Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Robin H. Edwards"'
Autor:
Daniel F. Hayes, Roy S. Herbst, Jonathan L. Myles, Suzanne L. Topalian, Sophia L. Yohe, Naomi Aronson, Andrew M. Bellizzi, Upal Basu Roy, Georganne Bradshaw, Robin H. Edwards, Ehab A. El-Gabry, Julia Elvin, Thomas F. Gajewski, Lisa M. McShane, Matthew Oberley, Reena Philip, David L. Rimm, Jason N. Rosenbaum, Eric H. Rubin, Lisa Schlager, Shimere W. Sherwood, Mark Stewart, Janis M. Taube, Magdalena Thurin, Patricia Vasalos, Jordan Laser
Publikováno v:
JCO precision oncology. 6
PURPOSE Immune checkpoint inhibition (ICI) therapy represents one of the great advances in the field of oncology, highlighted by the Nobel Prize in 2018. Multiple predictive biomarkers for ICI benefit have been proposed. These include assessment of p
Autor:
Patrick Vitazka, Liying Yan, Khedoudja Nafa, Victor V. Levenson, Margaret L. Gulley, Shuji Ogino, Dan Jones, Antonia R. Sepulveda, Bin Yang, Wade S. Samowitz, Victoria M. Pratt, Robin H. Edwards
Publikováno v:
The Journal of Molecular Diagnostics. 11:266-278
Methylation of CpG islands in gene promoter regions is a major molecular mechanism of gene silencing and underlies both cancer development and progression. In molecular oncology, testing for the CpG methylation of tissue DNA has emerged as a clinical
Autor:
Viswanathan Muthusamy, Robin H. Edwards, Keiran S.M. Smalley, Min Xiao, Alastair J. King, Keith T. Flaherty, Rooha Contractor, Katherine L. Nathanson, Meenhard Herlyn, Marcus Bosenberg, Thiennga K. Nguyen
Publikováno v:
Cancer Research. 68:5743-5752
Although many melanomas harbor either activating mutations in BRAF or NRAS, there remains a substantial, yet little known, group of tumors without either mutation. Here, we used a genomic strategy to define a novel group of melanoma cell lines with c
Autor:
Lianjun Chen, Steven Kazianis, Hong Yu, Meenhard Herlyn, Patricia Brafford, Robin H. Edwards, Geza Acs, Suresh M. Kumar, Xiaowei Xu
Publikováno v:
Cancer Research. 67:3177-3184
Mutations in the BRAF serine/threonine kinase gene are frequently found in cutaneous melanomas. Activation of hypoxia inducible factor-1α (HIF-1α) in response to both hypoxic stress and oncogenic signals has important implications in cancer develop
Autor:
Debra G.B. Leonard, Robin H. Edwards, Hanna Rennert, LA Dodson, Robert B. Wilson, Yonghong Wang, Kathakali Addya
Publikováno v:
Diagnostic Molecular Pathology. 7:85-89
Using genomic DNA from patients with follicular lymphoma, we performed polymerase chain reaction (PCR) amplifications to detect t(14;18) translocations. Unexpectedly large products of approximately 1 kilobase (kb) were detected by gel electrophoresis
Publikováno v:
Diagnostic Molecular Pathology. 6:91-97
Alveolar rhabdomyosarcoma is a pediatric soft-tissue tumor that is often difficult to distinguish from other small round-cell tumors. The PAX3-FKHR and PAX7-FKHR gene fusions that result from chromosomal translocations in this tumor provide potential
Autor:
S Nussen-Lee, Barbara L. Weber, Anne-Marie Martin, Robin H. Edwards, S R Lessin, Meenhard Herlyn, Marcia S. Brose, Michelle Renee Ward, H M Haupt, C A Medina, H Wu, Patricia Volpe
Publikováno v:
Journal of Medical Genetics. 41:270-272
Background: Mutations in BRAF have recently been identified in a significant percentage of primary and metastatic cutaneous malignant melanomas. As ultraviolet (UV) exposure may play a role in the development of cutaneous melanoma lesions with BRAF m
Autor:
Cynthia S. Spittle, M. Renee Ward, Robin H. Edwards, Eric F. Rappaport, Angelica Medina, Phyllis A. Gimotty, Marcia S. Brose, Meenhard Herlyn, Richard Letrero, Katherine L. Nathanson
Publikováno v:
The Journal of molecular diagnostics : JMD. 9(4)
Mutations in the BRAF gene are found in the majority of cutaneous malignant melanomas and subsets of other tumors. These mutations lead to constitutive activation of BRAF with increased downstream ERK (extracellular signal-regulated kinase) signaling
Autor:
Peter C. Nowell, Jennifer Bird, Hanna Rennert, Mariusz A. Wasik, Kevin E. Salhany, Robin H. Edwards, Malek Kamoun, Roberto Rodriguez, Janet Finan, Jonni S. Moore
Publikováno v:
American journal of clinical pathology. 112(6)
Acute promyelocytic leukemia (APL) represents a subtype of acute myeloid leukemia with characteristic morphologic, molecular, and immunophenotypic features. Previous immunophenotypic analyses have shown that leukemic cells in APL typically express th
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 93(11)
The t(2;13) translocation of alveolar rhabdomyosarcoma results in tumor-specific expression of a chimeric transcription factor containing the N-terminal DNA-binding domain of PAX3 and the C-terminal transactivation domain of FKHR. Here we have tested