Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robin M. de Kruijff"'
Autor:
Svenja Trapp, Tom Lammers, Gokce Engudar, Cornelia Hoehr, Antonia G. Denkova, Elisabeth Paulssen, Robin M. de Kruijff
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Background The radionuclide Ga-68 is commonly used in nuclear medicine, specifically in positron emission tomography (PET). Recently, the interest in producing Ga-68 by cyclotron irradiation of [68Zn]Zn nitrate liquid targets is increasing.
Externí odkaz:
https://doaj.org/article/7d3404d2e5ba43d89d4e126022cc02a4
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Iron deficiency anemia can be treated with oral or intravenous Fe supplementation. Such supplementation has considerable effects on the human microbiome, and on opportunistic pathogenic micro-organisms. Molecular understanding of the control and regu
Externí odkaz:
https://doaj.org/article/351190266d2c469e8b217001285d2e82
Publikováno v:
Pharmaceuticals, Vol 8, Iss 2, Pp 321-336 (2015)
This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and
Externí odkaz:
https://doaj.org/article/efa726463b3947648e12724a6ebab611
Autor:
Robin M. de Kruijff, René Raavé, Annemarie Kip, Janneke Molkenboer-Kuenen, Stefan J. Roobol, Jeroen Essers, Sandra Heskamp, Antonia G. Denkova
Publikováno v:
Pharmaceutics, Vol 11, Iss 5, p 241 (2019)
The use of nanoparticles as tumor-targeting agents is steadily increasing, and the influence of nanoparticle characteristics such as size and stealthiness have been established for a large number of nanocarrier systems. However, not much is known abo
Externí odkaz:
https://doaj.org/article/2a3362d91cbc4dd8a8e6df2eea300891
Autor:
Irene Piergentili, Pepijn R. Bouwmans, Luuk Reinalda, Reece W. Lewis, Benjamin Klemm, Huanhuan Liu, Robin M. de Kruijff, Antonia G. Denkova, Rienk Eelkema
Publikováno v:
Polymer Chemistry, 13
In certain tumor and diseased tissues, reactive oxygen species (ROS), such as H2O2, are produced in higher concentrations than in healthy cells. Drug delivery and release systems that respond selectively to the presence of ROS, while maintaining thei
Autor:
Huanhuan Liu, Robin M. de Kruijff, Adrianus C. Laan, Freek J. Beekman, Eline van den Heuvel, Ruud M. Ramakers, Rienk Eelkema, Antonia G. Denkova
Publikováno v:
Advanced Therapeutics, 5(9)
A variety of polymer micelles are designed for the delivery of chemotherapeutic drugs to tumors. Although the promise of these nanocarriers is very high, in the clinic the effectivity is rather limited. Determining the in vivo fate of the micelles ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d73f48bba30c8aaa12461df3209ff9
https://doi.org/10.1002/adtp.202200077
https://doi.org/10.1002/adtp.202200077
Autor:
Guzman Torrelo, Tsion E Abraham, Frank Bruchertseifer, Robin M. de Kruijff, Dik C. van Gent, Martin E. van Royen, Adriaan B Houtsmuller, Thomas A Hartjes, Roland Kanaar, Antonia G. Denkova, Jeroen Essers, Alfred Morgenstern, Johan A. Slotman, Stefan J. Roobol
Publikováno v:
Nanotheranostics, 4, 14-25. Ivyspring International Publishers
Nanotheranostics, 4(1)
Nanotheranostics
Nanotheranostics, 4(1)
Nanotheranostics
Polymersomes have the potential to be applied in targeted alpha radionuclide therapy, while in addition preventing release of recoiling daughter isotopes. In this study, we investigated the cellular uptake, post uptake processing and intracellular lo
Autor:
Peter Sminia, Robin M. de Kruijff, Helga E. de Vries, Gabriel Becerril Aragon, Ravi S. Narayan, Susanne M A van der Pol, Guzman Torrelo Villa, Ana Gasol Garcia, Fatima Bikhezar, Ben J. Slotman, Astrid J.G.M. van der Meer, Antonia G. Denkova
Publikováno v:
Journal of Neuro-Oncology
Bikhezar, F, de Kruijff, R M, van der Meer, A J G M, Torrelo Villa, G, van der Pol, S M A, Becerril Aragon, G, Gasol Garcia, A, Narayan, R S, de Vries, H E, Slotman, B J, Denkova, A G & Sminia, P 2020, ' Preclinical evaluation of binimetinib (MEK162) delivered via polymeric nanocarriers in combination with radiation and temozolomide in glioma ', Journal of Neuro-Oncology, vol. 146, no. 2, pp. 239-246 . https://doi.org/10.1007/s11060-019-03365-y, https://doi.org/10.1007/s11060-019-03365-y
Journal of Neuro-Oncology, 146(2), 239-246. Kluwer Academic Publishers
Journal of Neuro-Oncology, 146(2)
Bikhezar, F, de Kruijff, R M, van der Meer, A J G M, Torrelo Villa, G, van der Pol, S M A, Becerril Aragon, G, Gasol Garcia, A, Narayan, R S, de Vries, H E, Slotman, B J, Denkova, A G & Sminia, P 2020, ' Preclinical evaluation of binimetinib (MEK162) delivered via polymeric nanocarriers in combination with radiation and temozolomide in glioma ', Journal of Neuro-Oncology, vol. 146, no. 2, pp. 239-246 . https://doi.org/10.1007/s11060-019-03365-y, https://doi.org/10.1007/s11060-019-03365-y
Journal of Neuro-Oncology, 146(2), 239-246. Kluwer Academic Publishers
Journal of Neuro-Oncology, 146(2)
Background and purpose Glioblastoma multiforme (GBM) is the most aggressive subtype of malignant gliomas, with an average survival rate of 15 months after diagnosis. More than 90% of all GBMs have activating mutations in the MAPK/ERK pathway. Recentl
Autor:
Robin M. de Kruijff, Antonia G. Denkova, Rienk Eelkema, Benjamin Klemm, Pepijn R. Bouwmans, Luuk Reinalda, Huanhuan Liu, Reece W. Lewis, Irene Piergentili
In certain tumor and diseased tissues, reactive oxygen species (ROS), such as H2O2, are produced in higher concentrations than in healthy cells. To date, only few examples of drug delivery and release systems responds selectively to these small but s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0af563c70e3d72707994e6f2d644ee
https://doi.org/10.33774/chemrxiv-2021-5wn7m
https://doi.org/10.33774/chemrxiv-2021-5wn7m
Publikováno v:
Angewandte Chemie. 131:3840-3843
Here we report on how metastable supramolecular gels can be formed through seeded self-assembly of multicomponent gelators. Hydrazone-based gelators decorated with non-ionic and anionic groups are formed in situ from hydrazide and aldehyde building b