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pro vyhledávání: '"Robin Levy"'
Publikováno v:
Biomolecules, Vol 9, Iss 3, p 83 (2019)
The disordered p53 transactivation domain (p53TAD) contains specific levels of transient helical secondary structure that are necessary for its binding to the negative regulators, mouse double minute 2 (Mdm2) and MdmX. The interactions of p53 with Md
Externí odkaz:
https://doaj.org/article/5147ba3f4eed4838bbae5c577139c52e
Autor:
Malissa Fenton, Wade Borcherds, Lihong Chen, Asokan Anbanandam, Robin Levy, Jiandong Chen, Gary Daughdrill
Publikováno v:
Journal of Molecular Biology. 434:167844
Autoinhibition of p53 binding to MDMX requires two short-linear motifs (SLiMs) containing adjacent tryptophan (WW) and tryptophan-phenylalanine (WF) residues. NMR spectroscopy was used to show the WW and WF motifs directly compete for the p53 binding
Publikováno v:
Biophysical Journal. 118:215a