Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Robin J. Goody"'
Autor:
Donnicia James, Anish Kurian, Chintan Patel, Lori-Ann Christie, Thomas C. Hohman, Wenzheng Hu, Matthew S Lawrence, Richard Torres, Robin J Goody
Publikováno v:
Exp Eye Res
The purpose of this study was to characterize and develop a primate model of chronic retinal neovascularization and vascular leakage that can be employed to assess efficacy of experimental therapeutics targeting retinal ischemic and neovascular disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a490ff26080236809ae0de0a348599af
https://europepmc.org/articles/PMC7335215/
https://europepmc.org/articles/PMC7335215/
Autor:
Afshin Shafiee, Robin J Goody, Stephen P. Bartels, Francisco J. López, Wenzheng Hu, Michael Struharik, Matthew S Lawrence
Publikováno v:
Experimental Eye Research. 92:464-472
We developed and validated a new nonhuman primate model of laser-induced choroidal neovascularization (CNV) that addresses study design limitations prevalent in laser-induced CNV-based efficacy studies. Laser-induced Bruch’s membrane disruption tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b209bdb4d4c5eeac9485cb17cc8b5909
https://doi.org/10.1016/j.exer.2011.03.006
https://doi.org/10.1016/j.exer.2011.03.006
Publikováno v:
Journal of Medical Primatology. 39:389-398
Background Hematology and clinical chemistry (HCC) reference values are critical in veterinary practice and in vivo pre-clinical research, enabling detection of health abnormalities, response to therapeutic intervention or adverse toxicological effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a34dbff7fa885ab9eb0ee26a2d47d6c3
https://doi.org/10.1111/j.1600-0684.2010.00422.x
https://doi.org/10.1111/j.1600-0684.2010.00422.x
Publikováno v:
Journal of Neurovirology. 13:373-383
Reovirus infection provides a classic experimental model system for studying the pathogenesis of viral infections of the central nervous system (CNS), with apoptosis acting as the major mechanism of cell death. The authors have examined the role of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7d92ade33865ab415fb6bb233d3788
https://doi.org/10.1080/13550280701344983
https://doi.org/10.1080/13550280701344983
Publikováno v:
Neurology. 66:361-365
To provide a large, comprehensive evaluation of the CSF findings in patients with serologically confirmed West Nile virus (WNV), CNS disease, and their correlation with outcome.CSF samples from 334 WNV-infected hospitalized patients were analyzed. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58aab6ad4bbb3f27dc97b6abf8079d9
https://doi.org/10.1212/01.wnl.0000195890.70898.1f
https://doi.org/10.1212/01.wnl.0000195890.70898.1f
Publikováno v:
Experimental Neurology. 195:379-390
Nitric oxide (NO) has been implicated as a contributor to the host's innate defense against viral infections including those affecting the CNS. Reovirus infection of the CNS is a classic experimental system for understanding the pathogenesis of neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc725ba1903a5ab206695d61ffc89304
https://doi.org/10.1016/j.expneurol.2005.05.016
https://doi.org/10.1016/j.expneurol.2005.05.016
Autor:
Indrapal N. Singh, Pamela E. Knapp, Robin J. Goody, Sarah E. Lutz, Kurt F. Hauser, Nael M Ahmad, Avindra Nath, Celeste Dean
Publikováno v:
Journal of Neurovirology. 10:141-151
Human immunodeficiency virus-1 (HIV-1) infection affects the striatum, resulting in gliosis and neuronal losses. To determine whether HIV-1 proteins induce striatal neurotoxicity through an apoptotic mechanism, mouse striatal neurons isolated on embr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d6a52fdc0626d142cbf0ec7ee22c1c
https://doi.org/10.1080/13550280490441103
https://doi.org/10.1080/13550280490441103
Publikováno v:
Neuroscience. 116:807-816
Dynorphin A (1-17) is an endogenous opioid peptide that is antinociceptive at physiological concentrations, but in excess can elicit a number of pathological effects. Both κ-opioid and N -methyl- d -aspartate receptor antagonists modulate dynorphin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0339f14320cd476fbfef5c1a1f1182
https://doi.org/10.1016/s0306-4522(02)00563-8
https://doi.org/10.1016/s0306-4522(02)00563-8
Autor:
Anders M. Näär, Steve Henry, Johnathan R. Whetstine, Raymond T. Chung, Robert E. Gerszten, Seyed Hani Najafi-Shoushtari, Robin J Goody, Susanna Obad, Andrew deLemos, Rohn Brookes, Steve Whittaker, Matthew Lawrence, Joshua C. Black, Sumita Sinha, Robert W. McGarrah, Henrik Frydenlund Hansen, Veerle Rottiers, Andreas Petri, Marie Lindholm, Sakari Kauppinen
Publikováno v:
Rottiers, V, Obad, S, Petri, A, McGarrah, R, Lindholm, M W, Black, J C, Sinha, S, Goody, R J, Lawrence, M S, Delemos, A S, Hansen, H F, Whittaker, S, Henry, S, Brookes, R, Najafi-Shoushtari, S H, Chung, R T, Whetstine, J R, Gerszten, R E, Kauppinen, S & Näär, A M 2013, ' Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR ', Science Translational Medicine, vol. 5, no. 212, pp. 212ra162 . https://doi.org/10.1126/scitranslmed.3006840
MicroRNAs (miRNAs) regulate many aspects of human biology. They target mRNAs for translational repression or degradation through base-pairing with 3’ UTRs, primarily via seed sequences (nucleotides 2-8 in the mature miRNA sequence). A number of ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aad12278fa954b88f6db17e9a7b5e1a
https://pubmed.ncbi.nlm.nih.gov/24259050
https://pubmed.ncbi.nlm.nih.gov/24259050
Autor:
Salman Al-Mahmood, Stéphanie Lamoureux, Robin J Goody, Frank Cloutier, Patricia Udaondo, Eric Thorin, Jean-Pascal Conduzorgues, Amel Hadri, Sylvie Colin, Sylvain Chemtob, Eric Viaud, Claus Cursiefen, Antoine Ferry, Matthew Lawrence
Publikováno v:
Investigative ophthalmologyvisual science. 53(3)
PURPOSE. Aganirsen, an antisense oligonucleotide inhibiting insulin receptor substrate (IRS)-1 expression, has been shown to promote the regression of pathologic corneal neovascularization in patients. In this study, the authors aimed to demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9e433e7a0071b63bd4d5ad10be94df
https://pubmed.ncbi.nlm.nih.gov/22323484
https://pubmed.ncbi.nlm.nih.gov/22323484