Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Robin G Bombardi"'
Autor:
Elaine C Chen, Samuel Rubinstein, Cinque Soto, Robin G Bombardi, Samuel B Day, Luke Myers, Alexey Zaytsev, Mahsa Majedi, R Frank Cornell, James E Crowe
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235713 (2020)
Immunoglobulin light chain amyloidosis is the most common form of systemic amyloidosis. AL amyloidosis is caused by a misfolded light chain produced by a clonal population of plasma cells. Disease status currently is defined by measuring the absolute
Externí odkaz:
https://doaj.org/article/1e0d12326e3f4900985b6fa03650e87a
Autor:
Nina G. Bozhanova, Andrew I. Flyak, Benjamin P. Brown, Stormy E. Ruiz, Jordan Salas, Semi Rho, Robin G. Bombardi, Luke Myers, Cinque Soto, Justin R. Bailey, James E. Crowe, Pamela J. Bjorkman, Jens Meiler
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Identifying determinants of broadly neutralizing antibodies against hepatitis C virus (HCV) may guide HCV vaccine design. Here, the authors discover new anti-HCV antibodies using computational screening and analyze the amino acid composition and sequ
Externí odkaz:
https://doaj.org/article/f9573f4cd2774fcb9a4cbb1c42411547
Autor:
Jesse H. Erasmus, Jacob Archer, Jasmine Fuerte-Stone, Amit P. Khandhar, Emily Voigt, Brian Granger, Robin G. Bombardi, Jennifer Govero, Qing Tan, Lorellin A. Durnell, Rhea N. Coler, Michael S. Diamond, James E. Crowe, Jr., Steven G. Reed, Larissa B. Thackray, Robert H. Carnahan, Neal Van Hoeven
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 402-414 (2020)
Monoclonal antibody (mAb) therapeutics are an effective modality for the treatment of infectious, autoimmune, and cancer-related diseases. However, the discovery, development, and manufacturing processes are complex, resource-consuming activities tha
Externí odkaz:
https://doaj.org/article/caf03de341314d739fa7688cad7cbd42
Autor:
Cinque Soto, Robin G. Bombardi, Morgan Kozhevnikov, Robert S. Sinkovits, Elaine C. Chen, Andre Branchizio, Nurgun Kose, Samuel B. Day, Mark Pilkinton, Madhusudan Gujral, Simon Mallal, James E. Crowe, Jr.
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107882- (2020)
Summary: The collection of T cell receptors (TCRs) generated by somatic recombination is large but unknown. We generate large TCR repertoire datasets as a resource to facilitate detailed studies of the role of TCR clonotypes and repertoires in health
Externí odkaz:
https://doaj.org/article/98fd6f3e962f414a88007480882b26d2
Autor:
Michael P. Doyle, Joseph R. Genualdi, Adam L. Bailey, Nurgun Kose, Christopher Gainza, Jessica Rodriguez, Kristen M. Reeder, Christopher A. Nelson, Prashant N. Jethva, Rachel E. Sutton, Robin G. Bombardi, Michael L. Gross, Justin G. Julander, Daved H. Fremont, Michael S. Diamond, James E. Crowe
Publikováno v:
mBio. 13
Yellow fever virus (YFV) causes sporadic outbreaks of infection in South America and sub-Saharan Africa. While live-attenuated yellow fever virus vaccines based on three substrains of 17D are considered some of the most effective vaccines in use, pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95162fdba45320d9e93e5702f8bdc6fc
https://doi.org/10.1128/mbio.00512-22
https://doi.org/10.1128/mbio.00512-22
Autor:
Robin G. Bombardi, James E. Crowe, Jacob Archer, Steven G. Reed, Jennifer Govero, Jasmine Fuerte-Stone, Lorellin A. Durnell, Emily A. Voigt, Larissa B. Thackray, Brian Granger, Neal Van Hoeven, Qing Tan, Robert H. Carnahan, Rhea N. Coler, Jesse H. Erasmus, Amit P. Khandhar, Michael S. Diamond
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 402-414 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 402-414 (2020)
