Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Robin R Ali"'
Autor:
Anastasios Georgiadis, Marion Tschernutter, James W B Bainbridge, Kamaljit S Balaggan, Freya Mowat, Emma L West, Peter M G Munro, Adrian J Thrasher, Karl Matter, Maria S Balda, Robin R Ali
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0295782 (2023)
[This corrects the article DOI: 10.1371/journal.pone.0015730.].
Externí odkaz:
https://doaj.org/article/a61a5b69821d4c4198e2f27c773c2a28
Autor:
Matthew J Annear, Freya M Mowat, Laurence M Occelli, Alexander J Smith, Paul G Curran, James W Bainbridge, Robin R Ali, Simon M Petersen-Jones
Publikováno v:
Cells, Vol 10, Iss 1, p 115 (2021)
The Rpe65-deficient dog has been important for development of translational therapies of Leber congenital amaurosis type 2 (LCA2). The purpose of this study was to provide a comprehensive report of the natural history of retinal changes in this dog m
Externí odkaz:
https://doaj.org/article/b36e0224fa07489ab67cca4e8c42f2e6
Autor:
Pilar Villacampa, Katja E Menger, Laura Abelleira, Joana Ribeiro, Yanai Duran, Alexander J Smith, Robin R Ali, Ulrich F Luhmann, James W B Bainbridge
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179759 (2017)
Retinal ischemia and pathological angiogenesis cause severe impairment of sight. Oxygen-induced retinopathy (OIR) in young mice is widely used as a model to investigate the underlying pathological mechanisms and develop therapeutic interventions. We
Externí odkaz:
https://doaj.org/article/f05d364bb4304162a5572ab0949cbfda
Autor:
Claire Hippert, Anna B Graca, Amanda C Barber, Emma L West, Alexander J Smith, Robin R Ali, Rachael A Pearson
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120415 (2015)
Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells. It is typically assumed that ph
Externí odkaz:
https://doaj.org/article/846fedb3d31e4aa59f20d7769288772b
Autor:
Colin J Chu, Philipp Herrmann, Livia S Carvalho, Sidath E Liyanage, James W B Bainbridge, Robin R Ali, Andrew D Dick, Ulrich F O Luhmann
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63002 (2013)
Despite advances in clinical imaging and grading our understanding of retinal immune responses and their morphological correlates in experimental autoimmune uveoretinitis (EAU), has been hindered by the requirement for post-mortem histology. To date,
Externí odkaz:
https://doaj.org/article/963d4aa2a71f46a690fe754e0b54e13b
Autor:
Mei Hong Tan, Donna S Mackay, Jill Cowing, Hoai Viet Tran, Alexander J Smith, Genevieve A Wright, Arundhati Dev-Borman, Robert H Henderson, Phillip Moradi, Isabelle Russell-Eggitt, Robert E MacLaren, Anthony G Robson, Michael E Cheetham, Dorothy A Thompson, Andrew R Webster, Michel Michaelides, Robin R Ali, Anthony T Moore
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32330 (2012)
Leber Congenital Amaurosis (LCA) and Early Childhood Onset Severe Retinal Dystrophy are clinically and genetically heterogeneous retinal disorders characterised by visual impairment and nystagmus from birth or early infancy. We investigated the preva
Externí odkaz:
https://doaj.org/article/ab358eecd7e74aa495b458512900acef
Autor:
Ulrich F O Luhmann, Clemens A Lange, Scott Robbie, Peter M G Munro, Jill A Cowing, Hannah E J Armer, Vy Luong, Livia S Carvalho, Robert E MacLaren, Frederick W Fitzke, James W B Bainbridge, Robin R Ali
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35551 (2012)
Microglia and macrophages are recruited to sites of retinal degeneration where local cytokines and chemokines determine protective or neurotoxic microglia responses. Defining the role of Ccl2-Ccr2 and Cx3cl1-Cx3cr1 signalling for retinal pathology is
Externí odkaz:
https://doaj.org/article/bfc789ae44094609887abe73bdbed687
Autor:
Prateek K Buch, Marija Mihelec, Phillippa Cottrill, Susan E Wilkie, Rachael A Pearson, Yanai Duran, Emma L West, Michel Michaelides, Robin R Ali, David M Hunt
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18089 (2011)
Cone dystrophy 3 (COD3) is a severe dominantly inherited retinal degeneration caused by missense mutations in GUCA1A, the gene encoding Guanylate Cyclase Activating Protein 1 (GCAP1). The role of GCAP1 in controlling cyclic nucleotide levels in photo
Externí odkaz:
https://doaj.org/article/3658d5bde1d24913974288c86057c43f
Autor:
Anastasios Georgiadis, Marion Tschernutter, James W B Bainbridge, Kamaljit S Balaggan, Freya Mowat, Emma L West, Peter M G Munro, Adrian J Thrasher, Karl Matter, Maria S Balda, Robin R Ali
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15730 (2010)
Cell-cell adhesion regulates the development and function of epithelia by providing mechanical support and by guiding cell proliferation and differentiation. The tight junction (TJ) protein zonula occludens (ZO)-1 regulates cell proliferation and gen
Externí odkaz:
https://doaj.org/article/ed7db6a99f1a47a485feca3e3b103677
Autor:
Wendy M Aartsen, Koen W R van Cleef, Lucie P Pellissier, Robert M Hoek, Rogier M Vos, Bas Blits, Erich M E Ehlert, Kamaljit S Balaggan, Robin R Ali, Joost Verhaagen, Jan Wijnholds
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12387 (2010)
BackgroundMüller cell gliosis occurs in various retinal pathologies regardless of the underlying cellular defect. Because activated Müller glial cells span the entire retina and align areas of injury, they are ideal targets for therapeutic strategi
Externí odkaz:
https://doaj.org/article/fbe4eb2ddd3748f092d1484bcd58d2f2