Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Robin N Beech"'
Autor:
Jennifer D Noonan, Robin N Beech
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010962 (2022)
Neurotransmission is an important target for anthelmintic drugs, where receptor characteristics and response can be examined through reconstitution ex vivo in Xenopus laevis oocytes. The homomeric ACR-16 nicotine sensitive acetylcholine receptors (N-
Externí odkaz:
https://doaj.org/article/80c5440af64e414f8cfcb5a4ee12662f
Autor:
Alexandra Blanchard, Fabrice Guégnard, Claude L Charvet, Anna Crisford, Elise Courtot, Christine Sauvé, Abdallah Harmache, Thomas Duguet, Vincent O'Connor, Philippe Castagnone-Sereno, Barbara Reaves, Adrian J Wolstenholme, Robin N Beech, Lindy Holden-Dye, Cedric Neveu
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1006996 (2018)
Cholinergic agonists such as levamisole and pyrantel are widely used as anthelmintics to treat parasitic nematode infestations. These drugs elicit spastic paralysis by activating acetylcholine receptors (AChRs) expressed in nematode body wall muscles
Externí odkaz:
https://doaj.org/article/28410ae1fb11412eb1de52ffddf3d9f6
Autor:
Fanfan Li, Mohammadamin Shahsavarani, Cody-Jordan Handy-Hart, Audrey Côté, Xavier Brasseur-Trottier, Victoria Montgomery, Robin N. Beech, Lan Liu, Stéphane Bayen, Yang Qu, Vincenzo De Luca, Mehran Dastmalchi
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Monoterpenoid indole alkaloid (MIA) biosynthesis in Catharanthus roseus is a paragon of the spatiotemporal complexity achievable by plant specialized metabolism. Spanning a range of tissues, four cell types, and five cellular organelles, MIA
Externí odkaz:
https://doaj.org/article/fe11ce71bc4c4964afaef963581c5cf3
Autor:
Thomas B Duguet, Claude L Charvet, Sean G Forrester, Claudia M Wever, Joseph A Dent, Cedric Neveu, Robin N Beech
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004826 (2016)
Helminth parasites rely on fast-synaptic transmission in their neuromusculature to experience the outside world and respond to it. Acetylcholine plays a pivotal role in this and its receptors are targeted by a wide variety of both natural and synthet
Externí odkaz:
https://doaj.org/article/371b1798dcb24cd888a2df12fb70ba77
Autor:
Elise Courtot, Claude L Charvet, Robin N Beech, Abdallah Harmache, Adrian J Wolstenholme, Lindy Holden-Dye, Vincent O'Connor, Nicolas Peineau, Debra J Woods, Cedric Neveu
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005267 (2015)
Acetylcholine receptors are pentameric ligand-gated channels involved in excitatory neuro-transmission in both vertebrates and invertebrates. In nematodes, they represent major targets for cholinergic agonist or antagonist anthelmintic drugs. Despite
Externí odkaz:
https://doaj.org/article/0e442599256b407ca8e198036851e625
Autor:
Mohamed Issouf, Fabrice Guégnard, Christine Koch, Yves Le Vern, Alexandra Blanchard-Letort, Hua Che, Robin N Beech, Dominique Kerboeuf, Cedric Neveu
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87802 (2014)
Eosinophils are one of the major mammalian effector cells encountered by helminths during infection. In the present study, we investigated the effects of eosinophil granule exposure on the sheep parasitic nematode Haemonchus contortus as a model. H.
Externí odkaz:
https://doaj.org/article/8b9a6b59c96e4279ba57e3d577d41a54
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003586 (2013)
Cys-loop ligand-gated ion channels (LGICs) mediate fast ionotropic neurotransmission. They are proven drug targets in nematodes and arthropods, but are poorly characterized in flatworms. In this study, we characterized the anion-selective, non-acetyl
Externí odkaz:
https://doaj.org/article/a233d3aff8dd4063bde55c97eecca554
Autor:
Jennifer D. Noonan, Robin N. Beech
Nicotinic acetylcholine receptors (N-AChRs) mediate fast synaptic signalling and are members of the pentameric ligand-gated ion channel (pLGIC) family. They rely on a network of accessory proteinsin vivofor correct formation and transport to the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d343d654b363449b22afa6f0a82cbebf
https://doi.org/10.1101/2023.01.22.525060
https://doi.org/10.1101/2023.01.22.525060
Autor:
Jennifer D. Noonan, Robin N. Beech
Neurotransmission is an important target for anthelmintic drugs, where receptor characteristics and response can be examined through reconstitution ex vivo in Xenopus laevis oocytes. The homomeric ACR-16 nicotine sensitive acetylcholine receptors (N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40fdcfd7a033be01831171ea95ccdf40
https://doi.org/10.1101/2022.06.01.493574
https://doi.org/10.1101/2022.06.01.493574
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss, Pp 112380-(2022)
Background and purpose Nematode glutamate-gated chloride channels (GluCls) are targets of ivermectin (IVM) and moxidectin (MOX), structurally dissimilar macrocyclic lactone (ML) anthelmintics. IVM and MOX possess different pharmacokinetics and effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e299cf77616a99c900909ea21a59c1
https://pubmed.ncbi.nlm.nih.gov/34749053
https://pubmed.ncbi.nlm.nih.gov/34749053