Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Robin K. Minor"'
Autor:
Robin K. Minor
Publikováno v:
Teaching and Learning Excellence through Scholarship, Vol 1, Iss 1 (2021)
LETTER FROM THE EDITOR Robin K. Minor, PhD Associate Professor of Biology, Community College of Baltimore County
Externí odkaz:
https://doaj.org/article/2781df7a027942d295bc1dbb36137add
Autor:
Sarah J. Mitchell, Alejandro Martin-Montalvo, Evi M. Mercken, Hector H. Palacios, Theresa M. Ward, Gelareh Abulwerdi, Robin K. Minor, George P. Vlasuk, James L. Ellis, David A. Sinclair, John Dawson, David B. Allison, Yongqing Zhang, Kevin G. Becker, Michel Bernier, Rafael de Cabo
Publikováno v:
Cell Reports, Vol 6, Iss 5, Pp 836-843 (2014)
The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care system. Activation of sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, improves metabolism and c
Externí odkaz:
https://doaj.org/article/4311e779c1b84073a91f71df14820ee9
Autor:
Jordan J Licata, Robin K. Minor, Gelareh Abulwerdi, Christoph H. Westphal, Theresa M. Ward, James L. Ellis, Hector H. Palacios, David A. Sinclair, Peter J. Elliott, Sarah J. Mitchell, Michel Bernier, Rafael de Cabo, Nathan L. Price, Dushani L. Palliyaguru
Publikováno v:
J Gerontol A Biol Sci Med Sci
SRT1720, a sirtuin1-activator, and metformin (MET), an antidiabetic drug, confer health and life-span benefits when administered individually. It is unclear whether combination of the two compounds could lead to additional benefits. Groups of 56-week
Autor:
Kevin G. Becker, James L. Ellis, Rafael de Cabo, Sarah J. Mitchell, Hector H. Palacios, Evi M. Mercken, Maria Almeida, Yongqing Zhang, Ana P. Gomes, Michel Bernier, Robin K. Minor, Alejandro Martin-Montalvo, Joseph A. Baur, Morten Scheibye-Knudsen, Peter J. Elliott, Husam Khraiwesh, José A. González-Reyes, Jordan J Licata, José M. Villalba, Christoph H. Westphal, David A. Sinclair, George P. Vlasuk
Publikováno v:
Aging Cell
Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice f
Publikováno v:
Nature Reviews Drug Discovery. 11:443-461
Although the increased lifespan of our populations illustrates the success of modern medicine, the risk of developing many diseases increases exponentially with old age. Caloric restriction is known to retard ageing and delay functional decline as we
Autor:
Carlos Dieguez, Rafael de Cabo, Miguel López, Caitlin M. Younts, Bruce Jones, Robert Michael Anson, Robin K. Minor, Kevin J. Pearson
Publikováno v:
Aging Cell. 10:483-492
Calorie restriction (CR) is known to have profound effects on tumor incidence. A typical consequence of CR is hunger, and we hypothesized that the neuroendocrine response to CR might in part mediate CR's antitumor effects. We tested CR under appetite
Publikováno v:
Molecular and Cellular Endocrinology. 299:79-88
Laboratory studies consistently demonstrate extended lifespan in animals on calorie restriction (CR), where total caloric intake is reduced by 10–40% but adequate nutrition is otherwise maintained. CR has been further shown to delay the onset and s
Autor:
Edward L. Spangler, Jonna L. Bowker, Adrienne Hagepanos, Zhihong Guo, Anne M. Janas, James A. Joseph, Peter R. Mouton, Kara B. Duffy, Rafael deCabo, Donald K. Ingram, Barbara Shukitt-Hale, Robin K. Minor, Bryan D. Devan
Publikováno v:
Neurobiology of Aging. 29:1680-1689
Young male Fischer-344 rats were fed a diet containing 2% blueberry (BB) extract or control diet for at least 8 weeks and then received bilateral hippocampal injections of kainic acid (KA 200 ng/0.5 microl) or phosphate buffered saline (PBS). One wee
Autor:
Kevin J. Pearson, William R. Swindell, Nancy Pleshko, Yongqing Zhang, Evelyn Perez, Nazar Labinskyy, Joseph A. Baur, Anna Csiszar, Kevin G. Becker, Zoltan Ungvari, Peter J. Elliott, Yuji Ikeno, Kaitlyn N. Lewis, Plácido Navas, Hamish A. Jamieson, Robin K. Minor, Rafael de Cabo, Leonid Peshkin, Nathan L. Price, David G. Le Couteur, Donald K. Ingram, Davida Kamara, Laura A. Woollett, Norman S. Wolf, Stephen R. Dunn, Kumar Sharma, David A. Sinclair
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
22 páginas, 4 figuras.
A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lo
A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lo
Autor:
Johan Auwerx, Yongqing Zhang, Carles Cantó, Melissa Krawczyk, David A. Sinclair, Christoph H. Westphal, George P. Vlasuk, Elin Lehrmann, Evi M. Mercken, Kevin G. Becker, Joseph A. Baur, Zoltan Ungvari, Morten Scheibye-Knudsen, Rafael de Cabo, Myriam Gorospe, William R. Swindell, Josephine M. Egan, Nathan L. Price, Basil P. Hubbard, Peter J. Elliott, Robin K. Minor, Theresa M. Ward, Alexa A. White, James L. Ellis, Kotb Abdelmohsen, Pablo M. Irusta, Vilhelm A. Bohr, Mark I. Talan, Yu Kyong Shin, Ana P. Gomes, Anna Csiszar, Alejandro Martin-Montalvo, Kevin J. Pearson
Publikováno v:
Scientific Reports. 3
Sirt1 is an NAD+-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to ac