Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Robin P. Wharton"'
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194865 (2018)
Drosophila Pumilio (Pum) is a founding member of the conserved Puf domain class of RNA-binding translational regulators. Pum binds with high specificity, contacting eight nucleotides, one with each of the repeats in its RNA-binding domain. In general
Externí odkaz:
https://doaj.org/article/f9cc9084b7284689a1bceb6703b4e824
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194865 (2018)
PLoS ONE
PLoS ONE
Drosophila Pumilio (Pum) is a founding member of the conserved Puf domain class of RNA-binding translational regulators. Pum binds with high specificity, contacting eight nucleotides, one with each of the repeats in its RNA-binding domain. In general
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765ab7ec3d2a199678a636b59b8ac864
https://doi.org/10.1371/journal.pone.0194865
https://doi.org/10.1371/journal.pone.0194865
Autor:
Carlos R. Escalante, Aneel K. Aggarwal, Robin P. Wharton, Lyudmila Y. Kadyrova, Tammy H. Lee, Yogesh K. Gupta, Thomas A. Edwards
Publikováno v:
RNA. 15:1029-1035
Pumilio controls a number of processes in eukaryotes, including the translational repression of hunchback (hb) mRNA in early Drosophila embryos. The Pumilio Puf domain binds to a pair of 32 nucleotide (nt) Nanos response elements (NRE1 and NRE2) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb0c55701eb03935fa9df9897482b89
https://doi.org/10.1261/rna.1327609
https://doi.org/10.1261/rna.1327609
Structures of Human Pumilio with Noncognate RNAs Reveal Molecular Mechanisms for Binding Promiscuity
Publikováno v:
Structure. 16:549-557
Summary Pumilio is a founder member of the evolutionarily conserved Puf family of RNA-binding proteins that control a number of physiological processes in eukaryotes. A structure of human Pumilio (hPum) Puf domain bound to a Drosophila regulatory seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d4417052909ad06b9ffb13735ef451
https://doi.org/10.1016/j.str.2008.01.006
https://doi.org/10.1016/j.str.2008.01.006
Publikováno v:
Genetics. 176:2213-2222
Localization of maternal nanos mRNA to the posterior pole is essential for development of both the abdominal segments and primordial germ cells in the Drosophila embryo. Unlike maternal mRNAs such as bicoid and oskar that are localized by directed tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19e408fa46545b80af351ff9b04b19c
https://doi.org/10.1534/genetics.107.071472
https://doi.org/10.1534/genetics.107.071472
Publikováno v:
Development. 134:1519-1527
In the Drosophila embryo, Nanos and Pumilio collaborate to repress the translation of hunchback mRNA in the somatic cytoplasm. Both proteins are also required for repression of maternal Cyclin B mRNA in the germline; it has not been clear whether the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377031331727305e7b2e7556ed638131
https://doi.org/10.1242/dev.002212
https://doi.org/10.1242/dev.002212
Publikováno v:
Developmental Cell. 10:441-449
SummaryAn important question in stem cell biology is how a cell decides to self-renew or differentiate. Drosophila neuroblasts divide asymmetrically to self-renew and generate differentiating progeny called GMCs. Here, we report that the Brain tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd65591794fee0e10d312ac22d54000
https://doi.org/10.1016/j.devcel.2006.01.017
https://doi.org/10.1016/j.devcel.2006.01.017
Autor:
Yogesh K. Gupta, Arthur G. Palmer, Xin Wang, Lei Zeng, Joel A. Butterwick, Thomas A. Edwards, Aneel K. Aggarwal, Robin P. Wharton
Publikováno v:
Journal of Molecular Biology. 356:1065-1072
The yeast Vts1 SAM (sterile alpha motif) domain is a member of a new class of SAM domains that specifically bind RNA. To elucidate the structural basis for RNA binding, the solution structure of the Vts1 SAM domain, in the presence of a specific targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab1a1cbb36e269dc25135d71e456cf3
https://doi.org/10.1016/j.jmb.2005.12.004
https://doi.org/10.1016/j.jmb.2005.12.004
Publikováno v:
The EMBO Journal. 22:6115-6126
The initiation of DNA synthesis is thought to occur at sites bound by a heteromeric origin recognition complex (ORC). Previously, we have shown that in Drosophila, the level of the large subunit, ORC1, is modulated during cell cycle progression and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e91d7e60173a013685c7fcbb9e3fe9e
https://doi.org/10.1093/emboj/cdg573
https://doi.org/10.1093/emboj/cdg573
Publikováno v:
Genes & Development. 17:2508-2513
The Brain Tumor (Brat) protein is recruited to the 3′ untranslated region (UTR) of hunchback mRNA to regulate its translation. Recruitment is mediated by interactions between the Pumilio RNA-binding Puf repeats and the NHL domain of Brat, a conserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b20e34e65f385f7afccae678989e7b
https://doi.org/10.1101/gad.1119403
https://doi.org/10.1101/gad.1119403