Impact of COVID-19 restrictions on alcohol consumption behaviours

Autor: Emily O. C. Palmer, William Trender, Robin J. Tyacke, Adam Hampshire, Anne Lingford-Hughes

Publikováno v: BJPsych Open, Vol 7 (2021)

Background We aimed to evaluate how coronavirus (COVID-19) restrictions had altered individual's drinking behaviours, including consumption, hangover experiences, and motivations to drink, and changing levels of depression and anxiety. Method We con

Externí odkaz: https://doaj.org/article/0ec047c8dbb04f8c8b9b916ccddc68b4

Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals

Autor: Nicholas R. Livingston, Valeria Calsolaro, Rainer Hinz, Joseph Nowell, Sanara Raza, Steve Gentleman, Robin J. Tyacke, Jim Myers, Ashwin V. Venkataraman, Robert Perneczky, Roger N. Gunn, Eugenii A. Rabiner, Christine A. Parker, Philip S. Murphy, Paul B. Wren, David J. Nutt, Paul M. Matthews, Paul Edison

Publikováno v: Molecular psychiatry 27, 2019-2029 (2022). doi:10.1038/s41380-021-01429-y
Livingston, N R, Calsolaro, V, Hinz, R, Nowell, J, Raza, S, Gentleman, S, Tyacke, R J, Myers, J, Venkataraman, A V, Perneczky, R, Gunn, R N, Rabiner, E A, Parker, C A, Murphy, P S, Wren, P B, Nutt, D J, Matthews, P M & Edison, P 2022, ' Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals ', Molecular psychiatry . https://doi.org/10.1038/s41380-021-01429-y

Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer’s disease. We explored this in vivo using multimodal PET and MRI imaging. Twenty subjects (11 older, cognitively impaired pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6468b7bbd0d6203385a9a66bf7332276
https://doi.org/10.1038/s41380-021-01429-y

Astrogliosis in aging and Parkinson's disease dementia: a new clinical study with 11C-BU99008 PET

Autor: Mohamed A Mohamed, Zhou Zeng, Marta Gennaro, Nicholas P Lao-Kaim, Jim F M Myers, Valeria Calsolaro, Grazia Daniela Femminella, Robin J Tyacke, Antonio Martin-Bastida, Roger N Gunn, David J Nutt, Paul Edison, Paola Piccini, Andreas-Antonios Roussakis

The role of astrogliosis in the pathology of brain aging and neurodegenerative diseases has recently drawn great attention. Imidazoline-2 binding sites represent a possible target to map the distribution of reactive astrocytes. In this study, we use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e515489c2c71fef00d975810218ee3
https://hdl.handle.net/11588/905772

Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load

Autor: Cornelius K. Donat, David J. Nutt, Magdalena Sastre, Ashwin V. Venkataraman, Jim Myers, Valeria Calsolaro, Christine A. Parker, Paul M. Matthews, Zhen Fan, Grazia Daniela Femminella, Robin J. Tyacke, Paul Bryan Wren, Nicholas R Livingston, Rainer Hinz, Sandra Silva Guedes, Paul Edison, Robert Perneczky, Roger N. Gunn, Eugenii A. Rabiner, Philip S. Murphy, Steve M. Gentleman

Publikováno v: Calsolaro, V, Matthews, P M, Donat, C K, Livingston, N R, Femminella, G D, Guedes, S S, Myers, J, Fan, Z, Tyacke, R J, Venkataraman, A V, Perneczky, R, Gunn, R, Rabiner, E A, Gentleman, S, Parker, C A, Murphy, P S, Wren, P B, Hinz, R, Sastre, M, Nutt, D J & Edison, P 2021, ' Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load ', Molecular psychiatry . https://doi.org/10.1038/s41380-021-01193-z
Molecular psychiatry 26(10), 5848-5855 (2021). doi:10.1038/s41380-021-01193-z

11C-BU99008 is a novel positron emission tomography (PET) tracer that enables selective imaging of astrocyte reactivity in vivo. To explore astrocyte reactivity associated with Alzheimer’s disease, 11 older, cognitively impaired (CI) subjects and 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc52868d74bd9cf3c612cad87df19d31
https://www.research.manchester.ac.uk/portal/en/publications/astrocyte-reactivity-with-lateonset-cognitive-impairment-assessed-in-vivo-using-11cbu99008-pet-and-its-relationship-with-amyloid-load(5c4d2f0c-0e54-4620-8ec0-04dc7e769ce7).html

Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s disease: an in vivo11C-BU99008 PET study

Autor: Gennaro Pagano, George Dervenoulas, David J. Nutt, Roger N. Gunn, Marios Politis, Eugenii A. Rabiner, Jim Myers, Heather Wilson, Robin J. Tyacke, Sotirios Polychronis

Publikováno v: Wilson, H, Dervenoulas, G, Pagano, G, Tyacke, R J, Polychronis, S, Myers, J, Gunn, R N, Rabiner, E, Nutt, D & Politis, M 2019, ' Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson's disease : an in vivo11C-BU99008 PET study ', Brain, vol. 142, no. 10, pp. 3116-3128 . https://doi.org/10.1093/brain/awz260

Astroglia are multifunctional cells that regulate neuroinflammation and maintain homeostasis within the brain. Astroglial a-synuclein-positive cytoplasmic accumulations have been shown post-mortem in patients with Parkinson's disease and therefore as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca2366c813423e73a520603dc9f8205
https://doi.org/10.1093/brain/awz260