Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Robin J M, Franklin"'
Autor:
Laura J. Wagstaff, Nadine Bestard-Cuche, Maja Kaczmarek, Antonella Fidanza, Lorraine McNeil, Robin J. M. Franklin, Anna C. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract In Multiple Sclerosis (MS), inflammatory demyelinated lesions in the brain and spinal cord lead to neurodegeneration and progressive disability. Remyelination can restore fast saltatory conduction and neuroprotection but is inefficient in MS
Externí odkaz:
https://doaj.org/article/7184d2b1e55348b98f2a48442e934e12
Autor:
Alerie Guzman de la Fuente, Marie Dittmer, Elise J. Heesbeen, Nira de la Vega Gallardo, Jessica A. White, Andrew Young, Tiree McColgan, Amy Dashwood, Katie Mayne, Sonia Cabeza-Fernández, John Falconer, Francisco Javier Rodriguez-Baena, Christopher E. McMurran, Mohammed Inayatullah, Khalil S. Rawji, Robin J. M. Franklin, James Dooley, Adrian Liston, Rebecca J. Ingram, Vijay K. Tiwari, Rosana Penalva, Yvonne Dombrowski, Denise C. Fitzgerald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. Regulatory T cells (Treg) recently emerged as critical players in
Externí odkaz:
https://doaj.org/article/f70bb2debb2f424cb592cce6e9b75195
Autor:
Christopher E. McMurran, Trisha Mukherjee, J William L. Brown, Andrew W. Michell, Declan T. Chard, Robin J. M. Franklin, Alasdair J. Coles, Nick G. Cunniffe
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 7, Pp 1090-1094 (2022)
Abstract Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that bexarotene, a putatively remyelinating retinoid‐X receptor agonist, shortened th
Externí odkaz:
https://doaj.org/article/6d0c103b90e94d1d9986fb871abf220e
Autor:
Shaline V. Fazal, Clara Mutschler, Civia Z. Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Ibañez-Grau, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo, Robin J. M. Franklin, Roger A. Barker, Kelly R. Monk, Benjamin J. Steventon, Michael P. Coleman, Jose A. Gomez-Sanchez, Peter Arthur-Farraj
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in a variety of disorders of the peripheral (PNS) and central nervous system (CNS). While SARM1
Externí odkaz:
https://doaj.org/article/11212149181f416b8c3e590d274fb1a6
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Astrocytes are essential for the development and homeostatic maintenance of the central nervous system (CNS). They are also critical players in the CNS injury response during which they undergo a process referred to as “reactive astrogliosis.” Di
Externí odkaz:
https://doaj.org/article/3159265feb344db482e6ac1b259efca0
Publikováno v:
Open Biology, Vol 11, Iss 1 (2021)
Myelin sheaths, by supporting axonal integrity and allowing rapid saltatory impulse conduction, are of fundamental importance for neuronal function. In response to demyelinating injuries in the central nervous system (CNS), oligodendrocyte progenitor
Externí odkaz:
https://doaj.org/article/8c189a5b841640e0a64db0229a2d06f2
Autor:
Maria Elena Silva, Simona Lange, Bryan Hinrichsen, Amber R. Philp, Carolina R. Reyes, Diego Halabi, Josselyne B. Mansilla, Peter Rotheneichner, Alerie Guzman de la Fuente, Sebastien Couillard-Despres, Luis F. Bátiz, Robin J. M. Franklin, Ludwig Aigner, Francisco J. Rivera
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Upon demyelination, oligodendrocyte progenitor cells (OPCs) are activated and they proliferate, migrate and differentiate into myelin-producing olig
Externí odkaz:
https://doaj.org/article/a09c50d5bc5048cdb256b80b4b6718c6
Publikováno v:
Annals of the New York Academy of SciencesREFERENCES.
Aging is a major risk factor for several neurodegenerative diseases and is associated with cognitive decline. In addition to affecting neuronal function, the aging process significantly affects the functional phenotype of the glial cell compartment,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2136cbd742ca4dc4a528a610d9f3a5cd
https://pubmed.ncbi.nlm.nih.gov/36398864
https://pubmed.ncbi.nlm.nih.gov/36398864
Autor:
Krystyn J. Van Vliet, Anna Jagielska, Alexis L. Lowe, Ekta Makhija, Liliana Wroblewska, Jochen Guck, Robin J. M. Franklin, G. V. Shivashankar
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Differentiation of oligodendrocyte progenitor cells (OPC) to oligodendrocytes and subsequent axon myelination are critical steps in vertebrate central nervous system (CNS) development and regeneration. Growing evidence supports the significance of me
Externí odkaz:
https://doaj.org/article/ee7455fb847c4337ba68b30762070267
Publikováno v:
Brain : a journal of neurology.
This article reviews recent developments in the application of cell-free DNA-based liquid biopsies to neurological diseases. Over the past few decades, an explosion of interest in the use of accessible biofluids to identify and track molecular diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29c541af99832b65d0caaf1b2aef2a4
https://pubmed.ncbi.nlm.nih.gov/36408894
https://pubmed.ncbi.nlm.nih.gov/36408894