Zobrazeno 1 - 10 of 104 pro vyhledávání: '"Robin R. Hodges"'
1
Akademický článek
Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca2+ and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases
Autor: Anne V. Lyngstadaas, Markus V. Olsen, Jeffrey A. Bair, Robin R. Hodges, Tor P. Utheim, Charles N. Serhan, Darlene A. Dartt
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
The amount of mucin secreted by conjunctival goblet cells is regulated to ensure the optimal level for protection of the ocular surface. Under physiological conditions lipid specialized pro-resolving mediators (SPM) are essential for maintaining tiss
Externí odkaz: https://doaj.org/article/b96e0ffaf4194d2ba21cc43ae435c0cd
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2
Akademický článek
Context-Dependent Regulation of Conjunctival Goblet Cell Function by Allergic Mediators
Autor: Laura García-Posadas, Robin R. Hodges, Yolanda Diebold, Darlene A. Dartt
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract In the eye, goblet cells responsible for secreting mucins are found in the conjunctiva. When mucin production is not tightly regulated several ocular surface disorders may occur. In this study, the effect of the T helper (Th) 2-type cytokine
Externí odkaz: https://doaj.org/article/0cf80d37144944938217eb5a2176f34d
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4
Resolvin E1 Reduces Leukotriene B4–Induced Intracellular Calcium Increase and Mucin Secretion in Rat Conjunctival Goblet Cells
Autor: Charles N. Serhan, Menglu Yang, Jeffrey Bair, Robin R. Hodges, Darlene A. Dartt
Publikováno v: Am J Pathol
Leukotriene B4 (LTB4) is a major proinflammatory mediator important in host defense, whereas resolvins (Rvs) are produced during the resolution phase of inflammation. The authors determined the actions of both RvE1 and RvD1 on LTB4–induced response
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea8f6f9b10268ce54591d32df8a047f
https://doi.org/10.1016/j.ajpath.2020.06.001
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5
Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca 2+ ] and secretion in conjunctival goblet cells
Autor: Charles N. Serhan, Robin R. Hodges, Anne V. Lyngstadaas, Darlene A. Dartt, Tor Paaske Utheim, Markus V. Olsen, Jeffrey Bair
Publikováno v: Journal of Cellular Physiology. 236:340-353
Mucin secretion from conjunctival goblet cells forms the tear film mucin layer and requires regulation to function properly. Maresin 1 (MaR1) is a specialized proresolving mediator produced during the resolution of inflammation. We determined if MaR1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83d214314d7a583a148a62c44f0c4269
https://doi.org/10.1002/jcp.29846
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6
Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells
Autor: Charles N. Serhan, Marit Lippestad, Darlene A. Dartt, Dayu Li, Robin R. Hodges, Tor Paaske Utheim, Rebecca Kaye, Nora Botten
Publikováno v: Experimental Eye Research. 180:53-62
PURPOSE: To identify interactions of the epidermal growth factor receptor (EGFR) with the pro-resolving mediator receptors for RvD1 and RvE1 to stimulate an increase in intracellular [Ca(2+)] ([Ca(2+)](i)) and mucin secretion from cultured human and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047f540a766ffa9c01bd428e018e2e22
https://doi.org/10.1016/j.exer.2018.11.018
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7
Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model
Autor: Darlene A. Dartt, Chen Yu, William Swift, Daniel R. Saban, Robin R. Hodges, Charles N. Serhan, Rose Mathew, Nora Botten, Nancy J. Reyes, Rebecca Kaye
Publikováno v: Mucosal immunology
Severe, chronic eye allergy is an understudied, vision-threatening condition. Treatments remain limited. We used a mouse model of severe allergic eye disease (AED) to determine whether topical application of the pro-resolution mediator Resolvin D1 (R
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff4fa67262ef8cbd4749d98b873fe43
https://doi.org/10.1038/s41385-018-0089-1
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10
Akademický článek
Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells.
Autor: Victoria E McGilligan, Meredith S Gregory-Ksander, Dayu Li, Jonathan E Moore, Robin R Hodges, Michael S Gilmore, Tara C B Moore, Darlene A Dartt
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74010 (2013)
The conjunctiva is a moist mucosal membrane that is constantly exposed to an array of potential pathogens and triggers of inflammation. The NACHT, leucine rich repeat (LRR), and pyrin domain-containing protein 3 (NLRP3) is a Nod-like receptor that ca
Externí odkaz: https://doaj.org/article/86c2d0c103c24a71bed12027865fe906
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