Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Robin M. Hallett"'
Autor:
William D. Gwynne, Mirza S. Shakeel, Jianhan Wu, Robin M. Hallett, Adele Girgis-Gabardo, Anna Dvorkin-Gheva, John A. Hassell
Publikováno v:
Cellular & Molecular Biology Letters, Vol 24, Iss 1, Pp 1-13 (2019)
Abstract Background Breast tumor growth and recurrence are driven by an infrequent population of breast tumor-initiating cells (BTIC). We and others have reported that the frequency of BTIC is orders of magnitude higher when breast tumor cells are pr
Externí odkaz:
https://doaj.org/article/00b38dd4e70b45fc949157a9595cd2a2
Autor:
Joan Seoane, Patricia Giblin, Jean-Philippe Julien, Judit Anido, Isabel Huber-Ruano, Johan Fransson, Dorothea Maetzel, Melissa Beilschmidt, Alexandre Bosch, Esther Lau, AJ Robert McGray, Almudena Neva-Alejo, Olga Egorova, Peter Bayliss, Swetha Raman, Alexandra Arias, Raffaella Iurlaro, Ester Bonfill-Teixidor, Robin M. Hallett
Supplementary Table 1: Description of TCGA derived mRNA expression cohorts used to examine LIF expression and associated transcript signaturesSupplementary Table 2: Transcription signatures used to identify biological processes and cell types correla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e876e51551f962bd9d5d74e20b1d20a
https://doi.org/10.1158/1078-0432.22482800
https://doi.org/10.1158/1078-0432.22482800
Autor:
Joan Seoane, Patricia Giblin, Jean-Philippe Julien, Judit Anido, Isabel Huber-Ruano, Johan Fransson, Dorothea Maetzel, Melissa Beilschmidt, Alexandre Bosch, Esther Lau, AJ Robert McGray, Almudena Neva-Alejo, Olga Egorova, Peter Bayliss, Swetha Raman, Alexandra Arias, Raffaella Iurlaro, Ester Bonfill-Teixidor, Robin M. Hallett
Supplementary Figure 1. Transcriptomic analysis demonstrates an enrichment of immunological pathways in high LIF tumors. Supplementary Figure 2. LIF transcripts are associated with a panel of immunosuppressive macrophage/myeloid signatures across hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b4731b9846b1639fb87315ef90e1b6
https://doi.org/10.1158/1078-0432.22482803
https://doi.org/10.1158/1078-0432.22482803
Autor:
Joan Seoane, Patricia Giblin, Jean-Philippe Julien, Judit Anido, Isabel Huber-Ruano, Johan Fransson, Dorothea Maetzel, Melissa Beilschmidt, Alexandre Bosch, Esther Lau, AJ Robert McGray, Almudena Neva-Alejo, Olga Egorova, Peter Bayliss, Swetha Raman, Alexandra Arias, Raffaella Iurlaro, Ester Bonfill-Teixidor, Robin M. Hallett
Purpose:Leukemia inhibitory factor (LIF) is a multifunctional cytokine with numerous reported roles in cancer and is thought to drive tumor development and progression. Characterization of LIF and clinical-stage LIF inhibitors would increase our unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b3ecc064e7d4473e93036075979191
https://doi.org/10.1158/1078-0432.c.6530999.v1
https://doi.org/10.1158/1078-0432.c.6530999.v1
Autor:
Robin M. Hallett, Ester Bonfill-Teixidor, Raffaella Iurlaro, Alexandra Arias, Swetha Raman, Peter Bayliss, Olga Egorova, Almudena Neva-Alejo, AJ Robert McGray, Esther Lau, Alexandre Bosch, Melissa Beilschmidt, Dorothea Maetzel, Johan Fransson, Isabel Huber-Ruano, Judit Anido, Jean-Philippe Julien, Patricia Giblin, Joan Seoane
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research.
