Polarity signaling balances epithelial contractility and mechanical resistance

Autor: Matthias Rübsam, Robin Püllen, Frederik Tellkamp, Alessandra Bianco, Marc Peskoller, Wilhelm Bloch, Kathleen J. Green, Rudolf Merkel, Bernd Hoffmann, Sara A. Wickström, Carien M. Niessen

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Epithelia maintain a functional barrier during tissue turnover while facing varying mechanical stress. This maintenance requires both dynamic cell rearrangements driven by actomyosin-linked intercellular adherens junctions and ability to ada

Externí odkaz: https://doaj.org/article/49b8af49c71147bfa299ecb65e9ed353

Skin under Strain: From Epithelial Model Tissues to Adult Epithelia

Autor: Robin Püllen, Jens Konrad, Rudolf Merkel, Bernd Hoffmann

Publikováno v: Cells, Vol 10, Iss 7, p 1834 (2021)

Formation of a barrier capable of protecting tissue from external damage, chemical factors, and pathogens is one of the main functions of the epidermis. Furthermore, upon development and during aging, mechanoprotective epidermal functions change dram

Externí odkaz: https://doaj.org/article/f143e3ca74634eb18dc3c6584e330e20

Cell Stretcher Assay to Analyze Mechanoresponses to Cyclic Stretching

Autor: Robin, Püllen, Jens, Konrad, Bernd, Hoffmann, Rudolf, Merkel

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2600

In their natural environment, most cells and tissues are continuously exposed to cyclic mechanical strain. Sensing these stimuli by mechanosensory proteins and subsequent conversion into a variety of biological responses (referred to as mechanotransd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1e5550ab5a7494f4dfc3abb301101ee
https://pubmed.ncbi.nlm.nih.gov/36587092

MAdCAM-1/α4β7 Integrin-Mediated Lymphocyte/Endothelium Interactions Exacerbate Acute Immune-Mediated Hepatitis in Mice

Autor: Klaus Tenbrock, Jessica Hübel, Angela Schippers, Sreepradha Eswaran, Sarah Schlepütz, Nikolaus Gaßler, Felix Heymann, Thomas Clahsen, Robin Püllen, Frank Tacke, Norbert Wagner

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology : CMGH 11(4), 1227-1250.el (2021). doi:10.1016/j.jcmgh.2020.12.003
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1227-1250.e1 (2021)

Background & Aims Aberrant lymphocyte homing could potentially link inflammatory processes in the intestine and the liver, as distinct hepatobiliary diseases frequently develop as extra-intestinal manifestations in inflammatory bowel disease. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0be119be2e0b93fcb11bc9ccf1947d3
http://europepmc.org/articles/PMC8053699