Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Robin J. Dickinson"'
Autor:
Almudena Sacristán-Reviriego, Robin J. Dickinson, Mark P. Didmon, María Molina, Humberto Martín, Lorena Palacios, Stephen M. Keyse, María José Marín
Publikováno v:
The Journal of Biological Chemistry
Background: Dual specificity protein phosphatases (DSPs) bind MAPKs through specific interaction motifs. Results: A novel motif (IYT) in Msg5 mediates a common docking domain-independent interaction with the yeast cell integrity kinase Slt2. Conclusi
Autor:
Christopher J. Staples, Maria Ekerot, Marios P. Stavridis, Iain D. Keenan, Robin J. Dickinson, David M. Owens, Stephen M. Keyse, Laurent Delavaine, Michael Mitchell, Kate G. Storey
Publikováno v:
Biochemical Journal
DUSP6 (dual-specificity phosphatase 6), also known as MKP-3 [MAPK (mitogen-activated protein kinase) phosphatase-3] specifically inactivates ERK1/2 (extracellular-signal-regulated kinase 1/2) in vitro and in vivo. DUSP6/MKP-3 is inducible by FGF (fib
Autor:
M. Shafiq, M. Collister, Nick Totty, Robin J. Dickinson, Gavin C. Fox, David Briggs, Sarah Hanrahan, Stephen M. Keyse, Michael J. R. Stark, Neil Q. McDonald, Vasso Makrantoni, Philip P. Knowles, M. J. Didmon
Publikováno v:
Nature. 447:487-492
The stress-induced yeast MAPK phosphatase Sdp1 acquires enhanced activity under oxidative conditions by forming an intramolecular disulphide bond that is used to recognize a tyrosine-phosphorylated substrate. Reactive oxygen species trigger cellular
Autor:
Stephen M. Keyse, Robin J. Dickinson
Publikováno v:
Journal of Cell Science. 119:4607-4615
A structurally distinct subfamily of ten dual-specificity (Thr/Tyr) protein phosphatases is responsible for the regulated dephosphorylation and inactivation of mitogen-activated protein kinase (MAPK) family members in mammals. These MAPK phosphatases
Publikováno v:
Journal of Biological Chemistry. 279:41882-41891
MAP kinase phosphatase (MKP)-3 is a cytoplasmic dual specificity protein phosphatase that specifically binds to and inactivates the ERK1/2 MAP kinases in mammalian cells. However, the molecular basis of the cytoplasmic localization of MKP-3 or its ph
Autor:
Kate G. Storey, Elizabeth R. Farrell, J. Simon Lunn, Cheryll Tickle, Maxwell C. Eblaghie, Robin J. Dickinson, Juan Jose Sanz-Ezquerro, Joanne Mathers, Andrea Münsterberg, Stephen M. Keyse
Publikováno v:
Current Biology. 13:1009-1018
Background: The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in cultured mammalian cells that Pyst1/MKP3, a dual specificity protein phosphatase, specificall
Autor:
Ole Morten Seternes, David N. Slack, Robin J. Dickinson, David J. Williams, Stephen M. Keyse, Jill Williamson
Publikováno v:
Biochemical Journal. 364:145-155
Mitogen-activated protein kinases (MAPKs) play a vital role in cellular growth control, but far less is known about these signalling pathways in the context of embryonic development. Duration and magnitude of MAPK activation are crucial factors in ce
Autor:
Ursula Boschert, Emilio Merlo Pich, Caterina Bendotti, Celestine O'Shaughnessy, Robin J. Dickinson, Stefan Catsicas, Michela Tessari
Publikováno v:
The Journal of Comparative Neurology. 367:177-193
In this article we study the relationship between the expression pattern of two recently identified isoforms of the 25-kD synaptosomal-associated protein (SNAP-25a and SNAP-25b) and the morphological changes inherent to neuronal plasticity during dev
Autor:
Ursula Boschert, Montserrat Camps, Marco Muda, Isabelle Martinou, Werner Schlegel, Jean-Claude Martinou, Robin J. Dickinson, Steve Arkinstall
Publikováno v:
Journal of Biological Chemistry. 271:4319-4326
MKP-1 (also known as CL100, 3CH134, Erp, and hVH-1) exemplifies a class of dual-specificity phosphatase able to reverse the activation of mitogen-activated protein (MAP) kinase family members by dephosphorylating critical tyrosine and threonine resid
Autor:
Graeme Stewart, Robin J. Dickinson, Rachael Rutkowski, Stephen M. Keyse, Marianne Schimpl, Anton Gartner, Ashley L. Craig
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 7, Iss 8, p e1002238 (2011)
PLoS Genetics, Vol 7, Iss 8, p e1002238 (2011)
Maintaining genome stability in the germline is thought to be an evolutionarily ancient role of the p53 family. The sole Caenorhabditis elegans p53 family member CEP-1 is required for apoptosis induction in meiotic, late-stage pachytene germ cells in