Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Robin J. Ruthenborg"'
Autor:
Justin Goodwin, Michael L. Neugent, Shin Yup Lee, Joshua H. Choe, Hyunsung Choi, Dana M. R. Jenkins, Robin J. Ruthenborg, Maddox W. Robinson, Ji Yun Jeong, Masaki Wake, Hajime Abe, Norihiko Takeda, Hiroko Endo, Masahiro Inoue, Zhenyu Xuan, Hyuntae Yoo, Min Chen, Jung-Mo Ahn, John D. Minna, Kristi L. Helke, Pankaj K. Singh, David B. Shackelford, Jung-whan Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Adenocarcinoma and squamous cell carcinoma are distinct subtypes of non-small cell lung cancer. Here, the authors show that increased glycolytic flux, via increased glucose transporter Glut1 expression, is a core metabolic feature of squamous cell ca
Externí odkaz:
https://doaj.org/article/978e7e9cf1334033ac7b7717d1595249
Autor:
Eun-Taex Oh, Jung-whan Kim, Joon Mee Kim, Soo Jung Kim, Jae-Seon Lee, Soon-Sun Hong, Justin Goodwin, Robin J. Ruthenborg, Myung Gu Jung, Hae-June Lee, Chul-Ho Lee, Eun Sung Park, Chulhee Kim, Heon Joo Park
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Elevated levels of the oxidoreductase NQO1 in tumours are associated with poor prognosis but how this contributes to cancer is poorly understood. Here, the authors find that NQO1 competes with PHD proteins, resulting in the stabilization of the hypox
Externí odkaz:
https://doaj.org/article/e04e3f0597364832b313a01704bb6a52
Publikováno v:
Hypoxia
In obesity, dysregulated metabolism and aberrant expansion of adipose tissue lead to the development of tissue hypoxia that plays an important role in contributing to obesity-associated metabolic disorders. Recent studies utilizing adipocyte-specific
Autor:
Hyunsung Choi, Joshua H. Choe, Masaki Wake, Hiroko Endo, Robin J. Ruthenborg, Min Chen, John D. Minna, Masahiro Inoue, Dana M. R. Jenkins, Jung Whan Kim, Ji Yun Jeong, Maddox W. Robinson, Norihiko Takeda, Pankaj K. Singh, David B. Shackelford, Hajime Abe, Hyuntae Yoo, Kristi L. Helke, Michael L. Neugent, Zhenyu Xuan, Jung-Mo Ahn, Justin Goodwin, Shin Yup Lee
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular and clinical presentation. However, metabolic signatures specific to indi
Publikováno v:
Molecules and Cells
Wound healing is a complex multi-step process that requires spatial and temporal orchestration of cellular and non-cellular components. Hypoxia is one of the prominent microenvironmental factors in tissue injury and wound healing. Hypoxic responses,
Autor:
Soo Jung Kim, Joon Mee Kim, Jae Seon Lee, Soon-Sun Hong, Myung Gu Jung, Chulhee Kim, Chul-Ho Lee, Robin J. Ruthenborg, Eun-Taex Oh, Eun Sung Park, Justin Goodwin, Hae June Lee, Jung Whan Kim, Heon Joo Park
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
NATURE COMMUNICATIONS(7)
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
NATURE COMMUNICATIONS(7)
Overexpression of NQO1 is associated with poor prognosis in human cancers including breast, colon, cervix, lung and pancreas. Yet, the molecular mechanisms underlying the pro-tumorigenic capacities of NQO1 have not been fully elucidated. Here we show