Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Robin Meccariello"'
Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation
Autor:
Christopher Beneduce, Stephanie Nguyen, Nathaniel Washburn, John Schaeck, Robin Meccariello, Kimberly Holte, Daniel Ortiz, Anthony M. Manning, Carlos J. Bosques, Elma Kurtagic
Publikováno v:
Cells, Vol 12, Iss 17, p 2130 (2023)
Immunoglobulin (IgG) Fc glycosylation has been shown to be important for the biological activity of antibodies. Fc sialylation is important for the anti-inflammatory activity of IgGs. However, evaluating the structure–activity relationship (SAR) of
Externí odkaz:
https://doaj.org/article/596cb9d1b1e841fbb5b6fd29af19e280
Autor:
Victor Farutin, Thomas Prod’homme, Kevin McConnell, Nathaniel Washburn, Patrick Halvey, Carol J. Etzel, Jamey Guess, Jay Duffner, Kristen Getchell, Robin Meccariello, Bryan Gutierrez, Christopher Honan, Ganlin Zhao, Nicholas A. Cilfone, Nur Sibel Gunay, Jan L. Hillson, David S. DeLuca, Katherine C. Saunders, Dimitrios A. Pappas, Jeffrey D. Greenberg, Joel M. Kremer, Anthony M. Manning, Leona E. Ling, Ishan Capila
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-14 (2019)
Abstract Background The goal of this study is to use comprehensive molecular profiling to characterize clinical response to anti-TNF therapy in a real-world setting and identify reproducible markers differentiating good responders and non-responders
Externí odkaz:
https://doaj.org/article/3e82234a9ea54de3a35f19b6cf0f9913
Autor:
Nathaniel Washburn, Robin Meccariello, Shaohui Hu, Maurice Hains, Naveen Bhatnagar, Hetal Sarvaiya, Bulbul Kapoor, John Schaeck, Ignacio Pino, Anthony Manning, Jonathan C Lansing, Carlos J Bosques
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181251 (2017)
Intravenous immunoglobulin (IVIg) is a complex mixture drug comprising diverse immunoglobulins and non-IgG proteins purified from the plasma of thousands of healthy donors. Approved IVIg products on the market differ regarding source of plasma, isola
Externí odkaz:
https://doaj.org/article/810e740f2ece44d3987135491a036d73
Autor:
David S. DeLuca, Jan Hillson, Katherine C. Saunders, Jamey Guess, Joel M. Kremer, Patrick Halvey, Kristen Getchell, Carol J. Etzel, Anthony M. Manning, Robin Meccariello, Nicholas A. Cilfone, Victor Farutin, Ishan Capila, Kevin Mcconnell, Jay Duffner, Christopher M. Honan, Thomas Prod’homme, Bryan Gutierrez, Dimitrios A. Pappas, Leona E. Ling, Jeff Greenberg, Nur Sibel Gunay, Nathaniel Washburn, Ganlin Zhao
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-14 (2019)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background The goal of this study is to use comprehensive molecular profiling to characterize clinical response to anti-TNF therapy in a real-world setting and identify reproducible markers differentiating good responders and non-responders in rheuma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec39902ea115bac26c85502cefad6669
http://link.springer.com/article/10.1186/s13075-019-1999-3
http://link.springer.com/article/10.1186/s13075-019-1999-3
Autor:
Robert Prenovitz, Nathaniel Washburn, Jay Duffner, Carlos J. Bosques, Anthony M. Manning, Ganesh Kaundinya, Robin Meccariello, Jonathan C. Lansing, Thomas Prod’homme, Ishan Capila, Karunya Srinivasan, Kristen Getchell, Kimberly Holte
Publikováno v:
Molecular & Cellular Proteomics : MCP
Characterization of endogenous FcγRIII glycosylation from healthy donors with different FcγRIIIb genotypes reveals site specific, and allele specific differences in glycosylation as well as noncananonical sequence specific differences in glycosylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefb5da0df94b01a05bcaf91520eaf3c
https://doi.org/10.1074/mcp.ra118.001142
https://doi.org/10.1074/mcp.ra118.001142
Autor:
