Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Robin J McAnulty"'
Autor:
Maria D. I. Manunta, Aristides D. Tagalakis, Martin Attwood, Ahmad M. Aldossary, Josephine L. Barnes, Mustafa M. Munye, Alexander Weng, Robin J McAnulty, Stephen L. Hart
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and mucociliary function. The challenge has been to deliver siRNA to the
Externí odkaz:
https://doaj.org/article/e1dcd0da9f604c4c97453b6b34085cf2
Autor:
Maria D I Manunta, Robin J McAnulty, Aristides D Tagalakis, Stephen E Bottoms, Frederick Campbell, Helen C Hailes, Alethea B Tabor, Geoffrey J Laurent, Christopher O'Callaghan, Stephen L Hart
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26768 (2011)
Gene therapy mediated by synthetic vectors may provide opportunities for new treatments for cystic fibrosis (CF) via aerosolisation. Vectors for CF must transfect the airway epithelium efficiently and not cause inflammation so they are suitable for r
Externí odkaz:
https://doaj.org/article/b4e704dda6444ec3ac8d0e904dd593d2
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9674 (2010)
The TGF-beta family of mediators are thought to play important roles in the regulation of inflammation and airway remodelling in asthma. All three mammalian isoforms of TGF-beta, TGF-beta(1-3), are expressed in the airways and TGF-beta(1) and -beta(2
Externí odkaz:
https://doaj.org/article/56ced0fde23140a2a144511a453a7052
Autor:
Beatriz Guillen-Guio, Megan L. Paynton, Richard J. Allen, Daniel P.W. Chin, Lauren J. Donoghue, Amy Stockwell, Olivia C. Leavy, Tamara Hernandez-Beeftink, Carl Reynolds, Paul Cullinan, Fernando Martinez, Helen L. Booth, William A. Fahy, Ian P. Hall, Simon P. Hart, Mike R. Hill, Nik Hirani, Richard B. Hubbard, Robin J. McAnulty, Ann B. Millar, Vidya Navaratnam, Eunice Oballa, Helen Parfrey, Gauri Saini, Ian Sayers, Martin D. Tobin, Moira K.B. Whyte, Ayodeji Adegunsoye, Naftali Kaminski, Shwu-Fan Ma, Mary E. Strek, Yingze Zhang, Tasha E. Fingerlin, Maria Molina-Molina, Margaret Neighbors, X. Rebecca Sheng, Justin M. Oldham, Toby M. Maher, Philip L. Molyneaux, Carlos Flores, Imre Noth, David A. Schwartz, Brian L. Yaspan, R. Gisli Jenkins, Louise V. Wain, Edward J. Hollox
Publikováno v:
ERJ Open Research, Vol 10, Iss 1 (2024)
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the potential role of infection in the pathogenesis of IPF, and a prior ass
Externí odkaz:
https://doaj.org/article/473a7531d84a4f018fe7880dc13a5162
Autor:
Cecilia M. Prêle, Tylah Miles, David R. Pearce, Robert J. O'Donoghue, Chris Grainge, Lucy Barrett, Kimberly Birnie, Andrew D. Lucas, Svetlana Baltic, Matthias Ernst, Catherine Rinaldi, Geoffrey J. Laurent, Darryl A. Knight, Mark Fear, Gerard Hoyne, Robin J. McAnulty, Steven E. Mutsaers
Publikováno v:
European Respiratory Journal. 60:2101469
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease associated with chronic inflammation and tissue remodelling leading to fibrosis, reduced pulmonary function, respiratory failure and death. Bleomycin (Blm)-induced lung fibrosis in m
Autor:
Geoffrey J. Laurent, Philip J. Thompson, David R. Pearce, Sarra E. Jamieson, Matthias Ernst, Tylah Miles, Cecilia M Prêle, Robin J. McAnulty, Darryl A. Knight, Bahareh Badrian, Steven E. Mutsaers, Thomas Iosifidis
Publikováno v:
Biomedicines, Vol 9, Iss 498, p 498 (2021)
Biomedicines
Volume 9
Issue 5
Biomedicines
Volume 9
Issue 5
The interleukin (IL)-6 family of cytokines and exaggerated signal transducer and activator of transcription (STAT)3 signaling is implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis, but the mechanisms regulating STAT3 expression and functi