Purpose:Leukemia inhibitory factor (LIF) is a multifunctional cytokine with numerous reported roles in cancer and is thought to drive tumor development and progression. Characterization of LIF and clinical-stage LIF inhibitors would increase our unde
Autor:
Kay Dias, Anna Dvorkin-Gheva, Robin M Hallett, Ying Wu, John Hassell, Gregory R Pond, Mark Levine, Tim Whelan, Anita L Bane
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168669 (2017)
Claudin-low breast cancer is a molecular type of breast cancer originally identified by gene expression profiling and reportedly associated with poor survival. Claudin-low tumors have been recognised to preferentially display a triple-negative phenot
Externí odkaz:
https://doaj.org/article/146be580e3a043cd912b1c4b420888d3
Autor:
Minomi Subapanditha, Chitra Venugopal, Neil Winegarden, Ashley A. Adile, Robin M. Hallett, Blake Yarascavitch, John Provias, David Bakhshinyan, Blessing Bassey-Archibong, Neil Savage, Bradley W. Doble, Laura M. Richards, Dillon McKenna, Trevor J. Pugh, Olufemi Ajani, Owen Whitley, Nazanin Tatari, Michelle Kameda-Smith, Adam Fleming, Anna Dvorkin-Gheva, Branavan Manoranjan, Sheila K. Singh, Gary D. Bader
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Medulloblastoma (MB) is defined by four molecular subgroups (Wnt, Shh, Group 3, Group 4) with Wnt MB having the most favorable prognosis. Since prior reports have illustrated the antitumorigenic role of Wnt activation in Shh MB, we aimed to assess th
Autor:
Robin M. Hallett, Sarah E. Poplawski, Mark H. Dornan, Shin Hye Ahn, Shuang Pan, Wu Wengen, Liu Yuxin, David G. Sanford, Valerie S. Hergott, Quang-De Nguyen, Anthony P. Belanger, Jack H. Lai, William Bachovchin, Joe A. McCann
Publikováno v:
Cancer Research. 82:3303-3303
Background: Fibroblast Activation Protein-α (FAP) is a transmembrane glycoprotein highly expressed on activated fibroblasts. It is a constitutively active 170 kDa serine protease and a member of the dipeptide peptidase (DPP) family, sharing ~50% hom
Autor:
Blake Yarascavitch, Hamza Farooq, Minomi Subapanditha, Vijay Ramaswamy, Wu Du, Nicole McFarlane, Olufemi Ajani, Sheila K. Singh, Thomas W. Davis, Marla Weetall, Nadiya Sydorenko, Robin M. Hallett, Ashley A. Adile, David L. Kaplan, Aneet Mann, Parvez Vora, Chang Sun Lee, Thusyanth Vijayakumar, Neha Garg, Michael D. Taylor, David Bakhshinyan, Xin Wang, Chitra Venugopal, Sorana Morrissy, Brad Doble, Jacek M. Kwiecien, Michelle Kameda-Smith, Siddhartha Mitra, Mohini Singh, Sujeivan Mahendram, Kathleen H. Delaney, Ramil Baiazitov, Liangxian Cao, Josephine Sheedy, Yoon Jae Cho, Branavan Manoranjan, Young Choon Moon, Maleeha Qazi
Publikováno v:
Oncogene. 38:1702-1716
Medulloblastoma (MB) is the most frequent malignant pediatric brain tumor, representing 20% of newly diagnosed childhood central nervous system malignancies. Although advances in multimodal therapy yielded a 5-year survivorship of 80%, MB still accou
Autor:
Craig Aarts, Adele Girgis-Gabardo, Robin M. Hallett, Anita Bane, Bojana Bojovic, Anna Dvorkin-Gheva, William D. Gwynne, Kay Dias, John A. Hassell
Publikováno v:
Oncotarget
Breast tumors comprise an infrequent tumor cell population, termed breast tumor initiating cells (BTIC), which sustain tumor growth, seed metastases and resist cytotoxic therapies. Hence therapies are needed to target BTIC to provide more durable bre