Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair.

Autor: Kelly Beagan, Robin L Armstrong, Alice Witsell, Upasana Roy, Nikolai Renedo, Amy E Baker, Orlando D Schärer, Mitch McVey

Publikováno v: PLoS Genetics, Vol 13, Iss 5, p e1006813 (2017)

Double strand breaks (DSBs) and interstrand crosslinks (ICLs) are toxic DNA lesions that can be repaired through multiple pathways, some of which involve shared proteins. One of these proteins, DNA Polymerase θ (Pol θ), coordinates a mutagenic DSB

Externí odkaz: https://doaj.org/article/424f94cfac564df49822bba40c3fbed3

Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 inDrosophila melanogaster

Autor: Aaron T Crain, Stephen Klusza, Robin L Armstrong, Priscila Santa Rosa, Brenda R S Temple, Brian D Strahl, Daniel J McKay, A Gregory Matera, Robert J Duronio

Publikováno v: Genetics

Mono-methylation of histone H4 lysine 20 (H4K20me1) is catalyzed by Set8/KMT5A and regulates numerous aspects of genome organization and function. Loss-of-function mutations in Drosophila melanogaster Set8 or mammalian KMT5A prevent H4K20me1 and disr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40b1cb886b1e522428935e1d6454897
https://doi.org/10.1093/genetics/iyac054

Early multidrug treatment of SARS-CoV-2 infection (COVID-19) and reduced mortality among nursing home (or outpatient/ambulatory) residents

Autor: Robin L. Armstrong, Craig M. Wax, Peter A. McCullough, Ramin Oskoui, Harvey A. Risch, Parvez Dara, Howard C. Tenenbaum, Paul E. Alexander, John Lotus, Chad Prodromos, George Fareed, Kulvinder K. Gill

Publikováno v: Medical Hypotheses

The outbreak of COVID-19 from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread all over the world with tremendous morbidity and mortality in the elderly. In-hospital treatment addresses the multifaceted nature of the illness in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7077121bdda6e694b6aa5cb7ebb831
https://pubmed.ncbi.nlm.nih.gov/34130113

Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)

Autor: John Littell, Alexandre Giandoni Wolkoff, Karladine E. Graves, Russell S. Gonnering, Stella Immanuel, John E. McKinnon, Sabine Hazan, Lee D. Merritt, Brian C. Procter, Richard A. Eisner, Robin L. Armstrong, Donald C. Pompan, Martin Scholz, Michael J. A. Robb, Kelly Victory, Vladimir Zelenko, Peter A. McCullough, Salete da Silva Rios, Richard P. Bartlett, Craig M. Wax, Paul E. Alexander, Vicki Wooll, Robert Berkowitz, Charles E. Geyer, Kristin S. Held, George Fareed, Juliana Cepelowicz Rajter, Harvey A. Risch, Molly Rutherford, Richard G. Urso, Roland Derwand, Adam Brufsky, Teryn Clarke, Lionel H. Lee, Chad Prodromos, Ivette Lozano, Ben Marble, Harpal S. Mangat, Thomas J. Borody, Jane M. Orient, Silvia Nunes Szente Fonseca, John Eck, Joseph H. Brewer, Brian M. Tyson, Angelina Farella, Ramin Oskoui, Joseph A. Ladapo, Marilyn M. Singleton, Andrew C. Berry, Alan F. Bain, Cristian Arvinte, Michael M. Jacobs, Kenneth B. V. Gross, Elizabeth Lee Vliet, Jean-Jacques Rajter, James A. Tumlin, Alieta Eck, H. Thomas Hight, C. Venkata S. Ram

Publikováno v: Reviews in Cardiovascular Medicine, Vol 21, Iss 4, Pp 517-530 (2020)
Repositório Institucional da UnB
Universidade de Brasília (UnB)
instacron:UNB

The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine stor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3d15452c8df06e4dcda7102fe62c82
http://hdl.handle.net/11375/26557

Phasing in heterochromatin during development

Autor: Robert J. Duronio, Robin L. Armstrong

Acquisition of chromatin modifications during embryogenesis distinguishes different regions of an initially naïve genome. In many organisms, repetitive DNA is packaged into constitutive heterochromatin that is marked by di/trimethylation of histone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8c6494b8632b29d49f19f915559563
https://europepmc.org/articles/PMC6446546/