Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors

Autor: Amanda Rosewell Shaw, Caroline E. Porter, Tiffany Yip, Way-Champ Mah, Mary K. McKenna, Matthew Dysthe, Youngrock Jung, Robin Parihar, Malcolm K. Brenner, Masataka Suzuki

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Rosewell Shaw et al. show that a previously developed immunotherapy strategy, coupling oncolytic adenoviral immunotherapy with clinically tested HER2-specific CAR T-cells, is effective against pancreatic ductal adenocarcinoma (PDAC). This combination

Externí odkaz: https://doaj.org/article/6c619b9e136441a696783c518011c56f

Book of Abstracts: 2019 Health Equity Summer Research Summit Organized by the Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas 77030, USA on June 18th, 2019

Autor: A Uribe-Gomez, Abraham A. Salinas-Miranda, MD, PhD, Acara E. Turner, BS, Adriana M. Strutt, PhD, ABPP, Adrienne Joseph, BS, Alex Wright, BS, Alexander C. Martin, BS, Alexis N. Milton, BS, Amelia Khoei, BS, Amritha Kanakamedala, BA, Angie Iyinbor, BA, Anna O’Neal, BS, Asha Morrow, MD, Ashley M. Butler, PhD, Ashley Young, BS, Asim Shah, MD, Asna Matin, MD, Audrey E. Christiansen, PhD, Boubakari Ibrahimou, PhD, Breanna Alonzo, Chase Ossenkop, BS, Carli O’Neal, BS, Chih-Wei Hsu, PhD, Charles Ikeanyionwu, BS, Chinwe Anyanwu, MPH, Charlotte Rivas, BS, Chioma A. Ikedionwu, BS, Chioma Anugwom, BS, Christopher R. Broda, MD, Claire Bocchini, MD, Claire Cummins, MD, Cliona M. Rooney, PhD, Colton L. Keo-Meier, PhD, Connor Johnson, BS, Courtney Miller-Chism, MD, Courtney Titus, MEd, Crystal L. Parker, MPH, Cylaina Bird, BA, Daniel Mauck, MPH, David Persse, MD, FACEP, Deborah A. Austin, PhD, Deepa Dongarwar, MS, Deepa V. Cherla, MD, Dwayne Wolf, MD, Ph.D, Eleanor Bimla Schwartz, MD, MS, Elena Petrova, PhD, Elias Perli, BS, Elisabeth Shell, PhD, PA-C, Elizabeth U. Tran, MD, Elsa Baena, PhD, Elyse Lopez, BS, Estrellita “Lo” Berry, MPA, Evadne Rodriguez, BA, Fabrizia Faustinella, MD, PhD, FACP, Faith D. Ihekweazu, MD, MS, Faiz Jiwani, MD, MS, Gabriella P. Chmaitelli, BS, Galant Chan, MD, Haijun Wang, PhD, MPH, Hamisu M. Salihu, MD, PhD, Hannah L. Combs, PhD, Hayley Rogers, BS, Heather Haq, MD, MHS, Iberia Romina Sosa, MD, PhD, Irene E. Jose, BS, Isabel Griffin, MPH, J. Cao, Jane Montealegre, PhD, Jason L. Salemi, PhD, MPH, Jennifer Chang, PhD, Jennifer M. Stinson, PhD, JL Mills, Joann Schulte, DO, MPH, Joel Thomas, John Prochaska, PhD, John Saunders, MD, MS, Jonathan Go, BBA, Jonathan Lim, MD, Jordan Salley, BS, Josue Estiven Pineda, BS, Jules Tabilona, MD, Julie L. Holihan, MD, MS, Kanika Bowen-Jallow, MD, MMS, Karla Bernardi, MD, Karla Fredricks, MD, MPH, Katherine B. Salciccioli, MD, Keila N. Lopez, MD,MPH, Kenneth Barning, MD, Kevin Dat Vuong, MA, Korede K. Yusuf, MBBS, PhD, Kristopher Myers, MPH, Kyle Wilson, Larry E. Laufman, EdD, Latanya J. Love, MD, Lauren Nolan, BA, Lauren Schoen, Lillian Huang, MD, Lindsey M. King, PhD, MPH, Lisa F. Nunez, BS, Louis Brown, PhD, Luna Hernandez, Lynn Hydod, M. Agustina Rossetti, PhD, Madeleine Allman, MPH, Mahmood Khan, MD, Makenna Marty, MAS, MaKenzie D. Lee, BS, Maria A. Jaramillo, BS, Maria Vigil, BS, Mariaelena Boyle, Marina Masciale, MD, Marisa Hilliard, PhD, Marisela Munoz, Mary E. Dickinson, PhD, Meishon Bell, MS, Michele K. York, PhD, Michelle Loor, MD, Michelle Lopez, MD, MPH, Mike K. Liang, MD, Moez Karim Aziz, MSECE, Moriel Karla, BS, Nancy Osazuma, Natalya Ramirez, BS, Natasha Navejar, BS, Nicolás Cortés-Penfield, MD, Nicole B. Lyons, BS, Norma Perez, MD, DrPH, NR Barshes, Olivia A. Barron, BA, Oscar A. Olavarria, MD, Petra Constable, BA, Phyllis Nwokolo, BS, Precious Omokaro, BS, Premal Patel, MD, Prithvi Vallabh, BS, Puja Shah, BA, Rafeek A. Yusuf, MD, MS, MPH, Rebecca A. Rosero, BA, Rebecca Lunstroth, JD, MA, Renice Obure, MPH, Robert Beach, MD, Robin Goin-Kochel, PhD, Robin Parihar, MD, PhD, Roger Zoorob, MD, MPH, Ronee E. Wilson, PhD, Rosa Michelle Schmidt, MD, MPH, Rowland Pettit, BS, Sade C. Udoetuk, MD, Sadia Tasnim, Sara Khan, BA, Sareema Adnan, BS, Sean Rodriguez, BA, Sharmila Anandasabapathy, MD, Shawna Nesbitt, MD, Sheena Bhushan, MD, Sherene Sharath, SO Rogers, Son Dinh, BSA, Sophia Banu, MD, Stacey Rose, MD, FACP, Stacy Drake, Ph.D, MPH, RN, AFN-BC, D-AB, Stephanie Morain, PhD, MPH, Stephen R. McCauley, PhD, Sue Abdelaziz, BS, Tahir Malik, BS, Tara L. Rasmussen, PhD, Thomas Shum, Tiana Raphel, BA, Tien C. Ko, MD, Toi Harris, MD, Trevor Hadley, BS, Uchechukwu Akoma, BS, Uwem Bridgette Eduok, BSA, Victoria Armendariz, MS, Yasmin C. Cole-Lewis, PhD, MPH, Zaina Al-Mohtaseb, MD, Zenab Yusuf, MD, MPH

