Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Robin J.M. Franklin"'
Autor:
Sara Kohnke, Sophie Buller, Danae Nuzzaci, Katherine Ridley, Brian Lam, Helena Pivonkova, Marie A. Bentsen, Kimberly M. Alonge, Chao Zhao, John Tadross, Staffan Holmqvist, Takahiro Shimizo, Hannah Hathaway, Huiliang Li, Wendy Macklin, Michael W. Schwartz, William D. Richardson, Giles S.H. Yeo, Robin J.M. Franklin, Ragnhildur T. Karadottir, David H. Rowitch, Clemence Blouet
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109362- (2021)
Summary: The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance of energy bala
Externí odkaz:
https://doaj.org/article/5e36423c8b584650a2ec34b1447ad29b
Autor:
Joshua D. Bernstock, Luca Peruzzotti-Jametti, Tommaso Leonardi, Nunzio Vicario, Daniel Ye, Yang-ja Lee, Dragan Maric, Kory R. Johnson, Yongshan Mou, Aletta Van Den Bosch, Mark Winterbone, Gregory K. Friedman, Robin J.M. Franklin, John M. Hallenbeck, Stefano Pluchino
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 214-224 (2019)
Background: Neural stem cell (NSC)-based therapies hold great promise for treating diseases of the central nervous system (CNS). However, several fundamental problems still need to be overcome to fully exploit the clinical potential of NSC therapeuti
Externí odkaz:
https://doaj.org/article/51b3c9761dd24ed6a276bc078074ab7f
Autor:
Alerie Guzman De La Fuente, Simona Lange, Maria Elena Silva, Ginez A. Gonzalez, Herbert Tempfer, Peter van Wijngaarden, Chao Zhao, Ludovica Di Canio, Andrea Trost, Lara Bieler, Pia Zaunmair, Peter Rotheneichner, Anna O’Sullivan, Sebastien Couillard-Despres, Oihana Errea, Maarja A. Mäe, Johanna Andrae, Liqun He, Annika Keller, Luis F. Bátiz, Christer Betsholtz, Ludwig Aigner, Robin J.M. Franklin, Francisco J. Rivera
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1755-1764 (2017)
The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. D
Externí odkaz:
https://doaj.org/article/4a4c8209548f4d78bf8a35c0c107082d
Autor:
Ilias Kazanis, Kimberley A. Evans, Evangelia Andreopoulou, Christina Dimitriou, Christos Koutsakis, Ragnhildur Thora Karadottir, Robin J.M. Franklin
Publikováno v:
Stem Cell Reports, Vol 8, Iss 3, Pp 685-700 (2017)
Two populations of oligodendrogenic progenitors co-exist within the corpus callosum (CC) of the adult mouse. Local, parenchymal oligodendrocyte progenitor cells (pOPCs) and progenitors generated in the subependymal zone (SEZ) cytogenic niche. pOPCs a
Externí odkaz:
https://doaj.org/article/1fdc4f82fb284b55a9bd60e3cb368722
Publikováno v:
Cell Reports, Vol 15, Iss 4, Pp 761-773 (2016)
Oligodendrocyte progenitors (OPs) arise from distinct ventral and dorsal domains within the ventricular germinal zones of the embryonic CNS. The functional significance, if any, of these different populations is not known. Using dual-color reporter m
Externí odkaz:
https://doaj.org/article/8ac4b0bfd03c44379b05cf8c20639c29
Autor:
Sarah Moyon, Jimmy L. Huynh, Dipankar Dutta, Fan Zhang, Dan Ma, Seungyeul Yoo, Rebecca Lawrence, Michael Wegner, Gareth R. John, Ben Emery, Catherine Lubetzki, Robin J.M. Franklin, Guoping Fan, Jun Zhu, Jeffrey L. Dupree, Patrizia Casaccia
Publikováno v:
Cell Reports, Vol 15, Iss 4, Pp 748-760 (2016)
Oligodendrocytes derive from progenitors (OPCs) through the interplay of epigenomic and transcriptional events. By integrating high-resolution methylomics, RNA-sequencing, and multiple transgenic lines, this study defines the role of DNMT1 in develop
Externí odkaz:
https://doaj.org/article/8481ec09136b4d40b21221a8736c1ff8
Autor:
Shaline V. Fazal, Clara Mutschler, Civia Z. Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo, Robin J.M. Franklin, Roger A. Barker, Kelly R. Monk, Benjamin J. Steventon, Michael P. Coleman, Jose A. Gomez-Sanchez, Peter Arthur-Farraj
SARM1 is a central regulator of programmed axon death and is required to initiate axon self-destruction after traumatic and toxic insults to the nervous system. Abnormal activation of this axon degeneration pathway is increasingly recognized as a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eb1fe267175f2f740304601c4e3b108
https://doi.org/10.1101/2022.12.08.519209
https://doi.org/10.1101/2022.12.08.519209
Autor:
Charles ffrench-Constant, David G. MacManus, Jonathan Stutters, Owen R Pearson, DT Chard, Baris Kanber, Edward Needham, Zoya Georgieva, Joanne L. Jones, David Rog, Alasdair Coles, Rebecca S. Samson, Claudia A. M. Wheeler-Kingshott, J William L Brown, Ferran Prados, Peter Connick, Andrew W. Michell, Siddharthan Chandran, James Overell, Daniel R. Altmann, Paul D Flynn, Robin J.M. Franklin, Nick G Cunniffe, Carla Moran
Publikováno v:
Brown, J W L, Cunniffe, N G, Prados, F, Kanber, B, Jones, J L, Needham, E, Georgieva, Z, Rog, D, Pearson, O R, Overell, J, Macmanus, D, Samson, R S, Stutters, J, Ffrench-constant, C, Gandini Wheeler-kingshott, C A M, Moran, C, Flynn, P D, Michell, A W, Franklin, R J M, Chandran, S, Altmann, D R, Chard, D T, Connick, P & Coles, A J 2021, ' Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study ', The Lancet Neurology, vol. 20, no. 9, pp. 709-720 . https://doi.org/10.1016/S1474-4422(21)00179-4
Summary Background Progressive disability in multiple sclerosis occurs because CNS axons degenerate as a late consequence of demyelination. In animals, retinoic acid receptor RXR-gamma agonists promote remyelination. We aimed to assess the safety and
Autor:
Christos Koutsakis, Christina Dimitriou, Paraskevi Kakouri, Asterios Arampatzis, Evangelia Andreopoulou, Sofia Oikonomou, Ilias Kazanis, Melina Patsonis, Michaela Kourla, Dimitrios Dimitrakopoulos, Robin J.M. Franklin, Freyja McClenahan, Rana-Tahir Rasool, Danai-Kassandra Meri
Publikováno v:
Stem Cell Reports
Summary Postnatal brain neural stem and progenitor cells (NSPCs) cluster in anatomically inaccessible stem cell niches, such as the subependymal zone (SEZ). Here, we describe a method for the isolation of NSPCs from live animals, which we term “mil
Autor:
Fernando F. Gonzalez, Amara Larpthaveesarp, Robin J.M. Franklin, Vien Nguyen, Srikirti Kodali, Manideep Chavali, Ginez A. Gonzalez, David H. Rowitch
Publikováno v:
Pediatric research, vol 90, iss 6
Pediatric research
Pediatric research
Background Neonatal stroke affects 1 in 2800 live births and is a major cause of neurological injury. The Sonic hedgehog (Shh) signaling pathway is critical for central nervous system (CNS) development and has neuroprotective and reparative effects i