Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Robin R, Ali"'
Autor:
Robert Atkinson, Maria Georgiou, Chunbo Yang, Katarzyna Szymanska, Albert Lahat, Elton J. R. Vasconcelos, Yanlong Ji, Marina Moya Molina, Joseph Collin, Rachel Queen, Birthe Dorgau, Avril Watson, Marzena Kurzawa-Akanbi, Ross Laws, Abhijit Saxena, Chia Shyan Beh, Chileleko Siachisumo, Franziska Goertler, Magdalena Karwatka, Tracey Davey, Chris F. Inglehearn, Martin McKibbin, Reinhard Lührmann, David H. Steel, David J. Elliott, Lyle Armstrong, Henning Urlaub, Robin R. Ali, Sushma-Nagaraja Grellscheid, Colin A. Johnson, Sina Mozaffari-Jovin, Majlinda Lako
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity mechanism. We used pat
Externí odkaz:
https://doaj.org/article/543dcbabd0154436a3a7c83f1dd4c6bd
Autor:
Aikaterini A. Kalargyrou, Ayako Matsuyama, Emily P. Lanning, Mahmoud Khazim, Siobhan Guilfoyle, Alexander J. Smith, Robin R. Ali, Rachael A. Pearson
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102875- (2024)
Summary: Here, we present a protocol for isolating and culturing mouse photoreceptors in a minimal, chemically defined medium free from serum. We describe steps for retina dissection, enzymatic dissociation, photoreceptor enrichment, cell culture, ex
Externí odkaz:
https://doaj.org/article/2dc1158981f04ba4967d2e985553039f
Autor:
Maide Ö. Raeker, Nirosha D. Perera, Athanasios J. Karoukis, Lisheng Chen, Kecia L. Feathers, Robin R. Ali, Debra A. Thompson, Abigail T. Fahim
Publikováno v:
Cells, Vol 13, Iss 12, p 1068 (2024)
Choroideremia is an X-linked chorioretinal dystrophy caused by mutations in CHM, encoding Rab escort protein 1 (REP-1), leading to under-prenylation of Rab GTPases (Rabs). Despite ubiquitous expression of CHM, the phenotype is limited to degeneration
Externí odkaz:
https://doaj.org/article/46723e856b1640f98e5d3ac2dd01bda5
Autor:
Lisheng Chen, N. Dayanthi Perera, Athanasios J. Karoukis, Kecia L. Feathers, Robin R. Ali, Debra A. Thompson, Abigail T. Fahim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The retinal pigment epithelium (RPE) is a polarized monolayer that secretes growth factors and cytokines towards the retina apically and the choroid basolaterally. Numerous RPE secreted proteins have been linked to the pathogenesis of age-re
Externí odkaz:
https://doaj.org/article/6ff88f32799141fea6e94fdb2912f7c1
Autor:
Anastasios Georgiadis, Marion Tschernutter, James W B Bainbridge, Kamaljit S Balaggan, Freya Mowat, Emma L West, Peter M G Munro, Adrian J Thrasher, Karl Matter, Maria S Balda, Robin R Ali
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0295782 (2023)
[This corrects the article DOI: 10.1371/journal.pone.0015730.].
Externí odkaz:
https://doaj.org/article/a61a5b69821d4c4198e2f27c773c2a28
Autor:
Aikaterini A. Kalargyrou, Siobhan E. Guilfoyle, Alexander J. Smith, Robin R. Ali, Rachael A. Pearson
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
The retina encompasses a network of neurons, glia and epithelial and vascular endothelia cells, all coordinating visual function. Traditionally, molecular information exchange in this tissue was thought to be orchestrated by synapses and gap junction
Externí odkaz:
https://doaj.org/article/ff677c5a729c4075b5d3c4fd21a9accb
Autor:
Nozie D. Aghaizu, Katherine M. Warre-Cornish, Martha R. Robinson, Robin R. Ali, Rachael A. Pearson
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 101008- (2021)
Summary: The developing retina undergoes dynamic organizational changes involving significant intra-retinal motility of the encompassing cells. Here, we present a protocol for tracking retinal cell motility in live explanted mouse retinae. Although o
Externí odkaz:
https://doaj.org/article/bb1e36c346aa4d20989579bec184d5e1
Autor:
Joana Ribeiro, Christopher A. Procyk, Emma L. West, Michelle O’Hara-Wright, Monica F. Martins, Majid Moshtagh Khorasani, Aura Hare, Mark Basche, Milan Fernando, Debbie Goh, Neeraj Jumbo, Matteo Rizzi, Kate Powell, Menahil Tariq, Michel Michaelides, James W.B. Bainbridge, Alexander J. Smith, Rachael A. Pearson, Anai Gonzalez-Cordero, Robin R. Ali
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109022- (2021)
Summary: Age-related macular degeneration and other macular diseases result in the loss of light-sensing cone photoreceptors, causing irreversible sight impairment. Photoreceptor replacement may restore vision by transplanting healthy cells, which mu
Externí odkaz:
https://doaj.org/article/f2a1aa9c1fb544b5b5376bb03b90e605
Autor:
Adriana Buskin, Lili Zhu, Valeria Chichagova, Basudha Basu, Sina Mozaffari-Jovin, David Dolan, Alastair Droop, Joseph Collin, Revital Bronstein, Sudeep Mehrotra, Michael Farkas, Gerrit Hilgen, Kathryn White, Kuan-Ting Pan, Achim Treumann, Dean Hallam, Katarzyna Bialas, Git Chung, Carla Mellough, Yuchun Ding, Natalio Krasnogor, Stefan Przyborski, Simon Zwolinski, Jumana Al-Aama, Sameer Alharthi, Yaobo Xu, Gabrielle Wheway, Katarzyna Szymanska, Martin McKibbin, Chris F. Inglehearn, David J. Elliott, Susan Lindsay, Robin R. Ali, David H. Steel, Lyle Armstrong, Evelyne Sernagor, Henning Urlaub, Eric Pierce, Reinhard Lührmann, Sushma-Nagaraja Grellscheid, Colin A. Johnson, Majlinda Lako
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Mutations in pre-mRNA processing factors cause autosomal dominant retinitis pigmentosa. Here the authors provide insights into the pathophysiological mechanisms underlying non-syndromic retinal disease caused by heterozygous mutations in genes encodi
Externí odkaz:
https://doaj.org/article/39722a7de98941cab07e48fc0b8400de
Autor:
Patrick Ovando-Roche, Emma L. West, Matthew J. Branch, Robert D. Sampson, Milan Fernando, Peter Munro, Anastasios Georgiadis, Matteo Rizzi, Magdalena Kloc, Arifa Naeem, Joana Ribeiro, Alexander J. Smith, Anai Gonzalez-Cordero, Robin R. Ali
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract Background The use of human pluripotent stem cell-derived retinal cells for cell therapy strategies and disease modelling relies on the ability to obtain healthy and organised retinal tissue in sufficient quantities. Generating such tissue i
Externí odkaz:
https://doaj.org/article/8cabbf931a364048830c83f3d92ee7ad