Autor:
Simon P. Hart, Vilmundur Gudnason, Yingze Zhang, Hiroto Hatabu, Rebecca Braybrooke, R. Gisli Jenkins, Shwu-Fan Ma, Michael Ng, Carlos Flores, George T. O'Connor, Ma'en Obeidat, Nik Hirani, Brian D. Hobbs, Megan L. Paynton, Amy Dressen, Ayodeji Adegunsoye, Helen Booth, Dominic Furniss, Philippe Joubert, Eunice Oballa, Ian Sayers, Martin D. Tobin, Krina T. Zondervan, Richard Hubbard, Xuan Li, Yohan Bossé, John D. Newell, Beatriz Guillen-Guio, Ann B. Millar, Wim Timens, Mary E. Strek, Gunnar Gudmundsson, Philip L. Molyneaux, Gary M. Hunninghake, Ani Manichaikul, Tasha E. Fingerlin, Rachel K. Putman, Richard J. Allen, Vidyia Navaratnam, Maria Molina-Molina, Don D. Sin, Helen Parfrey, Luke M. Kraven, Moira K. B. Whyte, Xuting R. Sheng, Phuwanat Sakornsakolpat, David J. Lederer, David C. Nickle, Ian P. Hall, Brian L. Yaspan, Louise V. Wain, Toby M. Maher, Gauri Saini, Ke Hao, Michael Hill, Naftali Kaminski, Andrew P. Morris, Hanfei Xu, Justin M. Oldham, David A. Schwartz, Robin J. McAnulty, Michael H. Cho, Victor E. Ortega, Margaret Neighbors, Imre Noth, William A. Fahy
Publikováno v:
Allen, R J, Guillen-guio, B, Oldham, J M, Ma, S, Dressen, A, Paynton, M L, Kraven, L M, Obeidat, M, Li, X, Ng, M, Braybrooke, R, Molina-molina, M, Hobbs, B D, Putman, R K, Sakornsakolpat, P, Booth, H L, Fahy, W A, Hart, S P, Hill, M R, Hirani, N, Hubbard, R B, Mcanulty, R J, Millar, A B, Navaratnam, V, Oballa, E, Parfrey, H, Saini, G, Whyte, M K B, Zhang, Y, Kaminski, N, Adegunsoye, A, Strek, M E, Neighbors, M, Sheng, X R, Gudmundsson, G, Gudnason, V, Hatabu, H, Lederer, D J, Manichaikul, A, Newell Jr., J D, O'connor, G T, Ortega, V E, Xu, H, Fingerlin, T E, Bossé, Y, Hao, K, Joubert, P, Nickle, D C, Sin, D D, Timens, W, Furniss, D, Morris, A P, Zondervan, K, Hall, I P, Sayers, I, Tobin, M D, Maher, T M, Cho, M H, Hunninghake, G M, Schwartz, D A, Yaspan, B L, Molyneaux, P L, Flores, C, Noth, I, Jenkins, R G & Wain, L V 2020, ' Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis ', American Journal of Respiratory and Critical Care Medicine, vol. 201, no. 5, pp. 564-574 . https://doi.org/10.1164/rccm.201905-1017OC
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
American Journal of Respiratory and Critical Care Medicine, 201(5), 564-574. AMER THORACIC SOC
Allen, R J, Guillen-Guio, B, Oldham, J M, Ma, S-F, Dressen, A, Paynton, M L, Kraven, L M, Obeidat, M, Li, X, Ng, M, Braybrooke, R, Molina-Molina, M, Hobbs, B D, Putman, R K, Sakornsakolpat, P, Booth, H L, Fahy, W A, Hart, S P, Hill, M R, Hirani, N, Hubbard, R B, McAnulty, R J, Millar, A B, Navaratnam, V, Oballa, E, Parfrey, H, Saini, G, Whyte, M K B, Zhang, Y, Kaminski, N, Adegunsoye, A, Strek, M E, Neighbors, M, Sheng, X R, Gudmundsson, G, Gudnason, V, Hatabu, H, Lederer, D J, Manichaikul, A, Newell, J D, O'Connor, G T, Ortega, V E, Xu, H, Fingerlin, T E, Bossé, Y, Hao, K, Joubert, P, Nickle, D C, Sin, D D, Timens, W, Furniss, D, Morris, A P, Zondervan, K, Hall, I P, Sayers, I, Tobin, M D, Maher, T M, Cho, M H, Hunninghake, G M, Schwartz, D A, Yaspan, B L, Molyneaux, P L, Flores, C, Noth, I, Jenkins, R G & Wain, L V 2019, ' Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.201905-1017OC
American Journal of Respiratory and Critical Care Medicine
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
American Journal of Respiratory and Critical Care Medicine, 201(5), 564-574. AMER THORACIC SOC
