Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Robin J. Parks"'
Autor:
Charlotte A. René, Robin J. Parks
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101259- (2024)
Extracellular vesicles (EVs) have the innate ability to carry proteins, lipids, and nucleic acids between cells, and thus these vesicles have gained much attention as potential therapeutic delivery vehicles. Many strategies have been explored to enha
Externí odkaz:
https://doaj.org/article/8ec31dbd06434b5cb03a299bdbb36d5a
Autor:
Charlotte A. René, Robin J. Parks
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1764 (2023)
Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by mutations in the survival of motor neuron 1 (SMN1) gene, which leads to a reduced level in the SMN protein within cells. Patients with SMA suffer from a loss of alpha mot
Externí odkaz:
https://doaj.org/article/b8ce72cff56f406696813e1c141d2ace
Autor:
Morgan R. Jennings, Robin J. Parks
Publikováno v:
Viruses, Vol 15, Iss 1, p 161 (2023)
Human adenovirus (HAdV) is extremely common and can rapidly spread in confined populations such as daycare centers, hospitals, and retirement homes. Although HAdV usually causes only minor illness in otherwise healthy patients, HAdV can cause signifi
Externí odkaz:
https://doaj.org/article/d67363b5409f4b828fe558b64a4bd387
Oncolytic Rhabdovirus Vaccine Boosts Chimeric Anti-DEC205 Priming for Effective Cancer Immunotherapy
Autor:
Fanny Tzelepis, Harsimrat Kaur Birdi, Anna Jirovec, Silvia Boscardin, Christiano Tanese de Souza, Mohsen Hooshyar, Andrew Chen, Keara Sutherland, Robin J. Parks, Joel Werier, Jean-Simon Diallo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 19, Iss , Pp 240-252 (2020)
Prime-boost vaccination employing heterologous viral vectors encoding an antigen is an effective strategy to maximize the antigen-specific immune response. Replication-deficient adenovirus serotype 5 (Ad5) is currently being evaluated clinically in N
Externí odkaz:
https://doaj.org/article/85c0f1ffc30c4c7e93249fbf227e89f3
Publikováno v:
Molecular Therapy: Oncolytics, Vol 14, Iss , Pp 107-120 (2019)
Intratumoral injection of oncolytic viruses provides a direct means of tumor cell destruction for inoperable tumors. Unfortunately, oncolytic vectors based on human adenovirus (HAdV) typically do not spread efficiently throughout the tumor mass, redu
Externí odkaz:
https://doaj.org/article/9b4523ac63244b249bbc6b2426ea071b
Autor:
Yize Zhang, Chae Young Han, Fu Gang Duan, Xing-Xing Fan, Xiao-Jun Yao, Robin J. Parks, Yi-Jun Tang, Mei-Fang Wang, Liang Liu, Benjamin K. Tsang, Elaine Lai-Han Leung
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths primarily due to chemoresistance. Somatic mutation of TP53 (36%) and epidermal growth factor receptor (EGFR; > 30%) are major contributors to cisplatin (CDDP
Externí odkaz:
https://doaj.org/article/1ea23b3c0e6943e99cd10292b4172a84
Autor:
Meenakshi Sundaram, Kaitlin R. Curtis, Mohsen Amir Alipour, Nicholas D. LeBlond, Kaitlyn D. Margison, Rebecca A. Yaworski, Robin J. Parks, Adam D. McIntyre, Robert A. Hegele, Morgan D. Fullerton, Zemin Yao
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 11, Pp 2188-2196 (2017)
Recent cell culture and animal studies have suggested that expression of human apo C-III in the liver has a profound impact on the triacylglycerol (TAG)-rich VLDL1 production under lipid-rich conditions. The apoC-III Gln38Lys variant was identified i
Externí odkaz:
https://doaj.org/article/22d51921708541d59192f962d2353386
Autor:
Chae Young Han, David A. Patten, Se Ik Kim, Jung Jin Lim, David W. Chan, Michelle K. Y. Siu, Youngjin Han, Euridice Carmona, Robin J. Parks, Cheol Lee, Li-Jun Di, Zhen Lu, Karen K. L. Chan, Ja-Lok Ku, Elizabeth A. Macdonald, Barbara C. Vanderhyden, Anne-Marie Mes-Masson, Hextan Y. S. Ngan, Annie N. Y. Cheung, Yong Sang Song, Robert C. Bast, Mary-Ellen Harper, Benjamin K. Tsang
Publikováno v:
Cancers, Vol 13, Iss 14, p 3399 (2021)
In epithelial ovarian cancer (EOC), carboplatin/cisplatin-induced chemoresistance is a major hurdle to successful treatment. Aerobic glycolysis is a common characteristic of cancer. However, the role of glycolytic metabolism in chemoresistance and it
Externí odkaz:
https://doaj.org/article/963443b56ff34d7aa91c51ff9b5a764b
Autor:
Charlotte A. René, Robin J. Parks
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 492 (2021)
The central nervous system (CNS) is surrounded by the blood–brain barrier (BBB), a semipermeable border of endothelial cells that prevents pathogens, solutes and most molecules from non-selectively crossing into the CNS. Thus, the BBB acts to prote
Externí odkaz:
https://doaj.org/article/de49e44a07364831b0e7c0f155856667
Autor:
Matías Alvarez-Saavedra, Yves De Repentigny, Doo Yang, Ryan W. O’Meara, Keqin Yan, Lukas E. Hashem, Lemuel Racacho, Ilya Ioshikhes, Dennis E. Bulman, Robin J. Parks, Rashmi Kothary, David J. Picketts
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 862-875 (2016)
Exercise has been argued to enhance cognitive function and slow progressive neurodegenerative disease. Although exercise promotes neurogenesis, oligodendrogenesis and adaptive myelination are also significant contributors to brain repair and brain he
Externí odkaz:
https://doaj.org/article/9b6b65d29dbe477783fc4f4ada236722