Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Robin L. Wesselschmidt"'
Stem cells are self-replicating and undifferentiated, meaning their function is not yet cell, tissue, or organ-specific. Due to the unique nature of these cells, research into their biology and function holds great promise for therapeutic application
Publikováno v:
Neuromethods ISBN: 9781493970223
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85bdee826548dede881c057515f06c08
https://doi.org/10.1007/978-1-4939-7024-7_15
https://doi.org/10.1007/978-1-4939-7024-7_15
Publikováno v:
Journal of Biological Chemistry. 284:12940-12948
Ryk is a Wnt receptor that plays an important role in neurogenesis, neurite outgrowth, and axon guidance. We have reported that the Ryk receptor is cleaved by γ-secretase and that its intracellular domain (ICD) translocates to the nucleus upon Wnt s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000550ba61cc578e34b315ed356c8860
https://doi.org/10.1074/jbc.m900207200
https://doi.org/10.1074/jbc.m900207200
Publikováno v:
In Vitro Cellular & Developmental Biology - Animal. 45:1-5
Insulin-secreting pancreatic beta-cells play a key role in the pathogenesis of diabetes mellitus. Potential new treatments for this disease include cell-replacement therapies using embryonic stem cells (ESCs). We have generated ESCs from a transgenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223de0c1b6bc1647a430241feb218f46
https://doi.org/10.1007/s11626-008-9142-9
https://doi.org/10.1007/s11626-008-9142-9
Autor:
Chih-Lin Hsieh, Robin L. Wesselschmidt, Thomas M. Ryan, Tim M. Townes, Timothy A. Graubert, Bruce A. Hug, Timothy J. Ley
Publikováno v:
Nucleic Acids Research. 26:2849-2858
The random insertion of transgenes into the genomic DNA of mice usually leads to widely variable levels of expression in individual founder lines. To study the mechanisms that cause variegation, we designed a transgene that we expected to variegate,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4279267a601596a5d9ca987cfb432b
https://doi.org/10.1093/nar/26.12.2849
https://doi.org/10.1093/nar/26.12.2849
Publikováno v:
Blood. 89:376-387
Acute promyelocytic leukemia (APML) is characterized by abnormal myeloid development, resulting an accumulation of leukemic promyelocytes that are often highly sensitive to retinoic acid. A balanced t(15; 17) (q22; q21) reciprocal chromosomal translo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99fc89757823a2455f4470348f45e48c
https://doi.org/10.1182/blood.v89.2.376
https://doi.org/10.1182/blood.v89.2.376
Publikováno v:
Immunity. 5(5):491-501
We have generated mice carrying a homozygous null mutation in the granulocyte colony-stimulating factor receptor (G-CSFR) gene. G-CSFR-deficient mice have decreased numbers of phenotypically normal circulating neutrophils. Hematopoietic progenitors a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7c9ab228abc33764cf59e8ebe4d01d
Autor:
Steven Fiering, Bruce A. Hug, M. A. Bender, Timothy J. Ley, Elliot Epner, Robin L. Wesselschmidt, Mark Groudine
Publikováno v:
Molecular and Cellular Biology. 16:2906-2912
To examine the function of murine beta-globin locus region (LCR) 5' hypersensitive site 3 (HS3) in its native chromosomal context, we deleted this site from the mouse germ line by using homologous recombination techniques. Previous experiments with h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9ea4c2d38191a618115bca87935da3
https://doi.org/10.1128/mcb.16.6.2906
https://doi.org/10.1128/mcb.16.6.2906
Publikováno v:
Proceedings of the National Academy of Sciences. 93:3942-3946
Macrophages secrete a variety of proteinases that are thought to participate in remodeling of the extracellular matrix associated with inflammatory processes. We have eliminated expression of the macrophage metalloelastase (MME) gene by targeted disr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7f5cfa30c145b0c761c4c13a59df39
https://doi.org/10.1073/pnas.93.9.3942
https://doi.org/10.1073/pnas.93.9.3942
Autor:
Stephen L. Lee, Jeffrey Milbrandt, John H. Russell, Osami Kanagawa, Robin L. Wesselschmidt, Gerald P. Linette
Publikováno v:
Science. 269:532-535
T cell hybridomas require the immediate-early gene NGFI-B (nur77) for T cell receptor (TCR)-mediated apoptosis, a model for negative selection of self-reactive T cells. TCR-mediated death was examined in mice bearing an NGFI-B loss-of-function mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a7e70188fbca553e54fc71440be090
https://doi.org/10.1126/science.7624775
https://doi.org/10.1126/science.7624775