Allen, R J, Guillen-Guio, B, Oldham, J M, Ma, S-F, Dressen, A, Paynton, M L, Kraven, L M, Obeidat, M, Li, X, Ng, M, Braybrooke, R, Molina-Molina, M, Hobbs, B D, Putman, R K, Sakornsakolpat, P, Booth, H L, Fahy, W A, Hart, S P, Hill, M R, Hirani, N, Hubbard, R B, McAnulty, R J, Millar, A B, Navaratnam, V, Oballa, E, Parfrey, H, Saini, G, Whyte, M K B, Zhang, Y, Kaminski, N, Adegunsoye, A, Strek, M E, Neighbors, M, Sheng, X R, Gudmundsson, G, Gudnason, V, Hatabu, H, Lederer, D J, Manichaikul, A, Newell, J D, O'Connor, G T, Ortega, V E, Xu, H, Fingerlin, T E, Bossé, Y, Hao, K, Joubert, P, Nickle, D C, Sin, D D, Timens, W, Furniss, D, Morris, A P, Zondervan, K, Hall, I P, Sayers, I, Tobin, M D, Maher, T M, Cho, M H, Hunninghake, G M, Schwartz, D A, Yaspan, B L, Molyneaux, P L, Flores, C, Noth, I, Jenkins, R G & Wain, L V 2019, ' Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.201905-1017OC
American Journal of Respiratory and Critical Care Medicine
Publisher's version (útgefin grein)
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide ass
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f735d247fb5068243ea799597c642afa
https://www.research.manchester.ac.uk/portal/en/publications/genomewide-association-study-of-susceptibility-to-idiopathic-pulmonary-fibrosis(6fbf4813-b9fe-4644-bec4-7b50df3d4de2).html
https://www.research.manchester.ac.uk/portal/en/publications/genomewide-association-study-of-susceptibility-to-idiopathic-pulmonary-fibrosis(6fbf4813-b9fe-4644-bec4-7b50df3d4de2).html
Autor:
George T. O'Connor, Gauri Saini, Helen Booth, Dominic Furniss, William A. Fahy, Ke Hao, Beatriz Guillen-Guio, Vilmundur Gudnason, Brian L. Yaspan, Imre Noth, Hanfei Xu, Hiroto Hatabu, Brian D. Hobbs, Ma'en Obeidat, Nik Hirani, Justin M. Oldham, Victor E. Ortega, David A. Schwartz, Simon P. Hart, Ani Manichaikul, Richard Hubbard, Xuan Li, Philippe Joubert, Michael Hill, Michael Ng, Ann B. Millar, Vidyia Navaratnam, Richard J. Allen, Rebecca Braybrooke, Ian Sayers, Ian P. Hall, Shwu-Fan Ma, Philip L. Molyneaux, Carlos Flores, Tasha E. Fingerlin, Martin D. Tobin, Gunnar Gudmundsson, Rachel K. Putman, Gary M. Hunninghake, Krina T. Zondervan, Moira K. B. Whyte, Robin J. McAnulty, Louise V. Wain, Andrew P. Morris, Michael H. Cho, David C. Nickle, Don D. Sin, Helen Parfrey, Toby M. Maher, Yohan Bossé, Maria Molina-Molina, John D. Newell, Eunice Oballa, Phuwanat Sakornsakolpat, David J. Lederer, R. Gisli Jenkins, Amy Dressen, Wim Timens, Luke M. Kraven, Megan L. Paynton
RationaleIdiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. The mechanisms by which this arises are poorly understood a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d678399307d65e16ef54c3cdc669cd0
https://doi.org/10.1101/636761
https://doi.org/10.1101/636761
Autor:
Michael Wood, Bruce W. S. Robinson, Keith S. Abayasiriwardana, Kimberly A Birnie, Geoffrey J. Laurent, Robin J. McAnulty, Steven E. Mutsaers, Cecilia M. Prêle
Publikováno v:
Biochemical and biophysical research communications. 510(2)
Malignant mesothelioma is an aggressive fibrous tumor, predominantly of the pleura, with a very poor prognosis. Cell-matrix interactions are recognized important determinants of tumor growth and invasiveness but the role of the extracellular matrix i
Autor:
EJ Forty, Pascal F. Durrenberger, Rachel C. Chambers, Robin J. McAnulty, Paul F. Mercer, S Tan
Publikováno v:
Cellular insights into lung injury repair.
Introduction Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease, with a poor prognosis and a lack of therapeutic options that halt disease progression. While the aetiology of IPF is unknown, dysregulated epitheli