Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Robin Plevin"'
Autor:
Christopher Riley, Usama Ammar, Aisha Alsfouk, Nahoum G. Anthony, Jessica Baiget, Giacomo Berretta, David Breen, Judith Huggan, Christopher Lawson, Kathryn McIntosh, Robin Plevin, Colin J. Suckling, Louise C. Young, Andrew Paul, Simon P. Mackay
Publikováno v:
Molecules, Vol 29, Iss 15, p 3515 (2024)
The inhibitory-kappaB kinases (IKKs) IKKα and IKKβ play central roles in regulating the non-canonical and canonical NF-κB signalling pathways. Whilst the proteins that transduce the signals of each pathway have been extensively characterised, the
Externí odkaz:
https://doaj.org/article/e3e2e03e3b834ed6981a0d5113267e5c
Autor:
Shalmali Patkar, Dafe Uwanogho, Michel Modo, Rothwelle J. Tate, Robin Plevin, Hilary V. O. Carswell
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Dax-1 (dosage-sensitive sex reversal adrenal hypoplasia congenital region on X-chromosome gene 1) blocks 17β-estradiol biosynthesis and its knockdown would be expected to increase 17β-estradiol production. We hypothesized that knockdown of Dax-1 in
Externí odkaz:
https://doaj.org/article/61187a76e35041b3a5cd3c7189a35120
Autor:
Juliane Schroeder, Kirsty Ross, Kathryn McIntosh, Shilan Jabber, Stuart Woods, Jenny Crowe, Janet Patterson Kane, James Alexander, Catherine Lawrence, Robin Plevin
Publikováno v:
RMD Open, Vol 5, Iss 1 (2019)
Objectives We have previously shown mitogen-activated protein kinase phosphatase 2 (MKP-2) to be a key regulator of proinflammatory cytokines in macrophages. In the study presented here, we investigated the role of MKP-2 in inflammatory arthritis wit
Externí odkaz:
https://doaj.org/article/af16d99b350249eca6ff4e9b3973b3d3
Autor:
Stuart Woods, Juliane Schroeder, Helen A. McGachy, Robin Plevin, Craig W. Roberts, James Alexander
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9 (2013)
Externí odkaz:
https://doaj.org/article/e305a2f8759d46e5a3b9a5c857c9bb2b
Autor:
Stuart Woods, Juliane Schroeder, Helen A McGachy, Robin Plevin, Craig W Roberts, James Alexander
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003535 (2013)
The dual specific phosphatase, MAP kinase phosphatase-2 (MKP-2) has recently been demonstrated to negatively regulate macrophage arginase-1 expression, while at the same time to positively regulate iNOS expression. Consequently, MKP-2 is likely to pl
Externí odkaz:
https://doaj.org/article/24e880428d8349f5a3197c0ce0bbafef
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 2, p e2064 (2013)
We have recently demonstrated that MAP kinase phosphatase 2 (MKP-2) deficient C57BL/6 mice, unlike their wild-type counterparts, are unable to control infection with the protozoan parasite Leishmania mexicana. Increased susceptibility was associated
Externí odkaz:
https://doaj.org/article/c28e91fdf12c4b88a267b26f2158b4db
Autor:
Mashael S Al-Mutairi, Laurence C Cadalbert, H Adrienne McGachy, Muhannad Shweash, Juliane Schroeder, Magdalena Kurnik, Callum M Sloss, Clare E Bryant, James Alexander, Robin Plevin
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001192 (2010)
In this study we generated a novel dual specific phosphatase 4 (DUSP4) deletion mouse using a targeted deletion strategy in order to examine the role of MAP kinase phosphatase-2 (MKP-2) in immune responses. Lipopolysaccharide (LPS) induced a rapid, t
Externí odkaz:
https://doaj.org/article/8b370344e4b845929912de640584ece4
Autor:
Kathryn McIntosh, Yousif H. Khalaf, Rachel Craig, Christopher West, Ashley McCulloch, Ajay Waghmare, Christopher Lawson, Edmond Y.W. Chan, Simon Mackay, Andrew Paul, Robin Plevin
Publikováno v:
Cellular Signalling. 107:110684
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::614598f3e7f58b50225b555cdb1bd5aa
https://doi.org/10.1016/j.cellsig.2023.110684
https://doi.org/10.1016/j.cellsig.2023.110684
Publikováno v:
Biochemical Society Transactions
Protease-activated receptor-2 (PAR2) has been extensively studied since its discovery in the mid-1990. Despite the advances in understanding PAR2 pharmacology, it has taken almost 25 years for the first inhibitor to reach clinical trials, and so far,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799c9851c40df95c7eeb3abbfa3dcb2a
https://doi.org/10.1042/bst20200191
https://doi.org/10.1042/bst20200191
Autor:
John C. Lockhart, Carl S. Goodyear, Kathryn McIntosh, S.L. Martin, Lynette Dunning, Anne Crilly, Gerard P. Sergeant, Mariarca Bailo, Robin Plevin, Joanna Brzeszczynska, G. S. Litherland
Publikováno v:
Airway cell biology and immunopathology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f72a8c5fd78617003409ce83170069df
https://doi.org/10.1183/13993003.congress-2020.2292
https://doi.org/10.1183/13993003.congress-2020.2292