Publikováno v: International Journal of Maternal and Child Health and AIDS, Vol 9, Iss 2s (2020)

Copyright © 2020 Harris. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cit

Externí odkaz: https://doaj.org/article/67bfadcd915c47518aabd4323cdec3f7

TGF-β1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy

Autor: Padmini Jayaraman, Falguni Parikh, Jared M. Newton, Aurelie Hanoteau, Charlotte Rivas, Rosemarie Krupar, Kimal Rajapakshe, Ravi Pathak, Kavin Kanthaswamy, Cassie MacLaren, Shixia Huang, Cristian Coarfa, Chad Spanos, Dean P. Edwards, Robin Parihar, Andrew G. Sikora

Publikováno v: OncoImmunology, Vol 7, Iss 10 (2018)

Cancer-induced myeloid-derived suppressor cells (MDSC) play an important role in tumor immune evasion. MDSC programming or polarization has been proposed as a strategy for leveraging the developmental plasticity of myeloid cells to reverse MDSC immun

Externí odkaz: https://doaj.org/article/83f7a6009b6146aaa71b466f52fbd60c

Data from NK Cells Expressing a Chimeric Activating Receptor Eliminate MDSCs and Rescue Impaired CAR-T Cell Activity against Solid Tumors

Autor: Cliona M. Rooney, Stephen M. Gottschalk, Leonid S. Metelitsa, Natalia Lapteva, Bilal Omer, Mai Huynh, Charlotte Rivas, Robin Parihar

Solid tumors are refractory to cellular immunotherapies in part because they contain suppressive immune effectors such as myeloid-derived suppressor cells (MDSCs) that inhibit cytotoxic lymphocytes. Strategies to reverse the suppressive tumor microen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee879a054753ff8c7775a258778f03b
https://doi.org/10.1158/2326-6066.c.6549822.v1

Supplemental Figure 6 from Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells

Autor: Cliona M. Rooney, Stephen Gottschalk, Leonid S. Metelitsa, Malcolm K. Brenner, Hao Liu, Paul Castillo, Robin Parihar, Daofeng Liu, Tim Sauer, Zhongzhen Yi, Kathan Parikh, Dimitrios L. Wagner, Robert L. Kruse, Haruko Tashiro, Bilal Omer, Thomas Shum

Supplementary Figure 6: Efficient retroviral transduction of T-cells with Î"34, C7R, GD2-CAR, and GD2-CAR.C7R constructs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9834a0d5003b2bdaa1de1ab2deeb6bfd
https://doi.org/10.1158/2159-8290.22532015.v1