Expanding the Availability of Onasemnogene Abeparvovec to Older Patients: The Evolving Treatment Landscape for Spinal Muscular Atrophy

Autor: Charlotte A. René, Robin J. Parks

Publikováno v: Pharmaceutics, Vol 15, Iss 6, p 1764 (2023)

Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by mutations in the survival of motor neuron 1 (SMN1) gene, which leads to a reduced level in the SMN protein within cells. Patients with SMA suffer from a loss of alpha mot

Externí odkaz: https://doaj.org/article/b8ce72cff56f406696813e1c141d2ace

Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout Infection

Autor: Morgan R. Jennings, Robin J. Parks

Publikováno v: Viruses, Vol 15, Iss 1, p 161 (2023)

Human adenovirus (HAdV) is extremely common and can rapidly spread in confined populations such as daycare centers, hospitals, and retirement homes. Although HAdV usually causes only minor illness in otherwise healthy patients, HAdV can cause signifi

Externí odkaz: https://doaj.org/article/d67363b5409f4b828fe558b64a4bd387

p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling

Autor: Yize Zhang, Chae Young Han, Fu Gang Duan, Xing-Xing Fan, Xiao-Jun Yao, Robin J. Parks, Yi-Jun Tang, Mei-Fang Wang, Liang Liu, Benjamin K. Tsang, Elaine Lai-Han Leung

Publikováno v: Cancer Cell International, Vol 19, Iss 1, Pp 1-13 (2019)

Abstract Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths primarily due to chemoresistance. Somatic mutation of TP53 (36%) and epidermal growth factor receptor (EGFR; > 30%) are major contributors to cisplatin (CDDP

Externí odkaz: https://doaj.org/article/1ea23b3c0e6943e99cd10292b4172a84

Delivery of Therapeutic Agents to the Central Nervous System and the Promise of Extracellular Vesicles

Autor: Charlotte A. René, Robin J. Parks

Publikováno v: Pharmaceutics, Vol 13, Iss 4, p 492 (2021)

The central nervous system (CNS) is surrounded by the blood–brain barrier (BBB), a semipermeable border of endothelial cells that prevents pathogens, solutes and most molecules from non-selectively crossing into the CNS. Thus, the BBB acts to prote

Externí odkaz: https://doaj.org/article/de49e44a07364831b0e7c0f155856667

Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development

Autor: Stephen Boulton, Mathieu J.F. Crupi, Siddharth Singh, Madalina E. Carter-Timofte, Taha Azad, Bailey C. Organ, Xiaohong He, Rida Gill, Serge Neault, Taylor Jamieson, Jaahnavi Dave, Naziia Kurmasheva, Bradley Austin, Julia Petryk, Ragunath Singaravelu, Ben Zhen Huang, Noah Franco, Kaaviya Babu, Robin J. Parks, Carolina S. Ilkow, David Olagnier, John C. Bell

Publikováno v: Boulton, S, Crupi, M J F, Singh, S, Carter-Timofte, M E, Azad, T, Organ, B C, He, X, Gill, R, Neault, S, Jamieson, T, Dave, J, Kurmasheva, N, Austin, B, Petryk, J, Singaravelu, R, Huang, B Z, Franco, N, Babu, K, Parks, R J, Ilkow, C S, Olagnier, D & Bell, J C 2023, ' Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development ', The Journal of Biological Chemistry, vol. 299, no. 6, 104749 . https://doi.org/10.1016/j.jbc.2023.104749

The recent SARS-CoV-2 and mpox outbreaks have highlighted the need to expand our arsenal of broad-spectrum antiviral agents for future pandemic preparedness. Host-directed antivirals are an important tool to accomplish this as they typically offer pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b32745bd6947ccc21790ccd5e16728a
https://pure.au.dk/portal/da/publications/inhibition-of-exchange-proteins-directly-activated-by-camp-as-a-strategy-for-broadspectrum-antiviral-development(6acf2940-262b-421c-9f4c-6c2678322a6a).html