Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Robin Kirwan"'
Autor:
Dongfang Meng, Dann L. Parker, Robin Kirwan, M A Powles, Jennifer Nielsen Kahn, James M. Apgar, Fred Racine, Paul A. Liberator, Amy M. Flattery, Andrew Galgoci, Kingsley H. Nelson, James M. Balkovec, Andrew S. Misura, Weiming Fan, Donald M. Sperbeck, Michael Robert Peel, Robert A. Giacobbe, Mark L. Greenlee, Ahmed Mamai, Jasminka Dragovic, Kenneth J. Wildonger, Hao Liu, Robert R. Wilkening, Mary Motyl, Shu Lee, Ming-Jo Hsu, Charles Gill, George K. Abruzzo
Publikováno v:
Bioorganicmedicinal chemistry letters. 32
We previously reported medicinal chemistry efforts that identified MK-5204, an orally efficacious β-1,3-glucan synthesis inhibitor derived from the natural product enfumafungin. Further extensive optimization of the C2 triazole substituent identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9a5b1dc4caa4f8e8040bb53f3f65ed
https://pubmed.ncbi.nlm.nih.gov/33160023
https://pubmed.ncbi.nlm.nih.gov/33160023
Autor:
James M. Balkovec, Robert A. Giacobbe, Jennifer Nielsen Kahn, Ming Jo Hsu, Weiming Fan, Ahmed Mamai, Michael Robert Peel, James M. Apgar, Amy M. Flattery, Paul A. Liberator, Fred Racine, Bahanu Habulihaz, Mary Motyl, Kingsley H. Nelson, Robert R. Wilkening, Robin Kirwan, M A Powles, George K. Abruzzo, Andrew Galgoci, Charles Gill, Andrew S. Misura, Shu Lee, Jasminka Dragovic, Hao Liu, Mark L. Greenlee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5813-5818
The clinical success of the echinocandins, which can only be administered parentally, has validated β-1,3-glucan synthase (GS) as an antifungal target. Semi-synthetic modification of enfumafungin, a triterpene glycoside natural product, was performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f12625a2e82e86dbbc4c61aa3a8424
https://doi.org/10.1016/j.bmcl.2015.10.011
https://doi.org/10.1016/j.bmcl.2015.10.011