Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Robin J Tyacke"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9787 (2023)
Targeting neuroinflammation, and in particular, microglial activation and astrocytosis, is a current area of the focus of new treatment interventions for a number of neurodegenerative disorders. Probing the roles of microglia and astrocytes in human
Externí odkaz:
https://doaj.org/article/17c1868452db4846ae91abf61f341fcd
Publikováno v:
BJPsych Open, Vol 7 (2021)
Background We aimed to evaluate how coronavirus (COVID-19) restrictions had altered individual's drinking behaviours, including consumption, hangover experiences, and motivations to drink, and changing levels of depression and anxiety. Method We con
Externí odkaz:
https://doaj.org/article/0ec047c8dbb04f8c8b9b916ccddc68b4
Autor:
David J. Nutt, Robin J. Tyacke, Meg Spriggs, Vanessa Jacoby, Alan D. Borthwick, Delia Belelli
Publikováno v:
Nutrients, Vol 14, Iss 18, p 3761 (2022)
The consumption of alcohol is associated with well-known health harms and many governments worldwide are actively engaged in devising approaches to reduce them. To this end, a common proposed strategy aims at reducing alcohol consumption. This approa
Externí odkaz:
https://doaj.org/article/29bf56563d5540eab844afad611918b0
Autor:
Ashwin V. Venkataraman, Nicholas Keat, James F. Myers, Samuel Turton, Inge Mick, Roger N. Gunn, Eugenii A. Rabiner, Jan Passchier, Christine A. Parker, Robin J. Tyacke, David J. Nutt
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-7 (2018)
Abstract Background We measured whole body distribution of 11C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline2 binding site. The purpose of this phase I study was to evaluate the biodistribution and radiation dosimetr
Externí odkaz:
https://doaj.org/article/0063b94551df472fbb9998d94ab821a5
Autor:
Nicholas R. Livingston, Valeria Calsolaro, Rainer Hinz, Joseph Nowell, Sanara Raza, Steve Gentleman, Robin J. Tyacke, Jim Myers, Ashwin V. Venkataraman, Robert Perneczky, Roger N. Gunn, Eugenii A. Rabiner, Christine A. Parker, Philip S. Murphy, Paul B. Wren, David J. Nutt, Paul M. Matthews, Paul Edison
Publikováno v:
Molecular psychiatry 27, 2019-2029 (2022). doi:10.1038/s41380-021-01429-y
Livingston, N R, Calsolaro, V, Hinz, R, Nowell, J, Raza, S, Gentleman, S, Tyacke, R J, Myers, J, Venkataraman, A V, Perneczky, R, Gunn, R N, Rabiner, E A, Parker, C A, Murphy, P S, Wren, P B, Nutt, D J, Matthews, P M & Edison, P 2022, ' Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals ', Molecular psychiatry . https://doi.org/10.1038/s41380-021-01429-y
Livingston, N R, Calsolaro, V, Hinz, R, Nowell, J, Raza, S, Gentleman, S, Tyacke, R J, Myers, J, Venkataraman, A V, Perneczky, R, Gunn, R N, Rabiner, E A, Parker, C A, Murphy, P S, Wren, P B, Nutt, D J, Matthews, P M & Edison, P 2022, ' Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals ', Molecular psychiatry . https://doi.org/10.1038/s41380-021-01429-y
Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer’s disease. We explored this in vivo using multimodal PET and MRI imaging. Twenty subjects (11 older, cognitively impaired pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6468b7bbd0d6203385a9a66bf7332276
https://doi.org/10.1038/s41380-021-01429-y
https://doi.org/10.1038/s41380-021-01429-y
Autor:
Mohamed A Mohamed, Zhou Zeng, Marta Gennaro, Nicholas P Lao-Kaim, Jim F M Myers, Valeria Calsolaro, Grazia Daniela Femminella, Robin J Tyacke, Antonio Martin-Bastida, Roger N Gunn, David J Nutt, Paul Edison, Paola Piccini, Andreas-Antonios Roussakis
The role of astrogliosis in the pathology of brain aging and neurodegenerative diseases has recently drawn great attention. Imidazoline-2 binding sites represent a possible target to map the distribution of reactive astrocytes. In this study, we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e515489c2c71fef00d975810218ee3
https://hdl.handle.net/11588/905772
https://hdl.handle.net/11588/905772
Autor:
