energy demand. The Kv1.3 voltage-gated potassium channel drives cellular proliferation.
Externí odkaz:
https://doaj.org/article/de761f22f16e420bb481b26f474f0f11
Autor:
David J. Wright, Katie J. Simmons, Rachel M. Johnson, David J. Beech, Stephen P. Muench, Robin S. Bon
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Wright et al. report the first structure of a human TRPC1/4/5 channel in complex with a xanthine-based TRPC5 inhibitor Pico145. They find that Pico145 binds to a conserved lipid binding site of TRPC5, where it displaces a phospholipid. This study pro
Externí odkaz:
https://doaj.org/article/a4fe404129504c4c9fa1e7487c3b639e
Autor:
David P. Klebl, Matthew C. Feasey, Emma L. Hesketh, Neil A. Ranson, Heiko Wurdak, Frank Sobott, Robin S. Bon, Stephen P. Muench
Publikováno v:
iScience, Vol 24, Iss 1, Pp 102022- (2021)
Summary: Chaperonins play an important role in folding newly synthesized or translocated proteins in all organisms. The bacterial chaperonin GroEL has served as a model system for the understanding of these proteins. In comparison, its human homolog,
Externí odkaz:
https://doaj.org/article/e8e70ed735e24c10868a4546f1eca23f
Autor:
Jacob R. Hauser, Hester A. Beard, Mary E. Bayana, Katherine E. Jolley, Stuart L. Warriner, Robin S. Bon
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2019-2025 (2016)
2-Cyanobenzothiazoles (CBTs) are useful building blocks for: 1) luciferin derivatives for bioluminescent imaging; and 2) handles for bioorthogonal ligations. A particularly versatile CBT is 6-amino-2-cyanobenzothiazole (ACBT), which has an amine hand
Externí odkaz:
https://doaj.org/article/4dec427fbe5d4b99afdcb709f5fe3d60
Publikováno v:
Sensing and Bio-Sensing Research, Vol 6, Iss , Pp 1-6 (2015)
The emergence of stratified and personalised medicine and the associated need for highly multiplexed detection strategies are driving the development of innovative sensor technology. Electronic immunosensor arrays capable of label-free and highly par
Externí odkaz:
https://doaj.org/article/df4f5d35123245ee837b5c3e7ab3155b
Autor:
Sophie Lepannetier, Roberta Gualdani, Sabrina Tempesta, Olivier Schakman, François Seghers, Anna Kreis, Xavier Yerna, Amina Slimi, Marie de Clippele, Nicolas Tajeddine, Thomas Voets, Robin S. Bon, David J. Beech, Fadel Tissir, Philippe Gailly
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Group I metabotropic glutamate receptors, in particular mGluR5, have been implicated in various forms of synaptic plasticity that are believed to underlie declarative memory. We observed that mGluR5 specifically activated a channel containing TRPC1,
Externí odkaz:
https://doaj.org/article/b2b123bfce2440ceab2609b56652b5b8
Autor:
Yin‐Ying Mak, Bi‐Juin Loong, Paul Millns, Claudia C. Bauer, Robin S. Bon, Yvonne Mbaki, Fong‐Kai Lee, Kuan‐Hon Lim, Cin Kong, Sue‐Mian Then, Kang‐Nee Ting
Publikováno v:
Phytotherapy research : PTR. 36(7)
This study investigated the vasorelaxant effects of schwarzinicine A, an alkaloid recently reported from Ficus schwarzii Koord. Regulation of calcium homeostasis in vascular smooth muscle cells (VSMC) is viewed as one of the main mechanisms for contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ed46aab9817f843c304579925473b8
https://pubmed.ncbi.nlm.nih.gov/35537691
https://pubmed.ncbi.nlm.nih.gov/35537691