Monoclonal antibody (mAb) therapeutics are an effective modality for the treatment of infectious, autoimmune, and cancer-related diseases. However, the discovery, development, and manufacturing processes are complex, resource-consuming activities tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd75dc66d3efa94399eaa54f9710e852
https://doi.org/10.1016/j.omtm.2020.06.011
https://doi.org/10.1016/j.omtm.2020.06.011
Autor:
Benjamin J. Doranz, Thomas Broge, Larissa B. Thackray, Lorellin A. Durnell, Cinque Soto, Peter Abbink, Edgar Davidson, Jacob Archer, Qing Tan, Steven G. Reed, Jenny Liang, Robert H. Carnahan, Joseph P. Nkolola, Caitlyn Linde, Elise Larson, Stacey Ertel, Jasmine Fuerte-Stone, Todd J. Suscovich, Michael S. Diamond, Robin G. Bombardi, Jesse H. Erasmus, Thomas C. Linnekin, Galit Alter, Rachel S. Nargi, Neal Van Hoeven, Vicky Roy, Matthew J. Gorman, James E. Crowe, Brian Granger, Pavlo Gilchuk, Mallorie E. Fouch, Taylor Jones, Amit P. Khandhar, Dan H. Barouch
Publikováno v:
Nature biomedical engineering
The emergence and re-emergence of highly virulent viral pathogens with the potential to cause a pandemic creates an urgent need for the accelerated discovery of antiviral therapeutics. Antiviral human monoclonal antibodies (mAbs) are promising candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe3f1d9b019d346311da43c15a49382
https://doi.org/10.1038/s41551-020-0594-x
https://doi.org/10.1038/s41551-020-0594-x
Autor:
Pavlo Gilchuk, Iuliia M. Gilchuk, Natalie J. Thornburg, Cinque Soto, Hannah L. Turner, Sheng Li, Robin G. Bombardi, Jinhui Dong, Naveenchandra Suryadevara, James E. Crowe, Elaine C. Chen, Rachel S. Nargi, Jessica A. Finn, Robert H. Carnahan, Sandhya Bangaru, Ryan P. Irving, Jonna B. Westover, Seth J. Zost, Nurgun Kose, Andrew B. Ward, Rachel E. Sutton
Publikováno v:
J Clin Invest
Broadly reactive antibodies targeting the influenza A virus hemagglutinin (HA) head domain are thought to be rare and to require extensive somatic mutations or unusual structural features to achieve breadth against divergent HA subtypes. Here we desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac5d3d7701f588a04bd97406e9849eb
https://europepmc.org/articles/PMC8321569/
https://europepmc.org/articles/PMC8321569/
Autor:
Pavlo Gilchuk, Adrian Guthals, Stefano R. Bonissone, Jared B. Shaw, Philipp A. Ilinykh, Kai Huang, Robin G. Bombardi, Jenny Liang, Ariadna Grinyo, Edgar Davidson, Elaine C. Chen, Bronwyn M. Gunn, Galit Alter, Erica Ollmann Saphire, Benjamin J. Doranz, Alexander Bukreyev, Larry Zeitlin, Natalie Castellana, James E. Crowe
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Three clinically relevant ebolaviruses – Ebola (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) viruses, are responsible for severe disease and occasional deadly outbreaks in Africa. The largest Ebola virus disease (EVD) epidemic to date in 2013-2016 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1a267fa65767ae369eda21aecdc0d7
http://europepmc.org/articles/PMC8322977
http://europepmc.org/articles/PMC8322977
Autor:
James E. Crowe, Alexander M. Sevy, Cinque Soto, Pavlo Gilchuk, Robin G. Bombardi, Nurgun Kose, Robert S. Sinkovits, Jessica A. Finn, Pranathi Matta, Andre Branchizio
Publikováno v:
Nature. 566:398-402
The human genome contains approximately 20 thousand protein-coding genes1, but the size of the collection of antigen receptors of the adaptive immune system that is generated by the recombination of gene segments with non-templated junctional additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96708bbfa27b2d730c62ec80050a98eb
https://doi.org/10.1038/s41586-019-0934-8
https://doi.org/10.1038/s41586-019-0934-8