Steve M. Gentleman, Jim Myers, Paul Edison, David J. Nutt, Paul M. Matthews, Robin J. Tyacke, Nicholas R Livingston, Sanara Raza, Robert Perneczky, Joseph Nowell, Paul Bryan Wren, Roger N. Gunn, Ashwin V. Venkataraman, Valeria Calsolaro, Rainer Hinz, Eugenii A. Rabiner, Philip S. Murphy, Christine A. Parker
Post mortemneuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer’s disease. We explored thisin vivousing multimodal PET and MRI imaging. Twenty subjects (11 older, cognitively impaired subje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63eaa10956651dba8924b35fd70226eb
https://doi.org/10.1101/2021.08.10.21261690
https://doi.org/10.1101/2021.08.10.21261690
Autor:
Cornelius K. Donat, David J. Nutt, Magdalena Sastre, Ashwin V. Venkataraman, Jim Myers, Valeria Calsolaro, Christine A. Parker, Paul M. Matthews, Zhen Fan, Grazia Daniela Femminella, Robin J. Tyacke, Paul Bryan Wren, Nicholas R Livingston, Rainer Hinz, Sandra Silva Guedes, Paul Edison, Robert Perneczky, Roger N. Gunn, Eugenii A. Rabiner, Philip S. Murphy, Steve M. Gentleman
Publikováno v:
Calsolaro, V, Matthews, P M, Donat, C K, Livingston, N R, Femminella, G D, Guedes, S S, Myers, J, Fan, Z, Tyacke, R J, Venkataraman, A V, Perneczky, R, Gunn, R, Rabiner, E A, Gentleman, S, Parker, C A, Murphy, P S, Wren, P B, Hinz, R, Sastre, M, Nutt, D J & Edison, P 2021, ' Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load ', Molecular psychiatry . https://doi.org/10.1038/s41380-021-01193-z
Molecular psychiatry 26(10), 5848-5855 (2021). doi:10.1038/s41380-021-01193-z
Molecular psychiatry 26(10), 5848-5855 (2021). doi:10.1038/s41380-021-01193-z
11C-BU99008 is a novel positron emission tomography (PET) tracer that enables selective imaging of astrocyte reactivity in vivo. To explore astrocyte reactivity associated with Alzheimer’s disease, 11 older, cognitively impaired (CI) subjects and 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc52868d74bd9cf3c612cad87df19d31
https://www.research.manchester.ac.uk/portal/en/publications/astrocyte-reactivity-with-lateonset-cognitive-impairment-assessed-in-vivo-using-11cbu99008-pet-and-its-relationship-with-amyloid-load(5c4d2f0c-0e54-4620-8ec0-04dc7e769ce7).html
https://www.research.manchester.ac.uk/portal/en/publications/astrocyte-reactivity-with-lateonset-cognitive-impairment-assessed-in-vivo-using-11cbu99008-pet-and-its-relationship-with-amyloid-load(5c4d2f0c-0e54-4620-8ec0-04dc7e769ce7).html
Autor:
Nicholas R, Livingston, Valeria, Calsolaro, Rainer, Hinz, Joseph, Nowell, Sanara, Raza, Steve, Gentleman, Robin J, Tyacke, Jim, Myers, Ashwin V, Venkataraman, Robert, Perneczky, Roger N, Gunn, Eugenii A, Rabiner, Christine A, Parker, Philip S, Murphy, Paul B, Wren, David J, Nutt, Paul M, Matthews, Paul, Edison
Publikováno v:
Molecular psychiatry. 27(4)
Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer's disease. We explored this in vivo using multimodal PET and MRI imaging. Twenty subjects (11 older, cognitively impaired pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed03030eb219a48f6f313de2c6bb6455
https://pubmed.ncbi.nlm.nih.gov/35125495
https://pubmed.ncbi.nlm.nih.gov/35125495
Autor:
Gennaro Pagano, George Dervenoulas, David J. Nutt, Roger N. Gunn, Marios Politis, Eugenii A. Rabiner, Jim Myers, Heather Wilson, Robin J. Tyacke, Sotirios Polychronis
Publikováno v:
Wilson, H, Dervenoulas, G, Pagano, G, Tyacke, R J, Polychronis, S, Myers, J, Gunn, R N, Rabiner, E, Nutt, D & Politis, M 2019, ' Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson's disease : an in vivo11C-BU99008 PET study ', Brain, vol. 142, no. 10, pp. 3116-3128 . https://doi.org/10.1093/brain/awz260
Astroglia are multifunctional cells that regulate neuroinflammation and maintain homeostasis within the brain. Astroglial a-synuclein-positive cytoplasmic accumulations have been shown post-mortem in patients with Parkinson's disease and therefore as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca2366c813423e73a520603dc9f8205
https://doi.org/10.1093/brain/awz260
https://doi.org/10.1093/brain/awz260