Laura Rutitzky, Daniel F. Ortiz, Jonathan C. Lansing, Julia Brown, Joseph Paquette, Kevin Garofalo, Josephine D'Alessandro, Naveen Bhatnagar, Maurice Hains, Abhinav Gupta, Stan Lee, Radouane Zouaoui, Jason Wang, John Schaeck, Salvatore Marchese, Robin Meccariello, Nathaniel Washburn, Kimberly Holte, Carlos J. Bosques, Anthony M. Manning
Publikováno v:
Cancer Research. 79:3244-3244
Numerous therapeutic monoclonal antibodies (mAbs) rely on antibody-dependent cell cytotoxicity (ADCC), antibody-dependent cell phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC) Fc effector functions to deplete target cells and achieve c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf0c014a499f281c36f74e93ab3210ff
https://doi.org/10.1158/1538-7445.am2019-3244
https://doi.org/10.1158/1538-7445.am2019-3244
Autor:
Maurice Hains, Kimberly Holte, Amit Choudhury, Daniel Ortiz, Christopher Beneduce, Jonathan C. Lansing, Thomas Prod’homme, Steven Tyler, Robert Prenovitz, Lynn Markowitz, Elma Kurtagic, Allison Simpson, Laura I. Rutitzky, Julia Brown, Leona E. Ling, Stephanie Nguyen, Birgit Schultes, Ishan Capila, Anthony M. Manning, Robin Meccariello, Inessa Schwab, Nathaniel Washburn, Carlos J. Bosques, Matthew A. Child, Radouane Zouaoui, Jason Killough, Falk Nimmerjahn, Jing Wang, Naveen Bhatnagar
Publikováno v:
Science Translational Medicine. 8
Autoantibody immune complex (IC) activation of Fcγ receptors (FcγRs) is a common pathogenic hallmark of multiple autoimmune diseases. Given that the IC structural features that elicit FcγR activation are poorly understood and the FcγR system is h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccfaa1f5bb42ddec8bfc28ba84dedf7
https://doi.org/10.1126/scitranslmed.aaf9418
https://doi.org/10.1126/scitranslmed.aaf9418
Autor:
Steven Tyler, Leona E. Ling, Jonathan C. Lansing, Laura I. Rutitzky, Hetal Sarvaiya, Amy Medeiros, Daniel Ortiz, Naveen Bhatnagar, Kevin Garofalo, Falk Nimmerjahn, Edward Cochran, Carlos J. Bosques, Nathaniel Washburn, Anthony M. Manning, Robin Meccariello, William Avery, Birgit Schultes, James Meador, Inessa Schwab, Divya J. Mekala, Ganesh Kaundinya
Publikováno v:
Proceedings of the National Academy of Sciences. 112
Despite the beneficial therapeutic effects of intravenous immunoglobulin (IVIg) in inflammatory diseases, consistent therapeutic efficacy and potency remain major limitations for patients and physicians using IVIg. These limitations have stimulated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a93fdeadc93b03126a40f1d4dfb6624
https://doi.org/10.1073/pnas.1422481112
https://doi.org/10.1073/pnas.1422481112
Autor:
Ignacio Pino, John Schaeck, Nathaniel Washburn, Naveen Bhatnagar, Jonathan C. Lansing, Shaohui Hu, Anthony M. Manning, Robin Meccariello, Bulbul Kapoor, Hetal Sarvaiya, Maurice Hains, Carlos J. Bosques
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181251 (2017)
PLoS ONE, Vol 12, Iss 7, p e0181251 (2017)
Intravenous immunoglobulin (IVIg) is a complex mixture drug comprising diverse immunoglobulins and non-IgG proteins purified from the plasma of thousands of healthy donors. Approved IVIg products on the market differ regarding source of plasma, isola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5eb188857aca08a0eb1096395186bd7
https://doi.org/10.1371/journal.pone.0181251
https://doi.org/10.1371/journal.pone.0181251
Autor:
Sucharita Roy, Leona E. Ling, Sandra F Sipsey, Ganesh Kaundinya, Karunya Srinivasan, Nathaniel Washburn, Anthony M. Manning, Robin Meccariello, James Meador
Publikováno v:
Journal of Biomolecular Screening
Fidelity of glycan structures is a key requirement for biotherapeutics, with carbohydrates playing an important role for therapeutic efficacy. Comprehensive glycan profiling techniques such as liquid chromatography (LC) and mass spectrometry (MS), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937e2dd723af815370f81ee52f856a54
https://pubmed.ncbi.nlm.nih.gov/25851037
https://pubmed.ncbi.nlm.nih.gov/25851037