Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Robin M. Bush"'
Autor:
Rommie E. Amaro, Pek U Ieong, Gary Huber, Abigail Dommer, Alasdair C. Steven, Robin M. Bush, Jacob D. Durrant, Lane W. Votapka
Publikováno v:
ACS Central Science, Vol 4, Iss 11, Pp 1570-1577 (2018)
Externí odkaz:
https://doaj.org/article/fc06bd50c75b4f429bfae9d13556a2dd
Autor:
Pek U Ieong, Lane W. Votapka, Gary A. Huber, Jacob D. Durrant, Robin M. Bush, Alasdair C. Steven, Rommie E. Amaro, Abigail C. Dommer
Publikováno v:
ACS central science, vol 4, iss 11
ACS Central Science, Vol 4, Iss 11, Pp 1570-1577 (2018)
ACS Central Science
Amaro, Rommie E; Ieong, Pek U; Huber, Gary; Dommer, Abigail; Steven, Alasdair C; Bush, Robin M; et al.(2018). A Computational Assay that Explores the Hemagglutinin/Neuraminidase Functional Balance Reveals the Neuraminidase Secondary Site as a Novel Anti-Influenza Target. ACS CENTRAL SCIENCE, 4(11), 1570-1577. doi: 10.1021/acscentsci.8b00666. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2fk411cc
ACS Central Science, Vol 4, Iss 11, Pp 1570-1577 (2018)
ACS Central Science
Amaro, Rommie E; Ieong, Pek U; Huber, Gary; Dommer, Abigail; Steven, Alasdair C; Bush, Robin M; et al.(2018). A Computational Assay that Explores the Hemagglutinin/Neuraminidase Functional Balance Reveals the Neuraminidase Secondary Site as a Novel Anti-Influenza Target. ACS CENTRAL SCIENCE, 4(11), 1570-1577. doi: 10.1021/acscentsci.8b00666. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2fk411cc
Studies of pathogen–host specificity, virulence, and transmissibility are critical for basic research as well as for assessing the pandemic potential of emerging infectious diseases. This is especially true for viruses such as influenza, which cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a803ae15a82b06d699ce4b94d24a72a4
https://escholarship.org/uc/item/2fk411cc
https://escholarship.org/uc/item/2fk411cc
Autor:
Steven A. Frank, Robin M. Bush
Publikováno v:
SSRN Electronic Journal.
People who work with animals are frequently exposed to dangerous pathogens. Disease and subsequent immunity may result. Alternatively, occupational exposure to animals may lead to natural vaccination: the acquisition of immunity in the absence of ove
Publikováno v:
Durrant, JD; Bush, RM; & Amaro, RE. (2016). Microsecond Molecular Dynamics Simulations of Influenza Neuraminidase Suggest a Mechanism for the Increased Virulence of Stalk-Deletion Mutants. JOURNAL OF PHYSICAL CHEMISTRY B, 120(33), 8590-8599. doi: 10.1021/acs.jpcb.6b02655. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6h06q75z
The Journal of Physical Chemistry. B
The journal of physical chemistry. B, vol 120, iss 33
The Journal of Physical Chemistry. B
The journal of physical chemistry. B, vol 120, iss 33
Deletions in the stalk of the influenza neuraminidase (NA) surface protein are associated with increased virulence, but the mechanisms responsible for this enhanced virulence are unclear. Here we use microsecond molecular dynamics simulations to expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c4179a8568a3de16ffed2b92090c17
http://www.escholarship.org/uc/item/6h06q75z
http://www.escholarship.org/uc/item/6h06q75z
Autor:
Robin M. Bush, María José Rodríguez-Marañón, Luis M. de la Maza, Tilman Schirmer, Ellena M. Peterson
Publikováno v:
Protein Science. 11:1854-1861
There is preliminary experimental evidence indicating that the major outer-membrane protein (MOMP) of Chlamydia is a porin. We tested this hypothesis for the MOMP of the mouse pneumonitis serovar of Chlamydia trachomatis using two secondary structure
Autor:
Robin M. Bush, Neil M. Ferguson
Publikováno v:
International Congress Series. 1263:12-16
Given its antigenic variability, transmissibility and high mutation rate, the limited genetic diversity of influenza A subtypes and the relative constancy of this diversity over time is surprising. While the mechanisms driving the emergence of new st
Publikováno v:
Nature. 422:428-433
In pandemic and epidemic forms, influenza causes substantial, sometimes catastrophic, morbidity and mortality. Intense selection from the host immune system drives antigenic change in influenza A and B, resulting in continuous replacement of circulat
Publikováno v:
International Congress Series. 1219:147-153
Background: The hemagglutinins (HA) of human influenza viruses adapt during growth in chicken eggs. Amino acid replacements in HAs of egg-grown viruses generally appear on the terminal branches of phylogenetic trees. Our method for predicting human i
Autor:
Robin M. Bush, Karin D. E. Everett
Publikováno v:
International Journal of Systematic and Evolutionary Microbiology. 51:203-220
Phylogenetic analyses of surface antigens and other chlamydial proteins were used to reconstruct the evolution of the Chlamydiaceae. Trees for all five coding genes [the major outer-membrane protein (MOMP), GroEL chaperonin, KDO-transferase, small cy
Publikováno v:
Proceedings of the National Academy of Sciences. 97:6974-6980
In this paper we determine the extent to which host-mediated mutations and a known sampling bias affect evolutionary studies of human influenza A. Previous phylogenetic reconstruction of influenza A (H3N2) evolution using the hemagglutinin gene revea