Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robin Pedersen"'
Autor:
Özgün Özalay, Tomas Mediavilla, Bruno Lima Giacobbo, Robin Pedersen, Daniel Marcellino, Greger Orädd, Anna Rieckmann, Fahad Sultan
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The human aging brain is characterized by changes in network efficiency that are currently best captured through longitudinal resting-state functional MRI (rs-fMRI). These studies however are challenging due to the long human lifespan. Here
Externí odkaz:
https://doaj.org/article/bd0dc510930d41da8f27604d19ff40ac
Autor:
Jarkko Johansson, Kristin Nordin, Robin Pedersen, Nina Karalija, Goran Papenberg, Micael Andersson, Saana M. Korkki, Katrine Riklund, Marc Guitart-Masip, Anna Rieckmann, Lars Bäckman, Lars Nyberg, Alireza Salami
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113107- (2023)
Summary: Age-related alterations in D1-like dopamine receptor (D1DR) have distinct implications for human cognition and behavior during development and aging, but the timing of these periods remains undefined. Enabled by a large sample of in vivo ass
Externí odkaz:
https://doaj.org/article/cdf7672086dd4497b4cc3fbcd2956210
Autor:
Lars Nyberg, Nina Karalija, Goran Papenberg, Alireza Salami, Micael Andersson, Robin Pedersen, Tomas Vikner, Douglas D. Garrett, Katrine Riklund, Anders Wåhlin, Martin Lövdén, Ulman Lindenberger, Lars Bäckman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Cognitive functions are well-preserved for some older individuals, but the underlying brain mechanisms remain disputed. Here, 5-year longitudinal 3-back in-scanner and offline data classified individuals in a healthy older sample (baseline a
Externí odkaz:
https://doaj.org/article/43df79de146a44cc84de35d419a2fd9e
Publikováno v:
Aging Brain, Vol 3, Iss , Pp 100079- (2023)
Past research has shown that as individuals age, there are decreases in within-network connectivity and increases in between-network connectivity, a pattern known as functional dedifferentiation. While the mechanisms behind reduced network segregatio
Externí odkaz:
https://doaj.org/article/824d57063419408c821276dfa1a7dadd
Autor:
Robin Pedersen, Linda Geerligs, Micael Andersson, Tetiana Gorbach, Bárbara Avelar-Pereira, Anders Wåhlin, Anna Rieckmann, Lars Nyberg, Alireza Salami
Publikováno v:
NeuroImage, Vol 242, Iss , Pp 118449- (2021)
Healthy aging is accompanied by progressive decline in cognitive performance and concomitant changes in brain structure and functional architecture. Age-accompanied alterations in brain function have been characterized on a network level as weaker fu
Externí odkaz:
https://doaj.org/article/2bed8de990c146398a2ebce51ed1d2dd
Autor:
Kristin Nordin, Robin Pedersen, Farshad Falahati, Jarkko Johansson, Filip Grill, Micael Andersson, Saana Korkki, Lars Bäckman, Andrew Zalesky, Anna Rieckmann, Lars Nyberg, Alireza Salami
The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. A multidimensional account of the hippocampus functional integration with neocortex, however, remains to be established and evaluated in terms of func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ae146b2ef3ba984675922526f03ff05
https://doi.org/10.1101/2023.03.24.534115
https://doi.org/10.1101/2023.03.24.534115
Autor:
Jarkko Johansson, Kristin Nordin, Robin Pedersen, Nina Karalija, Goran Papenberg, Micael Andersson, Saana M. Korkki, Katrine Riklund, Marc Guitart-Masip, Anna Rieckmann, Lars Bäckman, Lars Nyberg, Alireza Salami
The dopamine (DA) system, particularly D1-like DA receptors (D1DR), declines across the adult life. The functional consequences of reduced D1DR has been hypothesized to vary across life periods, but the precise timing of these periods is unknown. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30e7f1d367fad214eb30e653c0387a0c
https://doi.org/10.1101/2022.05.24.493225
https://doi.org/10.1101/2022.05.24.493225
Autor:
Kristin Nordin, Tetiana Gorbach, Robin Pedersen, Vania Panes Lundmark, Jarkko Johansson, Micael Andersson, Charlotte McNulty, Katrine Riklund, Anders Wåhlin, Goran Papenberg, Grégoria Kalpouzos, Lars Bäckman, Alireza Salami
Publikováno v:
Journal of neuroscience research. 100(6)
Concomitant exploration of structural, functional, and neurochemical brain mechanisms underlying age-related cognitive decline is crucial in promoting healthy aging. Here, we present the DopamiNe, Age, connectoMe, and Cognition (DyNAMiC) project, a m
Autor:
Barb Brandhuber, Stephen S. Gonzales, Guy Vigers, Kevin Ronald Condroski, Jed Pheneger, Patrice Lee, Allen A. Thomas, Y. Le Huerou, J. De Meese, Robin Pedersen, Jie Lin, Todd Romoff, Greg Poch, Christine Lemieux, Gunawardana Indrani W, Boyd Steven A, May Han, Francis X. Sullivan, Darin Smith, Bryan Bernat, Tomas Kaplan, Walter E. DeWolf, Josh Ballard, S. Kirk Wright, Solly Weiler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2206-2210
Tumor cells extensively utilize the pentose phosphate pathway for the synthesis of ribose. Transketolase is a key enzyme in this pathway and has been suggested as a target for inhibition in the treatment of cancer. In a pharmacodynamic study, nude mi
Autor:
Chatanika Stoop-Myer, Robin Pedersen, Vic E. Myer, Sena Jong, Yuji Mishina, Brent L. Kreider, Susan K. Lyman, Chris Wilson, Jesse J. Smith, Linda Bruett, Lizabeth P. Amaral, Craig M. Thompson
Publikováno v:
SLAS Discovery. 9:196-207
G protein-coupled receptors (GPCRs) are a superfamily of proteins that include some of the most important drug targets in the pharmaceutical industry. Despite the success of this group of drugs, there remains a need to identify GPCR-targeted drugs wi